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85 related items for PubMed ID: 7605348

  • 1. Efficient redox cycling of nitroquinoline bioreductive drugs due to aerobic nitroreduction in Chinese hamster cells.
    Siim BG, Wilson WR.
    Biochem Pharmacol; 1995 Jun 29; 50(1):75-82. PubMed ID: 7605348
    [Abstract] [Full Text] [Related]

  • 2. Metabolic and radiolytic reduction of 4-alkylamino-5-nitroquinoline bioreductive drugs. Relationship to hypoxia-selective cytotoxicity.
    Siim BG, Atwell GJ, Wilson WR.
    Biochem Pharmacol; 1994 Oct 18; 48(8):1593-604. PubMed ID: 7980625
    [Abstract] [Full Text] [Related]

  • 3. Oxygen dependence of the cytotoxicity and metabolic activation of 4-alkylamino-5-nitroquinoline bioreductive drugs.
    Siim BG, Atwell GJ, Wilson WR.
    Br J Cancer; 1994 Oct 18; 70(4):596-603. PubMed ID: 7917903
    [Abstract] [Full Text] [Related]

  • 4. Hypoxia-selective antitumor agents. 15. Modification of rate of nitroreduction and extent of lysosomal uptake by polysubstitution of 4-(alkylamino)-5-nitroquinoline bioreductive drugs.
    Siim BG, Atwell GJ, Anderson RF, Wardman P, Pullen SM, Wilson WR, Denny WA.
    J Med Chem; 1997 Apr 25; 40(9):1381-90. PubMed ID: 9135035
    [Abstract] [Full Text] [Related]

  • 5. Does DNA targeting affect the cytotoxicity and cell uptake of basic nitroquinoline bioreductive drugs?
    Siim BG, Denny WA, Wilson WR.
    Int J Radiat Oncol Biol Phys; 1994 May 15; 29(2):311-5. PubMed ID: 8195025
    [Abstract] [Full Text] [Related]

  • 6. The effect of functional groups on reduction and activation of quinone bioreductive agents by DT-diaphorase.
    Fourie J, Oleschuk CJ, Guziec F, Guziec L, Fiterman DJ, Monterrosa C, Begleiter A.
    Cancer Chemother Pharmacol; 2002 Feb 15; 49(2):101-10. PubMed ID: 11862423
    [Abstract] [Full Text] [Related]

  • 7. Interactions of the carcinogen 4-nitroquinoline 1-oxide with the non-protein thiols of mammalian cells.
    Varnes ME, Biaglow JE.
    Cancer Res; 1979 Aug 15; 39(8):2960-5. PubMed ID: 110443
    [Abstract] [Full Text] [Related]

  • 8. Penetration of AF-2 and 4NQO into multicell spheroids.
    Olive PL, Durand RE.
    Environ Mutagen; 1983 Aug 15; 5(4):553-63. PubMed ID: 6409603
    [Abstract] [Full Text] [Related]

  • 9. The two faces of aldehyde oxidase: Oxidative and reductive transformations of 5-nitroquinoline.
    Paragas EM, Humphreys SC, Min J, Joswig-Jones CA, Jones JP.
    Biochem Pharmacol; 2017 Dec 01; 145():210-217. PubMed ID: 28888950
    [Abstract] [Full Text] [Related]

  • 10. Metabolic reduction of 4-nitroquinoline N-oxide and other radical-producing drugs to oxygen-reactive intermediates.
    Biaglow JE, Jacobson BE, Nygaard OF.
    Cancer Res; 1977 Sep 01; 37(9):3306-13. PubMed ID: 406989
    [No Abstract] [Full Text] [Related]

  • 11. Toxicity of nitrobenzene compounds towards isolated hepatocytes: dependence on reduction potential.
    O'Brien PJ, Wong WC, Silva J, Khan S.
    Xenobiotica; 1990 Sep 01; 20(9):945-55. PubMed ID: 2238713
    [Abstract] [Full Text] [Related]

  • 12. Caffeine inhibition of the metabolic activation of a carcinogen, 4-nitroquinoline-1-oxide, in cultured Chinese hamster cells.
    Tsuda H, Yoshida D, Mizusaki S.
    Carcinogenesis; 1984 Mar 01; 5(3):331-4. PubMed ID: 6200248
    [Abstract] [Full Text] [Related]

  • 13. N-[2-(2-methyl-5-nitroimidazolyl)ethyl]-4-(2-nitroimidazolyl)butanamide (NSC 639862), a bisnitroimidazole with enhanced selectivity as a bioreductive drug.
    Moselen JW, Hay MP, Denny WA, Wilson WR.
    Cancer Res; 1995 Feb 01; 55(3):574-80. PubMed ID: 7834627
    [Abstract] [Full Text] [Related]

  • 14. Hypoxia-selective antitumor agents. 13. Effects of acridine substitution on the hypoxia-selective cytotoxicity and metabolic reduction of the bis-bioreductive agent nitracrine N-oxide.
    Lee HH, Wilson WR, Ferry DM, van Zijl P, Pullen SM, Denny WA.
    J Med Chem; 1996 Jun 21; 39(13):2508-17. PubMed ID: 8691448
    [Abstract] [Full Text] [Related]

  • 15. Effect of nitroreduction on the alkylating reactivity and cytotoxicity of the 2,4-dinitrobenzamide-5-aziridine CB 1954 and the corresponding nitrogen mustard SN 23862: distinct mechanisms of bioreductive activation.
    Helsby NA, Wheeler SJ, Pruijn FB, Palmer BD, Yang S, Denny WA, Wilson WR.
    Chem Res Toxicol; 2003 Apr 21; 16(4):469-78. PubMed ID: 12703963
    [Abstract] [Full Text] [Related]

  • 16. Role of metabolism and oxidation-reduction cycling in the cytotoxicity of antitumor quinoneimines and quinonediimines.
    Powis G, Hodnett EM, Santone KS, See KL, Melder DC.
    Cancer Res; 1987 May 01; 47(9):2363-70. PubMed ID: 3032421
    [Abstract] [Full Text] [Related]

  • 17. Redox cycling of radical anion metabolites of toxic chemicals and drugs and the Marcus theory of electron transfer.
    Mason RP.
    Environ Health Perspect; 1990 Jul 01; 87():237-43. PubMed ID: 2176587
    [Abstract] [Full Text] [Related]

  • 18. S9-mediated metabolism of 1-nitropyrene to a mutagen in Chinese hamster ovary cells by ring-oxidation under aerobic conditions and by nitroreduction under anaerobic conditions.
    Thornton-Manning JR, Smith BA, Beland FA, Heflich RH.
    Carcinogenesis; 1991 Dec 01; 12(12):2317-23. PubMed ID: 1747934
    [Abstract] [Full Text] [Related]

  • 19. In cellulo monitoring of quinone reductase activity and reactive oxygen species production during the redox cycling of 1,2 and 1,4 quinones.
    Cassagnes LE, Perio P, Ferry G, Moulharat N, Antoine M, Gayon R, Boutin JA, Nepveu F, Reybier K.
    Free Radic Biol Med; 2015 Dec 01; 89():126-34. PubMed ID: 26386287
    [Abstract] [Full Text] [Related]

  • 20. Enzymatic conversion of 6-nitroquinoline to the fluorophore 6-aminoquinoline selectively under hypoxic conditions.
    Rajapakse A, Linder C, Morrison RD, Sarkar U, Leigh ND, Barnes CL, Daniels JS, Gates KS.
    Chem Res Toxicol; 2013 Apr 15; 26(4):555-63. PubMed ID: 23488987
    [Abstract] [Full Text] [Related]

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