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134 related items for PubMed ID: 7582975

  • 21. Design of P1' and P3' residues of trivalent thrombin inhibitors and their crystal structures.
    Slon-Usakiewicz JJ, Sivaraman J, Li Y, Cygler M, Konishi Y.
    Biochemistry; 2000 Mar 07; 39(9):2384-91. PubMed ID: 10694407
    [Abstract] [Full Text] [Related]

  • 22. New tripeptidic thrombin inhibitors. Influence of P2 and P3 residues on activity and selectivity.
    De Nanteuil G, Gloanec P, Lila C, Portevin B, Boudon A, Rupin A, Verbeuren TJ.
    Bioorg Med Chem; 1995 Aug 07; 3(8):1019-24. PubMed ID: 7582976
    [Abstract] [Full Text] [Related]

  • 23. Refined structure of the hirudin-thrombin complex.
    Rydel TJ, Tulinsky A, Bode W, Huber R.
    J Mol Biol; 1991 Sep 20; 221(2):583-601. PubMed ID: 1920434
    [Abstract] [Full Text] [Related]

  • 24. Hirunorms are true hirudin mimetics. The crystal structure of human alpha-thrombin-hirunorm V complex.
    De Simone G, Lombardi A, Galdiero S, Nastri F, Della Morte R, Staiano N, Pedone C, Bolognesi M, Pavone V.
    Protein Sci; 1998 Feb 20; 7(2):243-53. PubMed ID: 9521099
    [Abstract] [Full Text] [Related]

  • 25. The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin.
    Vijayalakshmi J, Padmanabhan KP, Mann KG, Tulinsky A.
    Protein Sci; 1994 Dec 20; 3(12):2254-71. PubMed ID: 7756983
    [Abstract] [Full Text] [Related]

  • 26. Molecular basis for the inhibition of human alpha-thrombin by the macrocyclic peptide cyclotheonamide A.
    Maryanoff BE, Qiu X, Padmanabhan KP, Tulinsky A, Almond HR, Andrade-Gordon P, Greco MN, Kauffman JA, Nicolaou KC, Liu A.
    Proc Natl Acad Sci U S A; 1993 Sep 01; 90(17):8048-52. PubMed ID: 8367461
    [Abstract] [Full Text] [Related]

  • 27. Crystal structure of human alpha-thrombin complexed with hirugen and p-amidinophenylpyruvate at 1.6 A resolution.
    Chen Z, Li Y, Mulichak AM, Lewis SD, Shafer JA.
    Arch Biochem Biophys; 1995 Sep 10; 322(1):198-203. PubMed ID: 7574675
    [Abstract] [Full Text] [Related]

  • 28. The methyl group of N(alpha)(Me)Arg-containing peptides disturbs the active-site geometry of thrombin, impairing efficient cleavage.
    Friedrich R, Steinmetzer T, Huber R, Stürzebecher J, Bode W.
    J Mol Biol; 2002 Mar 01; 316(4):869-74. PubMed ID: 11884127
    [Abstract] [Full Text] [Related]

  • 29. Structures of thrombin retro-inhibited with SEL2711 and SEL2770 as they relate to factor Xa binding.
    Mochalkin I, Tulinsky A.
    Acta Crystallogr D Biol Crystallogr; 1999 Apr 01; 55(Pt 4):785-93. PubMed ID: 10089309
    [Abstract] [Full Text] [Related]

  • 30. Cyclotheonamide derivatives: synthesis and thrombin inhibition. Exploration of specific structure-function issues.
    Maryanoff BE, Zhang HC, Greco MN, Glover KA, Kauffman JA, Andrade-Gordon P.
    Bioorg Med Chem; 1995 Aug 01; 3(8):1025-38. PubMed ID: 7582977
    [Abstract] [Full Text] [Related]

  • 31. Biochemical and crystallographic characterization of homologous non-peptidic thrombin inhibitors having alternate binding modes.
    Strickland CL, Fevig JM, Galemmo RA, Wells BL, Kettner CA, Weber PC.
    Acta Crystallogr D Biol Crystallogr; 1998 Nov 01; 54(Pt 6 Pt 2):1207-15. PubMed ID: 10089499
    [Abstract] [Full Text] [Related]

