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463 related items for PubMed ID: 7585636

  • 1. Activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human lung microsomes by cytochromes P450, lipoxygenase, and hydroperoxides.
    Smith TJ, Stoner GD, Yang CS.
    Cancer Res; 1995 Dec 01; 55(23):5566-73. PubMed ID: 7585636
    [Abstract] [Full Text] [Related]

  • 2. Enzymes involved in the bioactivation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in patas monkey lung and liver microsomes.
    Smith TJ, Liao AM, Liu Y, Jones AB, Anderson LM, Yang CS.
    Carcinogenesis; 1997 Aug 01; 18(8):1577-84. PubMed ID: 9276633
    [Abstract] [Full Text] [Related]

  • 3. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human lung and liver microsomes and cytochromes P-450 expressed in hepatoma cells.
    Smith TJ, Guo Z, Gonzalez FJ, Guengerich FP, Stoner GD, Yang CS.
    Cancer Res; 1992 Apr 01; 52(7):1757-63. PubMed ID: 1312898
    [Abstract] [Full Text] [Related]

  • 4. Kinetic analysis of the activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by heterologously expressed human P450 enzymes and the effect of P450-specific chemical inhibitors on this activation in human liver microsomes.
    Patten CJ, Smith TJ, Murphy SE, Wang MH, Lee J, Tynes RE, Koch P, Yang CS.
    Arch Biochem Biophys; 1996 Sep 01; 333(1):127-38. PubMed ID: 8806763
    [Abstract] [Full Text] [Related]

  • 5. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by human cytochrome P450 1A2 and its inhibition by phenethyl isothiocyanate.
    Smith TJ, Guo Z, Guengerich FP, Yang CS.
    Carcinogenesis; 1996 Apr 01; 17(4):809-13. PubMed ID: 8625495
    [Abstract] [Full Text] [Related]

  • 6. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mouse lung microsomes and its inhibition by isothiocyanates.
    Smith TJ, Guo ZY, Thomas PE, Chung FL, Morse MA, Elkind K, Yang CS.
    Cancer Res; 1990 Nov 01; 50(21):6817-22. PubMed ID: 2208146
    [Abstract] [Full Text] [Related]

  • 7. Mechanisms of inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone bioactivation in mouse by dietary phenethyl isothiocyanate.
    Smith TJ, Guo Z, Li C, Ning SM, Thomas PE, Yang CS.
    Cancer Res; 1993 Jul 15; 53(14):3276-82. PubMed ID: 8324738
    [Abstract] [Full Text] [Related]

  • 8. Kinetics and enzyme involvement in the metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in microsomes of rat lung and nasal mucosa.
    Smith TJ, Guo Z, Hong JY, Ning SM, Thomas PE, Yang CS.
    Carcinogenesis; 1992 Aug 15; 13(8):1409-14. PubMed ID: 1499091
    [Abstract] [Full Text] [Related]

  • 9. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by inducible and constitutive cytochrome P450 enzymes in rats.
    Guo Z, Smith TJ, Thomas PE, Yang CS.
    Arch Biochem Biophys; 1992 Oct 15; 298(1):279-86. PubMed ID: 1524438
    [Abstract] [Full Text] [Related]

  • 10. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by cytochrome P450IIB1 in a reconstituted system.
    Guo Z, Smith TJ, Ishizaki H, Yang CS.
    Carcinogenesis; 1991 Dec 15; 12(12):2277-82. PubMed ID: 1747927
    [Abstract] [Full Text] [Related]

  • 11. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human placental microsomes.
    Collazo NR, Sultatos LG.
    Biochem Pharmacol; 1995 Nov 27; 50(11):1933-41. PubMed ID: 8615875
    [Abstract] [Full Text] [Related]

  • 12. Biotransformation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in peripheral human lung microsomes.
    Smith GB, Bend JR, Bedard LL, Reid KR, Petsikas D, Massey TE.
    Drug Metab Dispos; 2003 Sep 27; 31(9):1134-41. PubMed ID: 12920169
    [Abstract] [Full Text] [Related]

  • 13. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific carcinogen, by rabbit nasal microsomes and cytochrome P450s NMa and NMb.
    Hong JY, Ding X, Smith TJ, Coon MJ, Yang CS.
    Carcinogenesis; 1992 Nov 27; 13(11):2141-4. PubMed ID: 1423886
    [Abstract] [Full Text] [Related]

  • 14. 11Beta-hydroxysteroid dehydrogenase responsible for carbonyl reduction of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mouse lung microsomes.
    Maser E.
    Cancer Res; 1998 Jul 15; 58(14):2996-3003. PubMed ID: 9679962
    [Abstract] [Full Text] [Related]

  • 15. Biotransformation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in lung tissue from mouse, rat, hamster, and man.
    Richter E, Engl J, Friesenegger S, Tricker AR.
    Chem Res Toxicol; 2009 Jun 15; 22(6):1008-17. PubMed ID: 19408892
    [Abstract] [Full Text] [Related]

  • 16. Investigation of the role of lipoxygenase in bioactivation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human lung.
    Bedard LL, Smith GB, Reid KR, Petsikas D, Massey TE.
    Chem Res Toxicol; 2002 Oct 15; 15(10):1267-73. PubMed ID: 12387624
    [Abstract] [Full Text] [Related]

  • 17. Evidence for cytochrome P450 2A6 and 3A4 as major catalysts for N'-nitrosonornicotine alpha-hydroxylation by human liver microsomes.
    Patten CJ, Smith TJ, Friesen MJ, Tynes RE, Yang CS, Murphy SE.
    Carcinogenesis; 1997 Aug 15; 18(8):1623-30. PubMed ID: 9276639
    [Abstract] [Full Text] [Related]

  • 18. Comparative metabolism of the tobacco-related carcinogens benzo[a]pyrene, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, and N'- nitrosonornicotine in human hepatic microsomes.
    Staretz ME, Murphy SE, Patten CJ, Nunes MG, Koehl W, Amin S, Koenig LA, Guengerich FP, Hecht SS.
    Drug Metab Dispos; 1997 Feb 15; 25(2):154-62. PubMed ID: 9029045
    [Abstract] [Full Text] [Related]

  • 19. Human cervical tissue metabolizes the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, via alpha-hydroxylation and carbonyl reduction pathways.
    Prokopczyk B, Trushin N, Leszczynska J, Waggoner SE, El-Bayoumy K.
    Carcinogenesis; 2001 Jan 15; 22(1):107-14. PubMed ID: 11159748
    [Abstract] [Full Text] [Related]

  • 20. Metabolic activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone as measured by DNA alkylation in vitro and its inhibition by isothiocyanates.
    Guo Z, Smith TJ, Thomas PE, Yang CS.
    Cancer Res; 1991 Sep 15; 51(18):4798-803. PubMed ID: 1893372
    [Abstract] [Full Text] [Related]

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