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122 related items for PubMed ID: 7697757

  • 1. Genotoxic effects of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) and nitrogen mustard-N-oxide (nitromin) in Walker carcinoma cells under aerobic and hypoxic conditions.
    Cahill A, Jenkins TC, Pickering P, White IN.
    Chem Biol Interact; 1995 Mar 30; 95(1-2):97-107. PubMed ID: 7697757
    [Abstract] [Full Text] [Related]

  • 2. Acute lesions in rats caused by 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) or nitromin: a comparison with rates of reduction in microsomal systems from target organs.
    White IN, Cahill A, Davies A, Carthew P.
    Arch Toxicol; 1992 Mar 30; 66(2):100-6. PubMed ID: 1605723
    [Abstract] [Full Text] [Related]

  • 3. Reduction of nitromin to nitrogen mustard: unscheduled DNA synthesis in aerobic or anaerobic rat hepatocytes, JB1, BL8 and Walker carcinoma cell lines.
    White IN, Suzanger M, Mattocks AR, Bailey E, Farmer PB, Connors TA.
    Carcinogenesis; 1989 Nov 30; 10(11):2113-8. PubMed ID: 2509092
    [Abstract] [Full Text] [Related]

  • 4. Metabolism of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) by purified DT-diaphorase under aerobic and anaerobic conditions.
    Cahill A, Jenkins TC, White IN.
    Biochem Pharmacol; 1993 Jan 26; 45(2):321-9. PubMed ID: 7679576
    [Abstract] [Full Text] [Related]

  • 5. Enzymology of the reductive bioactivation of SR 4233. A novel benzotriazine di-N-oxide hypoxic cell cytotoxin.
    Walton MI, Workman P.
    Biochem Pharmacol; 1990 Jun 01; 39(11):1735-42. PubMed ID: 2344370
    [Abstract] [Full Text] [Related]

  • 6. Reductive metabolism of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) and the induction of unscheduled DNA synthesis in rat and human derived cell lines.
    Cahill A, White IN.
    Carcinogenesis; 1990 Aug 01; 11(8):1407-11. PubMed ID: 2117504
    [Abstract] [Full Text] [Related]

  • 7. Protection against SR 4233 (Tirapazamine) aerobic cytotoxicity by the metal chelators desferrioxamine and tiron.
    Herscher LL, Krishna MC, Cook JA, Coleman CN, Biaglow JE, Tuttle SW, Gonzalez FJ, Mitchell JB.
    Int J Radiat Oncol Biol Phys; 1994 Nov 15; 30(4):879-85. PubMed ID: 7960991
    [Abstract] [Full Text] [Related]

  • 8. Molecular mechanisms of SR 4233-induced hepatocyte toxicity under aerobic versus hypoxic conditions.
    Silva JM, O'Brien PJ.
    Br J Cancer; 1993 Sep 15; 68(3):484-91. PubMed ID: 8394729
    [Abstract] [Full Text] [Related]

  • 9. Selective potentiation of the hypoxic cytotoxicity of tirapazamine by its 1-N-oxide metabolite SR 4317.
    Siim BG, Pruijn FB, Sturman JR, Hogg A, Hay MP, Brown JM, Wilson WR.
    Cancer Res; 2004 Jan 15; 64(2):736-42. PubMed ID: 14744792
    [Abstract] [Full Text] [Related]

  • 10. Toward hypoxia-selective DNA-alkylating agents built by grafting nitrogen mustards onto the bioreductively activated, hypoxia-selective DNA-oxidizing agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
    Johnson KM, Parsons ZD, Barnes CL, Gates KS.
    J Org Chem; 2014 Aug 15; 79(16):7520-31. PubMed ID: 25029663
    [Abstract] [Full Text] [Related]

  • 11. 3-amino-1,2,4-benzotriazine 4-oxide: characterization of a new metabolite arising from bioreductive processing of the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
    Fuchs T, Chowdhury G, Barnes CL, Gates KS.
    J Org Chem; 2001 Jan 12; 66(1):107-14. PubMed ID: 11429885
    [Abstract] [Full Text] [Related]

  • 12. Pharmacokinetics and bioreductive metabolism of the novel benzotriazine di-N-oxide hypoxic cell cytotoxin tirapazamine (WIN 59075; SR 4233; NSC 130181) in mice.
    Walton MI, Workman P.
    J Pharmacol Exp Ther; 1993 May 12; 265(2):938-47. PubMed ID: 8496834
    [Abstract] [Full Text] [Related]

  • 13. Detection of hypoxia by measurement of DNA damage in individual cells from spheroids and murine tumours exposed to bioreductive drugs. I. Tirapazamine.
    Olive PL.
    Br J Cancer; 1995 Mar 12; 71(3):529-36. PubMed ID: 7880735
    [Abstract] [Full Text] [Related]

  • 14. Reaction of the hypoxia-selective antitumor agent tirapazamine with a C1'-radical in single-stranded and double-stranded DNA: the drug and its metabolites can serve as surrogates for molecular oxygen in radical-mediated DNA damage reactions.
    Hwang JT, Greenberg MM, Fuchs T, Gates KS.
    Biochemistry; 1999 Oct 26; 38(43):14248-55. PubMed ID: 10571998
    [Abstract] [Full Text] [Related]

  • 15. Reductive activation of N-oxides to cause DNA strand breakage in cell lines in vitro.
    Cahill A, White IN.
    Biochem Soc Trans; 1991 Apr 26; 19(2):127S. PubMed ID: 1909655
    [No Abstract] [Full Text] [Related]

  • 16. Bioreductive metabolism of SR-4233 (WIN 59075) by whole cell suspensions under aerobic and hypoxic conditions: role of the pentose cycle and implications for the mechanism of cytotoxicity observed in air.
    Tuttle SW, Hazard L, Koch CJ, Mitchell JB, Coleman CN, Biaglow JE.
    Int J Radiat Oncol Biol Phys; 1994 May 15; 29(2):357-62. PubMed ID: 8195033
    [Abstract] [Full Text] [Related]

  • 17. Homologous recombination repair-dependent cytotoxicity of the benzotriazine di-N-oxide CEN-209: comparison with other hypoxia-activated prodrugs.
    Hunter FW, Wang J, Patel R, Hsu HL, Hickey AJ, Hay MP, Wilson WR.
    Biochem Pharmacol; 2012 Mar 01; 83(5):574-85. PubMed ID: 22182429
    [Abstract] [Full Text] [Related]

  • 18. Enzymology of the reduction of the potent benzotriazine-di-N-oxide hypoxic cell cytotoxin SR 4233 (WIN 59075) by NAD(P)H: (quinone acceptor) oxidoreductase (EC 1.6.99.2) purified from Walker 256 rat tumour cells.
    Riley RJ, Workman P.
    Biochem Pharmacol; 1992 Jan 22; 43(2):167-74. PubMed ID: 1739405
    [Abstract] [Full Text] [Related]

  • 19. Use of the comet assay to detect hypoxic cells in murine tumours and normal tissues exposed to bioreductive drugs.
    Olive PL.
    Acta Oncol; 1995 Jan 22; 34(3):301-5. PubMed ID: 7779413
    [Abstract] [Full Text] [Related]

  • 20. Hypobaric hypoxia: a method for testing bioreductive drugs in vivo.
    McAleer JJ, McKeown SR, MacManus MP, Lappin TR, Bridges JM.
    Int J Radiat Oncol Biol Phys; 1992 Jan 22; 23(3):551-5. PubMed ID: 1612955
    [Abstract] [Full Text] [Related]

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