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PUBMED FOR HANDHELDS

Journal Abstract Search

185 related items for PubMed ID: 7707325

  • 1. Reductive chemistry of the novel hypoxia-selective cytotoxin 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide.
    Palmer BD, van Zijl P, Denny WA, Wilson WR.
    J Med Chem; 1995 Mar 31; 38(7):1229-41. PubMed ID: 7707325
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  • 2. Hypoxia-selective antitumor agents. 5. Synthesis of water-soluble nitroaniline mustards with selective cytotoxicity for hypoxic mammalian cells.
    Palmer BD, Wilson WR, Cliffe S, Denny WA.
    J Med Chem; 1992 Aug 21; 35(17):3214-22. PubMed ID: 1507207
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  • 3. Hypoxia-selective antitumor agents. 3. Relationships between structure and cytotoxicity against cultured tumor cells for substituted N,N-bis(2-chloroethyl)anilines.
    Palmer BD, Wilson WR, Pullen SM, Denny WA.
    J Med Chem; 1990 Jan 21; 33(1):112-21. PubMed ID: 2296009
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  • 4. Pharmacokinetics and metabolism of the nitrogen mustard bioreductive drug 5.
    Kestell P, Pruijn FB, Siim BG, Palmer BD, Wilson WR.
    Cancer Chemother Pharmacol; 2000 Jan 21; 46(5):365-74. PubMed ID: 11127940
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  • 6. Effect of nitroreduction on the alkylating reactivity and cytotoxicity of the 2,4-dinitrobenzamide-5-aziridine CB 1954 and the corresponding nitrogen mustard SN 23862: distinct mechanisms of bioreductive activation.
    Helsby NA, Wheeler SJ, Pruijn FB, Palmer BD, Yang S, Denny WA, Wilson WR.
    Chem Res Toxicol; 2003 Apr 21; 16(4):469-78. PubMed ID: 12703963
    [Abstract] [Full Text] [Related]

  • 7. Hypoxia-selective antitumor agents. 9. Structure-activity relationships for hypoxia-selective cytotoxicity among analogues of 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide.
    Palmer BD, Wilson WR, Atwell GJ, Schultz D, Xu XZ, Denny WA.
    J Med Chem; 1994 Jul 08; 37(14):2175-84. PubMed ID: 8035424
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  • 8. Hypoxia-selective antitumor agents. 12. Nitrobenzyl quaternary salts as bioreductive prodrugs of the alkylating agent mechlorethamine.
    Tercel M, Wilson WR, Anderson RF, Denny WA.
    J Med Chem; 1996 Mar 01; 39(5):1084-94. PubMed ID: 8676343
    [Abstract] [Full Text] [Related]

  • 9. Studies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the inhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active form.
    Johansson E, Parkinson GN, Denny WA, Neidle S.
    J Med Chem; 2003 Sep 11; 46(19):4009-20. PubMed ID: 12954054
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  • 10. Bioactivation of dinitrobenzamide mustards by an E. coli B nitroreductase.
    Anlezark GM, Melton RG, Sherwood RF, Wilson WR, Denny WA, Palmer BD, Knox RJ, Friedlos F, Williams A.
    Biochem Pharmacol; 1995 Aug 25; 50(5):609-18. PubMed ID: 7669063
    [Abstract] [Full Text] [Related]

  • 11. Reduction of nitroarylmethyl quaternary ammonium prodrugs of mechlorethamine by radiation.
    Wilson WR, Ferry DM, Tercel M, Anderson RF, Denny WA.
    Radiat Res; 1998 Mar 25; 149(3):237-45. PubMed ID: 9496886
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  • 14. Nitroimidazole-based "extruded mustards' designed as reductively activated hypoxia-selective cytotoxins.
    Hay MP, Denny WA, Wilson WR.
    Anticancer Drug Des; 1996 Jul 25; 11(5):383-402. PubMed ID: 8765531
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  • 16. Synthesis and hypoxia-selective cytotoxicity of a 2-nitroimidazole mustard.
    Lee HH, Palmer BD, Wilson WR, Denny WA.
    Bioorg Med Chem Lett; 1998 Jul 07; 8(13):1741-4. PubMed ID: 9873426
    [Abstract] [Full Text] [Related]

  • 17. Synthesis and bioevaluation of a series of fatty acid esters of p-[N,N-bis(2-chloroethyl)amino]phenol.
    Wynn JE, Caldwell ML, Robinson JR, Beamer RL, Bauguess CT.
    J Pharm Sci; 1982 Jul 07; 71(7):772-6. PubMed ID: 7120060
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  • 18. Synthesis and bioevaluation of a series of alkyl ethers of p-N,N-bis(2-chloroethyl)aminophenol.
    Wise JW, Wynn JE, Beamer RL, Bauguess CT.
    J Pharm Sci; 1982 May 07; 71(5):561-5. PubMed ID: 7097504
    [Abstract] [Full Text] [Related]

  • 19. N-Substituted 2-(2,6-dinitrophenylamino)propanamides: novel prodrugs that release a primary amine via nitroreduction and intramolecular cyclization.
    Sykes BM, Atwell GJ, Hogg A, Wilson WR, O'Connor CJ, Denny WA.
    J Med Chem; 1999 Feb 11; 42(3):346-55. PubMed ID: 9986704
    [Abstract] [Full Text] [Related]

  • 20. Metabolic and radiolytic reduction of 4-alkylamino-5-nitroquinoline bioreductive drugs. Relationship to hypoxia-selective cytotoxicity.
    Siim BG, Atwell GJ, Wilson WR.
    Biochem Pharmacol; 1994 Oct 18; 48(8):1593-604. PubMed ID: 7980625
    [Abstract] [Full Text] [Related]

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