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Journal Abstract Search

228 related items for PubMed ID: 7565621

  • 1. Substitution at residue 473 confers progesterone 21-hydroxylase activity to cytochrome P450 2C2.
    Ramarao M, Kemper B.
    Mol Pharmacol; 1995 Sep; 48(3):417-24. PubMed ID: 7565621
    [Abstract] [Full Text] [Related]

  • 2. Hydrophobic side chain requirements for lauric acid and progesterone hydroxylation at amino acid 113 in cytochrome P450 2C2, a potential determinant of substrate specificity.
    Straub P, Johnson EF, Kemper B.
    Arch Biochem Biophys; 1993 Nov 01; 306(2):521-7. PubMed ID: 8215458
    [Abstract] [Full Text] [Related]

  • 3. Differential effects of mutations in substrate recognition site 1 of cytochrome P450 2C2 on lauric acid and progesterone hydroxylation.
    Straub P, Lloyd M, Johnson EF, Kemper B.
    Biochemistry; 1994 Jul 05; 33(26):8029-34. PubMed ID: 8025107
    [Abstract] [Full Text] [Related]

  • 4. Identification by in vitro mutagenesis of the interaction of two segments of C2MstC1, a chimera of cytochromes P450 2C2 and P450 2C1.
    Ramarao MK, Straub P, Kemper B.
    J Biol Chem; 1995 Jan 27; 270(4):1873-80. PubMed ID: 7829524
    [Abstract] [Full Text] [Related]

  • 5. Substitutions in the C-terminal portion of the catalytic domain partially reverse assembly defects introduced by mutations in the N-terminal linker sequence of cytochrome P450 2C2.
    Doray B, Chen CD, Kemper B.
    Biochemistry; 1999 Sep 14; 38(37):12180-6. PubMed ID: 10508423
    [Abstract] [Full Text] [Related]

  • 6. Cassette mutagenesis of a potential substrate recognition region of cytochrome P450 2C2.
    Straub P, Lloyd M, Johnson EF, Kemper B.
    J Biol Chem; 1993 Oct 15; 268(29):21997-2003. PubMed ID: 8408056
    [Abstract] [Full Text] [Related]

  • 7. Different structural requirements at specific proline residue positions in the conserved proline-rich region of cytochrome P450 2C2.
    Chen CD, Kemper B.
    J Biol Chem; 1996 Nov 08; 271(45):28607-11. PubMed ID: 8910491
    [Abstract] [Full Text] [Related]

  • 8. A conserved proline-rich sequence between the N-terminal signal-anchor and catalytic domains is required for assembly of functional cytochrome P450 2C2.
    Chen CD, Doray B, Kemper B.
    Arch Biochem Biophys; 1998 Feb 15; 350(2):233-8. PubMed ID: 9473296
    [Abstract] [Full Text] [Related]

  • 9. Efficient assembly of functional cytochrome P450 2C2 requires a spacer sequence between the N-terminal signal anchor and catalytic domains.
    Chen CD, Doray B, Kemper B.
    J Biol Chem; 1997 Sep 05; 272(36):22891-7. PubMed ID: 9278452
    [Abstract] [Full Text] [Related]

  • 10. Importance of successive prolines in the carboxy-terminal region of P450 2C2 and P450 2C14 for the hydroxylase activities.
    Uno T, Imai Y, Nakamura M, Okamoto N, Fukuda T.
    J Biochem; 1993 Sep 05; 114(3):363-9. PubMed ID: 8282727
    [Abstract] [Full Text] [Related]

  • 11. A hypervariable region of P450IIC5 confers progesterone 21-hydroxylase activity to P450IIC1.
    Kronbach T, Kemper B, Johnson EF.
    Biochemistry; 1991 Jun 25; 30(25):6097-102. PubMed ID: 2059619
    [Abstract] [Full Text] [Related]

  • 12. Identification of rabbit cytochromes P450 2C1 and 2C2 as arachidonic acid epoxygenases.
    Laethem RM, Koop DR.
    Mol Pharmacol; 1992 Dec 25; 42(6):958-63. PubMed ID: 1480136
    [Abstract] [Full Text] [Related]

  • 13. Characterization of the progesterone 21-hydroxylase activity of canine cytochrome P450 PBD-2/P450 2B11 through reconstitution, heterologous expression, and site-directed mutagenesis.
    Born SL, John GH, Harlow GR, Halpert JR.
    Drug Metab Dispos; 1995 Jul 25; 23(7):702-7. PubMed ID: 7587957
    [Abstract] [Full Text] [Related]

  • 14. Targeted antipeptide antibodies to cytochrome P450 2C18 based on epitope mapping of an inhibitory monoclonal antibody to P450 2C51.
    Richardson TH, Griffin KJ, Jung F, Raucy JL, Johnson EF.
    Arch Biochem Biophys; 1997 Feb 15; 338(2):157-64. PubMed ID: 9028867
    [Abstract] [Full Text] [Related]

  • 15. Role of residue 480 in substrate specificity of cytochrome P450 2B5 and 2B11.
    Liu J, He YA, Halpert JR.
    Arch Biochem Biophys; 1996 Mar 01; 327(1):167-73. PubMed ID: 8615687
    [Abstract] [Full Text] [Related]

  • 16. Point mutations at threonine-301 modify substrate specificity of rabbit liver microsomal cytochromes P-450 (laurate (omega-1)-hydroxylase and testosterone 16 alpha-hydroxylase).
    Imai Y, Nakamura M.
    Biochem Biophys Res Commun; 1989 Feb 15; 158(3):717-22. PubMed ID: 2493247
    [Abstract] [Full Text] [Related]

  • 17. Modeling and mutagenesis of the active site of human P450c17.
    Lin D, Zhang LH, Chiao E, Miller WL.
    Mol Endocrinol; 1994 Mar 15; 8(3):392-402. PubMed ID: 8015556
    [Abstract] [Full Text] [Related]

  • 18. Further studies on chimeric P450 2C2/2C14 having testosterone 16 beta-hydroxylase activity which is absent in the parental P450s.
    Uno T, Imai Y.
    J Biochem; 1992 Jul 15; 112(1):155-62. PubMed ID: 1429505
    [Abstract] [Full Text] [Related]

  • 19. Deletion of a conserved tetrapeptide, PPGP, in P450 2C2 results in loss of enzymatic activity without a change in its cellular location.
    Szczesna-Skorupa E, Straub P, Kemper B.
    Arch Biochem Biophys; 1993 Jul 15; 304(1):170-5. PubMed ID: 8323283
    [Abstract] [Full Text] [Related]

  • 20. Role of residues 363 and 206 in conversion of cytochrome P450 2B1 from a steroid 16-hydroxylase to a 15 alpha-hydroxylase.
    Luo Z, He YA, Halpert JR.
    Arch Biochem Biophys; 1994 Feb 15; 309(1):52-7. PubMed ID: 8117113
    [Abstract] [Full Text] [Related]

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