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Journal Abstract Search


139 related items for PubMed ID: 7586076

  • 1. Synthesis and structure-activity studies of a series of 1-oxa-2,8-diazaspiro[4.5]decan-3-ones and related compounds as M1 muscarinic agonists.
    Tsukamoto S, Nagaoka H, Igarashi S, Wanibuchi F, Hidaka K, Tamura T.
    Chem Pharm Bull (Tokyo); 1995 Sep; 43(9):1523-9. PubMed ID: 7586076
    [Abstract] [Full Text] [Related]

  • 2. Synthesis and structure-activity studies of a series of 1-oxa-8-azaspiro[4.5]decanes as M1 muscarinic agonists.
    Tsukamoto S, Fujii M, Yasunaga T, Matsuda K, Wanibuchi F, Hidaka K, Furuya T, Tamura T.
    Chem Pharm Bull (Tokyo); 1995 May; 43(5):842-52. PubMed ID: 7553970
    [Abstract] [Full Text] [Related]

  • 3. Pharmacological studies on novel muscarinic agonists, 1-oxa-8-azaspiro[4.5]decane derivatives, YM796 and YM954.
    Wanibuchi F, Konishi T, Harada M, Terai M, Hidaka K, Tamura T, Tsukamoto S, Usuda S.
    Eur J Pharmacol; 1990 Oct 23; 187(3):479-86. PubMed ID: 1963596
    [Abstract] [Full Text] [Related]

  • 4. Characterization of a novel muscarinic receptor agonist, YM796: comparison with cholinesterase inhibitors in in vivo pharmacological studies.
    Wanibuchi F, Nishida T, Yamashita H, Hidaka K, Koshiya K, Tsukamoto S, Usuda S.
    Eur J Pharmacol; 1994 Nov 24; 265(3):151-8. PubMed ID: 7875230
    [Abstract] [Full Text] [Related]

  • 5. Synthesis and structure-activity studies of a series of spirooxazolidine-2,4-diones: 4-oxa analogues of the muscarinic agonist 2-ethyl-8-methyl-2,8-diazaspiro[4.5]decane-1,3-dione.
    Tsukamoto S, Ichihara M, Wanibuchi F, Usuda S, Hidaka K, Harada M, Tamura T.
    J Med Chem; 1993 Aug 06; 36(16):2292-9. PubMed ID: 8360873
    [Abstract] [Full Text] [Related]

  • 6. Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity.
    Bymaster FP, Carter PA, Yamada M, Gomeza J, Wess J, Hamilton SE, Nathanson NM, McKinzie DL, Felder CC.
    Eur J Neurosci; 2003 Apr 06; 17(7):1403-10. PubMed ID: 12713643
    [Abstract] [Full Text] [Related]

  • 7. Down-regulation and desensitization of the muscarinic M1 and M2 receptors in transfected fibroblast B82 cells.
    Wei HB, Yamamura HI, Roeske WR.
    Eur J Pharmacol; 1994 Aug 16; 268(3):381-91. PubMed ID: 7805762
    [Abstract] [Full Text] [Related]

  • 8. The pharmacological assessment of RS 86 (2-ethyl-8-methyl-2,8-diazaspiro-[4,5]-decan-1,3-dion hydrobromide). A potent, specific muscarinic acetylcholine receptor agonist.
    Palacios JM, Bolliger G, Closse A, Enz A, Gmelin G, Malanowski J.
    Eur J Pharmacol; 1986 Jun 05; 125(1):45-62. PubMed ID: 3732391
    [Abstract] [Full Text] [Related]

  • 9. 2-(Substituted)amino-2,8-diazaspiro[4,5]decan-1,3-diones as potential muscarinic agonists: synthesis, modeling and binding studies.
    Barlocco D, Fanelli F, Cignarella G, Villa S, Cattabeni F, Balduini W, Cimino M, De Benedetti PG.
    Drug Des Discov; 1996 Oct 05; 14(2):129-43. PubMed ID: 9010619
    [Abstract] [Full Text] [Related]

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  • 11. Activation of cerebral function by CS-932, a functionally selective M1 partial agonist: neurochemical characterization and pharmacological studies.
    Iwata N, Kozuka M, Hara T, Kanek T, Tonohiro T, Sugimoto M, Niitsu Y, Kondo Y, Yamamoto T, Sakai J, Nagano M.
    Jpn J Pharmacol; 2000 Nov 05; 84(3):266-80. PubMed ID: 11138727
    [Abstract] [Full Text] [Related]

