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Journal Abstract Search

146 related items for PubMed ID: 7657853

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  • 3. Nonpeptide angiotensin II receptor antagonists. XI. Pharmacology of EXP3174: an active metabolite of DuP 753, an orally active antihypertensive agent.
    Wong PC, Price WA, Chiu AT, Duncia JV, Carini DJ, Wexler RR, Johnson AL, Timmermans PB.
    J Pharmacol Exp Ther; 1990 Oct; 255(1):211-7. PubMed ID: 2213556
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  • 4. Drug concentration response relationships in normal volunteers after oral administration of losartan, an angiotensin II receptor antagonist.
    Munafo A, Christen Y, Nussberger J, Shum LY, Borland RM, Lee RJ, Waeber B, Biollaz J, Brunner HR.
    Clin Pharmacol Ther; 1992 May; 51(5):513-21. PubMed ID: 1587065
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  • 5. DuP 532, an angiotensin II receptor antagonist: first administration and comparison with losartan.
    Goldberg MR, Lo MW, Christ DD, Chiou R, Furtek CI, Amit O, Carides A, Biollaz J, Piguet V, Nussberger J, Brunner HR.
    Clin Pharmacol Ther; 1997 Jan; 61(1):59-69. PubMed ID: 9024174
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  • 6. Different types of receptor interaction of peptide and nonpeptide angiotensin II antagonists revealed by receptor binding and functional studies.
    Wienen W, Mauz AB, Van Meel JC, Entzeroth M.
    Mol Pharmacol; 1992 Jun; 41(6):1081-8. PubMed ID: 1614410
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  • 7. EXP3174, a metabolite of losartan (MK 954, DuP 753) is more potent than losartan in blocking the angiotensin II-induced responses in vascular smooth muscle cells.
    Sachinidis A, Ko Y, Weisser P, Meyer zu Brickwedde MK, Düsing R, Christian R, Wieczorek AJ, Vetter H.
    J Hypertens; 1993 Feb; 11(2):155-62. PubMed ID: 8385175
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  • 8. Pharmacokinetics of losartan, an angiotensin II receptor antagonist, and its active metabolite EXP3174 in humans.
    Lo MW, Goldberg MR, McCrea JB, Lu H, Furtek CI, Bjornsson TD.
    Clin Pharmacol Ther; 1995 Dec; 58(6):641-9. PubMed ID: 8529329
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  • 9. Effects of losartan on vasoconstrictor responses to angiotensin II in the forearm vascular bed of healthy volunteers.
    Baan J, Chang PC, Vermeij P, Pfaffendorf M, van Zwieten PA.
    Cardiovasc Res; 1996 Nov; 32(5):973-9. PubMed ID: 8944829
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  • 10. Simultaneous determination of a novel angiotensin II receptor blocking agent, losartan, and its metabolite in human plasma and urine by high-performance liquid chromatography.
    Furtek CI, Lo MW.
    J Chromatogr; 1992 Jan 17; 573(2):295-301. PubMed ID: 1601963
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  • 11. Angiotensin II receptor antagonists. From discovery to antihypertensive drugs.
    Timmermans PB, Carini DJ, Chiu AT, Duncia JV, Price WA, Wells GJ, Wong PC, Wexler RR, Johnson AL.
    Hypertension; 1991 Nov 17; 18(5 Suppl):III136-42. PubMed ID: 1937677
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  • 12. Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (+/-)-1-(cyclohexyloxycarbonyloxy)-ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5- yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (TCV-116).
    Shibouta Y, Inada Y, Ojima M, Wada T, Noda M, Sanada T, Kubo K, Kohara Y, Naka T, Nishikawa K.
    J Pharmacol Exp Ther; 1993 Jul 17; 266(1):114-20. PubMed ID: 8331552
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  • 13. Inhibitory effects of DuP 753 and EXP3174 on responses to angiotensin II in pulmonary vascular bed of the cat.
    McMahon TJ, Kaye AD, Hood JS, Minkes RK, Nossaman BD, Kadowitz PJ.
    J Appl Physiol (1985); 1992 Nov 17; 73(5):2054-61. PubMed ID: 1474085
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  • 14. Clinical experience with angiotensin II receptor antagonists.
    Brunner HR, Christen Y, Munafo A, Lee RJ, Waeber B, Nussberger J.
    Am J Hypertens; 1992 Dec 17; 5(12 Pt 2):243S-246S. PubMed ID: 1290619
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  • 15. BMS-180560, an insurmountable inhibitor of angiotensin II-stimulated responses: comparison with losartan and EXP3174.
    Dickinson KE, Cohen RB, Skwish S, Delaney CL, Serafino RP, Poss MA, Gu Z, Ryono DE, Moreland S, Powell JR.
    Br J Pharmacol; 1994 Sep 17; 113(1):179-89. PubMed ID: 7812609
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  • 16. Binding of [3H]angiotensin II and [3H]DuP 753 (Losartan) to rat liver homogenates reveals multiple sites. Relationship to AT1a- and AT1b-type angiotensin receptors and novel nonangiotensin binding sites.
    Widdowson PS, Renouard A, Vilaine JP.
    Peptides; 1993 Sep 17; 14(4):829-37. PubMed ID: 8234032
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  • 17. Nonpeptide angiotensin II receptor antagonist: pharmacokinetics and pharmacodynamics in rats of EXP3174, an active metabolite of losartan.
    Wong PC, Christ DD, Wong YN, Lam GN.
    Pharmacology; 1996 Jan 17; 52(1):25-9. PubMed ID: 8966199
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  • 18. In vivo pharmacology of L-158,809, a new highly potent and selective nonpeptide angiotensin II receptor antagonist.
    Siegl PK, Chang RS, Mantlo NB, Chakravarty PK, Ondeyka DL, Greenlee WJ, Patchett AA, Sweet CS, Lotti VJ.
    J Pharmacol Exp Ther; 1992 Jul 17; 262(1):139-44. PubMed ID: 1625193
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  • 19. Binding of valsartan to mammalian angiotensin AT1 receptors.
    de Gasparo M, Whitebread S.
    Regul Pept; 1995 Nov 10; 59(3):303-11. PubMed ID: 8577935
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  • 20. In vivo inhibition of angiotensin receptors in the rat kidney by candesartan cilexetil: a comparison with losartan.
    Fabiani ME, Dinh DT, Nassis L, Casley DJ, Johnston CI.
    Am J Hypertens; 2000 Sep 10; 13(9):1005-13. PubMed ID: 10981551
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