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Journal Abstract Search

180 related items for PubMed ID: 7621814

  • 1. The unique extracellular disulfide loop of the glycine receptor is a principal ligand binding element.
    Rajendra S, Vandenberg RJ, Pierce KD, Cunningham AM, French PW, Barry PH, Schofield PR.
    EMBO J; 1995 Jul 03; 14(13):2987-98. PubMed ID: 7621814
    [Abstract] [Full Text] [Related]

  • 2. The extracellular disulfide loop motif of the inhibitory glycine receptor does not form the agonist binding site.
    Vandenberg RJ, Rajendra S, French CR, Barry PH, Schofield PR.
    Mol Pharmacol; 1993 Jul 03; 44(1):198-203. PubMed ID: 8393521
    [Abstract] [Full Text] [Related]

  • 3. Mapping of disulfide bonds within the amino-terminal extracellular domain of the inhibitory glycine receptor.
    Vogel N, Kluck CJ, Melzer N, Schwarzinger S, Breitinger U, Seeber S, Becker CM.
    J Biol Chem; 2009 Dec 25; 284(52):36128-36136. PubMed ID: 19861413
    [Abstract] [Full Text] [Related]

  • 4. Distinct agonist- and antagonist-binding sites on the glycine receptor.
    Vandenberg RJ, Handford CA, Schofield PR.
    Neuron; 1992 Sep 25; 9(3):491-6. PubMed ID: 1326295
    [Abstract] [Full Text] [Related]

  • 5. Alanine-scanning mutagenesis in the signature disulfide loop of the glycine receptor alpha 1 subunit: critical residues for activation and modulation.
    Schofield CM, Trudell JR, Harrison NL.
    Biochemistry; 2004 Aug 10; 43(31):10058-63. PubMed ID: 15287733
    [Abstract] [Full Text] [Related]

  • 6. Antagonism of ligand-gated ion channel receptors: two domains of the glycine receptor alpha subunit form the strychnine-binding site.
    Vandenberg RJ, French CR, Barry PH, Shine J, Schofield PR.
    Proc Natl Acad Sci U S A; 1992 Mar 01; 89(5):1765-9. PubMed ID: 1311851
    [Abstract] [Full Text] [Related]

  • 7. The Startle Disease Mutation E103K Impairs Activation of Human Homomeric α1 Glycine Receptors by Disrupting an Intersubunit Salt Bridge across the Agonist Binding Site.
    Safar F, Hurdiss E, Erotocritou M, Greiner T, Lape R, Irvine MW, Fang G, Jane D, Yu R, Dämgen MA, Biggin PC, Sivilotti LG.
    J Biol Chem; 2017 Mar 24; 292(12):5031-5042. PubMed ID: 28174298
    [Abstract] [Full Text] [Related]

  • 8. A highly conserved aspartic acid residue in the signature disulfide loop of the alpha 1 subunit is a determinant of gating in the glycine receptor.
    Schofield CM, Jenkins A, Harrison NL.
    J Biol Chem; 2003 Sep 05; 278(36):34079-83. PubMed ID: 12826676
    [Abstract] [Full Text] [Related]

  • 9. Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors.
    Miller PS, Da Silva HM, Smart TG.
    J Biol Chem; 2005 Nov 11; 280(45):37877-84. PubMed ID: 16144831
    [Abstract] [Full Text] [Related]

  • 10. Mutation of an arginine residue in the human glycine receptor transforms beta-alanine and taurine from agonists into competitive antagonists.
    Rajendra S, Lynch JW, Pierce KD, French CR, Barry PH, Schofield PR.
    Neuron; 1995 Jan 11; 14(1):169-75. PubMed ID: 7826634
    [Abstract] [Full Text] [Related]

  • 11. Ligand-specific conformational changes in the alpha1 glycine receptor ligand-binding domain.
    Pless SA, Lynch JW.
    J Biol Chem; 2009 Jun 05; 284(23):15847-56. PubMed ID: 19286654
    [Abstract] [Full Text] [Related]

  • 12. Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols.
    Borghese CM, Blednov YA, Quan Y, Iyer SV, Xiong W, Mihic SJ, Zhang L, Lovinger DM, Trudell JR, Homanics GE, Harris RA.
    J Pharmacol Exp Ther; 2012 Feb 05; 340(2):304-16. PubMed ID: 22037201
    [Abstract] [Full Text] [Related]

  • 13. Disruption of a putative intersubunit electrostatic bond enhances agonist efficacy at the human α1 glycine receptor.
    Welsh BT, Todorovic J, Kirson D, Allen HM, Bayly MD, Mihic SJ.
    Brain Res; 2017 Feb 15; 1657():148-155. PubMed ID: 27923639
    [Abstract] [Full Text] [Related]

  • 14. Differential agonist sensitivity of glycine receptor alpha2 subunit splice variants.
    Miller PS, Harvey RJ, Smart TG.
    Br J Pharmacol; 2004 Sep 15; 143(1):19-26. PubMed ID: 15302677
    [Abstract] [Full Text] [Related]

  • 15. Role of charged residues in coupling ligand binding and channel activation in the extracellular domain of the glycine receptor.
    Absalom NL, Lewis TM, Kaplan W, Pierce KD, Schofield PR.
    J Biol Chem; 2003 Dec 12; 278(50):50151-7. PubMed ID: 14525990
    [Abstract] [Full Text] [Related]

  • 16. Molecular determinants of proton modulation of glycine receptors.
    Chen Z, Dillon GH, Huang R.
    J Biol Chem; 2004 Jan 09; 279(2):876-83. PubMed ID: 14563849
    [Abstract] [Full Text] [Related]

  • 17. Multiple regions in the extracellular domain of the glycine receptor determine receptor activity.
    Tang B, Lummis SCR.
    J Biol Chem; 2018 Sep 07; 293(36):13889-13896. PubMed ID: 29941455
    [Abstract] [Full Text] [Related]

  • 18. Comparison of taurine- and glycine-induced conformational changes in the M2-M3 domain of the glycine receptor.
    Han NL, Clements JD, Lynch JW.
    J Biol Chem; 2004 May 07; 279(19):19559-65. PubMed ID: 14981077
    [Abstract] [Full Text] [Related]

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  • 20. Predicted structure of the extracellular region of ligand-gated ion-channel receptors shows SH2-like and SH3-like domains forming the ligand-binding site.
    Gready JE, Ranganathan S, Schofield PR, Matsuo Y, Nishikawa K.
    Protein Sci; 1997 May 07; 6(5):983-98. PubMed ID: 9144769
    [Abstract] [Full Text] [Related]

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