  • 32. Hydroxyethylene isostere inhibitors of human immunodeficiency virus-1 protease: structure-activity analysis using enzyme kinetics, X-ray crystallography, and infected T-cell assays.
    Dreyer GB, Lambert DM, Meek TD, Carr TJ, Tomaszek TA, Fernandez AV, Bartus H, Cacciavillani E, Hassell AM, Minnich M.
    Biochemistry; 1992 Jul 28; 31(29):6646-59. PubMed ID: 1637805
    [Abstract] [Full Text] [Related]

  • 33. Kinetic and crystallographic studies of thrombin with Ac-(D)Phe-Pro-boroArg-OH and its lysine, amidine, homolysine, and ornithine analogs.
    Weber PC, Lee SL, Lewandowski FA, Schadt MC, Chang CW, Kettner CA.
    Biochemistry; 1995 Mar 21; 34(11):3750-7. PubMed ID: 7893672
    [Abstract] [Full Text] [Related]

  • 34. Molecular modeling studies of novel retro-binding tripeptide active-site inhibitors of thrombin.
    Lau WF, Tabernero L, Sack JS, Iwanowicz EJ.
    Bioorg Med Chem; 1995 Aug 21; 3(8):1039-48. PubMed ID: 7582978
    [Abstract] [Full Text] [Related]

  • 35. Rational design and characterization of D-Phe-Pro-D-Arg-derived direct thrombin inhibitors.
    Figueiredo AC, Clement CC, Zakia S, Gingold J, Philipp M, Pereira PJ.
    PLoS One; 2012 Aug 21; 7(3):e34354. PubMed ID: 22457833
    [Abstract] [Full Text] [Related]

  • 36. Active site-directed thrombin inhibitors: alpha-hydroxyacyl-prolyl-arginals. New orally active stable analogs of D-Phe-Pro-Arg-H.
    Bajusz S, Barabás E, Fauszt I, Fehér A, Horváth G, Juhász A, Szabó AG, Széll E.
    Bioorg Med Chem; 1995 Aug 21; 3(8):1079-89. PubMed ID: 7582981
    [Abstract] [Full Text] [Related]

  • 37. Design of potent bivalent thrombin inhibitors based on hirudin sequence: incorporation of nonsubstrate-type active site inhibitors.
    Tsuda Y, Cygler M, Gibbs BF, Pedyczak A, Féthière J, Yue SY, Konishi Y.
    Biochemistry; 1994 Dec 06; 33(48):14443-51. PubMed ID: 7981204
    [Abstract] [Full Text] [Related]

  • 38. Structural analysis of thrombin complexed with potent inhibitors incorporating a phenyl group as a peptide mimetic and aminopyridines as guanidine substitutes.
    Bone R, Lu T, Illig CR, Soll RM, Spurlino JC.
    J Med Chem; 1998 Jun 04; 41(12):2068-75. PubMed ID: 9622548
    [Abstract] [Full Text] [Related]

  • 39. The crystal structures of human alpha-thrombin complexed with active site-directed diamino benzo[b]thiophene derivatives: a binding mode for a structurally novel class of inhibitors.
    Chirgadze NY, Sall DJ, Briggs SL, Clawson DK, Zhang M, Smith GF, Schevitz RW.
    Protein Sci; 2000 Jan 04; 9(1):29-36. PubMed ID: 10739244
    [Abstract] [Full Text] [Related]

  • 40. The crystal structure of human alpha-thrombin complexed with LY178550, a nonpeptidyl, active site-directed inhibitor.
    Chirgadze NY, Sall DJ, Klimkowski VJ, Clawson DK, Briggs SL, Hermann R, Smith GF, Gifford-Moore DS, Wery JP.
    Protein Sci; 1997 Jul 04; 6(7):1412-7. PubMed ID: 9232642
    [Abstract] [Full Text] [Related]

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