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144 related items for PubMed ID: 7592937

  • 1. Different antifolate-resistant L1210 cell variants with either increased or decreased folylpolyglutamate synthetase gene expression at the level of mRNA transcription.
    Roy K, Mitsugi K, Sirlin S, Shane B, Sirotnak FM.
    J Biol Chem; 1995 Nov 10; 270(45):26918-22. PubMed ID: 7592937
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  • 2. Posttranscriptionally mediated decreases in folylpolyglutamate synthetase gene expression in some folate analogue-resistant variants of the L1210 cell. Evidence for an altered cognate mRNA in the variants affecting the rate of de novo synthesis of the enzyme.
    Roy K, Egan MG, Sirlin S, Sirotnak FM.
    J Biol Chem; 1997 Mar 14; 272(11):6903-8. PubMed ID: 9054377
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  • 3. Chromosomal localization of the murine RFC-1 gene encoding a folate transporter and its amplification in an antifolate resistant variant overproducing the transporter.
    Roy K, Chiao JH, Spengler BA, Tolner B, Yang CH, Biedler JL, Sirotnak FM.
    Cancer Genet Cytogenet; 1998 Aug 14; 105(1):29-38. PubMed ID: 9689927
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  • 4. Rapid decline in folylpolyglutamate synthetase activity and gene expression during maturation of HL-60 cells. Nature of the effect, impact on folate compound polyglutamate pools, and evidence for programmed down-regulation during maturation.
    Egan MG, Sirlin S, Rumberger BG, Garrow TA, Shane B, Sirotnak FM.
    J Biol Chem; 1995 Mar 10; 270(10):5462-8. PubMed ID: 7890662
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  • 10. Decreased expression of the reduced folate carrier and folypolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line.
    Wang Y, Zhao R, Goldman ID.
    Biochem Pharmacol; 2003 Apr 01; 65(7):1163-70. PubMed ID: 12663051
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  • 14. Folylpoly-gamma-glutamate synthetase: generation of isozymes and the role in one carbon metabolism and antifolate cytotoxicity.
    Qi H, Atkinson I, Xiao S, Choi YJ, Tobimatsu T, Shane B.
    Adv Enzyme Regul; 1999 Apr 01; 39():263-73. PubMed ID: 10470377
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  • 15. Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity.
    Westerhof GR, Schornagel JH, Kathmann I, Jackman AL, Rosowsky A, Forsch RA, Hynes JB, Boyle FT, Peters GJ, Pinedo HM.
    Mol Pharmacol; 1995 Sep 01; 48(3):459-71. PubMed ID: 7565626
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  • 16. Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia.
    Stark M, Wichman C, Avivi I, Assaraf YG.
    Blood; 2009 Apr 30; 113(18):4362-9. PubMed ID: 19131550
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  • 17. Organization and alternate splicing of the murine folylpolyglutamate synthetase gene. Different splice variants in L1210 cells encode mitochondrial or cytosolic forms of the enzyme.
    Roy K, Mitsugi K, Sirotnak FM.
    J Biol Chem; 1996 Sep 27; 271(39):23820-7. PubMed ID: 8798611
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  • 18. Differing specificities for 4-aminofolate analogues of folylpolyglutamyl synthetase from tumors and proliferative intestinal epithelium of the mouse with significance for selective antitumor action.
    Rumberger BG, Barrueco JR, Sirotnak FM.
    Cancer Res; 1990 Aug 01; 50(15):4639-43. PubMed ID: 2369741
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  • 20. Design and synthesis of histidine analogues of folic acid and methotrexate as potential folylpolyglutamate synthetase inhibitors.
    Mao Z, Pan J, Kalman TI.
    J Med Chem; 1996 Oct 11; 39(21):4340-4. PubMed ID: 8863812
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