  • 12. Central cholinergic agents. III. Synthesis of 2-alkoxy-2,8- diazaspiro[4.5]decane-1,3-diones as muscarinic agonists.
    Ishihara Y, Yukimasa H, Miyamoto M, Goto G.
    Chem Pharm Bull (Tokyo); 1992 May 05; 40(5):1177-85. PubMed ID: 1394631
    [Abstract] [Full Text] [Related]

  • 13. Novel alkoxy-oxazolyl-tetrahydropyridine muscarinic cholinergic receptor antagonists.
    Shannon HE, Bymaster FP, Hendrix JC, Quimby SJ, Mitch CH.
    Psychopharmacology (Berl); 1995 Jan 05; 117(2):208-15. PubMed ID: 7753969
    [Abstract] [Full Text] [Related]

  • 14. Effects of (-)-S-2,8-dimethyl-3-methylene-1-oxa-8-azaspiro[4,5]decane L-tartrate monohydrate (YM796), a novel muscarinic agonist, on disturbance of passive avoidance learning behavior in drug-treated and senescence-accelerated mice.
    Suzuki M, Yamaguchi T, Ozawa Y, Ohyama M, Yamamoto M.
    J Pharmacol Exp Ther; 1995 Nov 05; 275(2):728-36. PubMed ID: 7473160
    [Abstract] [Full Text] [Related]

  • 15. Synthesis and muscarinic activity of a series of quinolines and naphthalenes with a 1-azabicyclo[3.3.0]octane moiety.
    Suzuki T, Usui T, Oka M, Suzuki T, Kataoka T.
    Chem Pharm Bull (Tokyo); 1998 Aug 05; 46(8):1265-73. PubMed ID: 9734314
    [Abstract] [Full Text] [Related]

  • 16. Biochemical and behavioral characterization of a novel cholinergic agonist, SR 95639.
    Boast CA, Leventer S, Sabb A, Abelson M, Bender R, Giacomo D, Maurer S, McArthur S, Mehta O, Morris H.
    Pharmacol Biochem Behav; 1991 Jun 05; 39(2):287-92. PubMed ID: 1658814
    [Abstract] [Full Text] [Related]

  • 17. Synthesis and biological characterization of 1,4,5,6-tetrahydropyrimidine and 2-amino-3,4,5,6-tetrahydropyridine derivatives as selective m1 agonists.
    Messer WS, Abuh YF, Liu Y, Periyasamy S, Ngur DO, Edgar MA, El-Assadi AA, Sbeih S, Dunbar PG, Roknich S, Rho T, Fang Z, Ojo B, Zhang H, Huzl JJ, Nagy PI.
    J Med Chem; 1997 Apr 11; 40(8):1230-46. PubMed ID: 9111297
    [Abstract] [Full Text] [Related]

  • 18. 1-(1,2,5-Thiadiazol-4-yl)-4-azatricyclo[2.2.1.0(2,6)]heptanes as new potent muscarinic M1 agonists: structure-activity relationship for 3-aryl-2-propyn-1-yloxy and 3-aryl-2-propyn-1-ylthio derivatives.
    Jeppesen L, Olesen PH, Hansen L, Sheardown MJ, Thomsen C, Rasmussen T, Jensen AF, Christensen MS, Rimvall K, Ward JS, Whitesitt C, Calligaro DO, Bymaster FP, Delapp NW, Felder CC, Shannon HE, Sauerberg P.
    J Med Chem; 1999 Jun 03; 42(11):1999-2006. PubMed ID: 10354408
    [Abstract] [Full Text] [Related]

  • 19. Alterations in behavioral responses to a cholinergic agonist in post-pubertal rats with neonatal ventral hippocampal lesions: relationship to changes in muscarinic receptor levels.
    Laplante F, Nakagawasai O, Srivastava LK, Quirion R.
    Neuropsychopharmacology; 2005 Jun 03; 30(6):1076-87. PubMed ID: 15637638
    [Abstract] [Full Text] [Related]

  • 20. Pharmacological characterization of a novel muscarinic partial agonist, YM796, in transfected cells expressing the m1 or m2 muscarinic receptor gene.
    Wei HB, Roeske WR, Lai J, Wanibuchi F, Hidaka K, Usuda S, Yamamura HI.
    Life Sci; 1992 Jun 03; 50(5):355-63. PubMed ID: 1310135
    [Abstract] [Full Text] [Related]


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