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355 related items for PubMed ID: 7687712

  • 1. The two mechanisms of action of racemic cardiotonic EMD 53998, calcium sensitization and phosphodiesterase inhibition, reside in different enantiomers.
    Lues I, Beier N, Jonas R, Klockow M, Haeusler G.
    J Cardiovasc Pharmacol; 1993 Jun; 21(6):883-92. PubMed ID: 7687712
    [Abstract] [Full Text] [Related]

  • 2. The novel cardiotonic agent EMD 53 998 is a potent "calcium sensitizer".
    Beier N, Harting J, Jonas R, Klockow M, Lues I, Haeusler G.
    J Cardiovasc Pharmacol; 1991 Jul; 18(1):17-27. PubMed ID: 1719287
    [Abstract] [Full Text] [Related]

  • 3. In vivo evidence of positive inotropism of EMD 57033 through calcium sensitization.
    Haeusler G, Jonas R, Minck KO, Schliep HJ, Schelling P, Weygandt H, Lues I.
    J Cardiovasc Pharmacol; 1997 May; 29(5):647-55. PubMed ID: 9213208
    [Abstract] [Full Text] [Related]

  • 4. EMD 53998 acts as Ca(2+)-sensitizer and phosphodiesterase III-inhibitor in human myocardium.
    Uhlmann R, Schwinger RH, Lues I, Erdmann E.
    Basic Res Cardiol; 1995 May; 90(5):365-71. PubMed ID: 8585857
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  • 5. Novel diazinone derivatives separate myofilament Ca2+ sensitization and phosphodiesterase III inhibitory effects in guinea pig myocardium.
    Ventura C, Miller R, Wolf HP, Beier N, Jonas R, Klockow M, Lues I, Hano O, Spurgeon HA, Lakatta EG.
    Circ Res; 1992 Jun; 70(6):1081-90. PubMed ID: 1533576
    [Abstract] [Full Text] [Related]

  • 6. Ca2+ sensitization in idiopathic dilated human myocardium. Differential in vitro effects of (+)-(5-methyl-6-phenyl)-1,3,5,6-tetrahydro-3,6-methano-1,5-benzodiazoci ne-2,4-dione, a novel purely Ca2+sensitizing agent, and (+)-5-(1-(3,4-dimethoxybenzoyl)-1,2,3,4-tetrahydroquinolin-6-yl)-6-meth yl-3, 6-dihydro-2H-1,3,4-thiadiazin-2-one on skinned fibres and isolated ventricular strips.
    Herzig JW, Chiesi M, Depersin H, Grüninger S, Hasenfuss G, Kubalek R, Leutert T, Pieske B, Pioch K, Wenk P, Holubarsch C.
    Arzneimittelforschung; 1996 Jun; 46(6):586-93. PubMed ID: 8767348
    [Abstract] [Full Text] [Related]

  • 7. Stereoselectivity of actions of the calcium sensitizer [+]-EMD 60263 and its enantiomer [-]-EMD 60264.
    Ravens U, Flüss OM, Li Q, Himmel HM, Wettwer E, Klockow M, Lues I.
    Naunyn Schmiedebergs Arch Pharmacol; 1997 Jun; 355(6):733-42. PubMed ID: 9205958
    [Abstract] [Full Text] [Related]

  • 8. Phosphodiesterase inhibition and Ca2+ sensitization.
    Ravens U, Himmel HM, Flüss M, Davia K, Harding SE.
    Mol Cell Biochem; 1997 Jun; 157(1-2):245-9. PubMed ID: 8739254
    [Abstract] [Full Text] [Related]

  • 9. High selectivity for inhibition of phosphodiesterase III and positive inotropic effects of MCI-154 in guinea pig myocardium.
    Bethke T, Meyer W, Schmitz W, Scholz H, Wenzlaff H, Armah BI, Brückner R, Raap A.
    J Cardiovasc Pharmacol; 1993 Jun; 21(6):847-55. PubMed ID: 7687707
    [Abstract] [Full Text] [Related]

  • 10. Two inotropes with different mechanisms of action: contractile, PDE-inhibitory and direct myofibrillar effects of levosimendan and enoximone.
    Szilágyi S, Pollesello P, Levijoki J, Haikala H, Bak I, Tósaki A, Borbély A, Edes I, Papp Z.
    J Cardiovasc Pharmacol; 2005 Sep; 46(3):369-76. PubMed ID: 16116344
    [Abstract] [Full Text] [Related]

  • 11. Enantiomeric dissection of the effects of the inotropic agent, EMD 53998, in single cardiac myocytes.
    Gambassi G, Capogrossi MC, Klockow M, Lakatta EG.
    Am J Physiol; 1993 Mar; 264(3 Pt 2):H728-38. PubMed ID: 8384421
    [Abstract] [Full Text] [Related]

  • 12. Positive inotropic effect of levosimendan is correlated to its stereoselective Ca2+-sensitizing effect but not to stereoselective phosphodiesterase inhibition.
    Kaheinen P, Pollesello P, Hertelendi Z, Borbély A, Szilágyi S, Nissinen E, Haikala H, Papp Z.
    Basic Clin Pharmacol Toxicol; 2006 Jan; 98(1):74-8. PubMed ID: 16433895
    [Abstract] [Full Text] [Related]

  • 13. Troponin C-mediated calcium sensitization by levosimendan accelerates the proportional development of isometric tension.
    Haikala H, Levijoki J, Lindén IB.
    J Mol Cell Cardiol; 1995 Oct; 27(10):2155-65. PubMed ID: 8576932
    [Abstract] [Full Text] [Related]

  • 14. Contribution of cAMP-phosphodiesterase inhibition and sensitization of the contractile proteins for calcium to the inotropic effect of pimobendan in the failing human myocardium.
    Böhm M, Morano I, Pieske B, Rüegg JC, Wankerl M, Zimmermann R, Erdmann E.
    Circ Res; 1991 Mar; 68(3):689-701. PubMed ID: 1660359
    [Abstract] [Full Text] [Related]

  • 15. Mechanism underlying the reduced positive inotropic effects of the phosphodiesterase III inhibitors pimobendan, adibendan and saterinone in failing as compared to nonfailing human cardiac muscle preparations.
    von der Leyen H, Mende U, Meyer W, Neumann J, Nose M, Schmitz W, Scholz H, Starbatty J, Stein B, Wenzlaff H.
    Naunyn Schmiedebergs Arch Pharmacol; 1991 Jul; 344(1):90-100. PubMed ID: 1723153
    [Abstract] [Full Text] [Related]

  • 16. Pharmacological and biochemical effects of the cardiotonic agent Org10325 in isolated cardiac and vascular tissue preparations.
    Shahid M, Martorana MG, Cottney JE, Marshall RJ.
    Br J Pharmacol; 1990 Aug; 100(4):735-42. PubMed ID: 2169938
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  • 20. Effects of the calcium sensitizer [+]-EMD 60263 and its enantiomer [-]-EMD 60264 on cardiac ionic currents of guinea pig and rat ventricular myocytes.
    Himmel HM, Amos GJ, Wettwer E, Ravens U.
    J Cardiovasc Pharmacol; 1999 Feb; 33(2):301-8. PubMed ID: 10028941
    [Abstract] [Full Text] [Related]

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