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Journal Abstract Search

162 related items for PubMed ID: 7711025

  • 21. Identification of three key residues in substrate recognition site 5 of human cytochrome P450 3A4 by cassette and site-directed mutagenesis.
    He YA, He YQ, Szklarz GD, Halpert JR.
    Biochemistry; 1997 Jul 22; 36(29):8831-9. PubMed ID: 9220969
    [Abstract] [Full Text] [Related]

  • 22. Structural flexibility and functional versatility of cytochrome P450 and rapid evolution.
    Negishi M, Iwasaki M, Juvonen RO, Sueyoshi T, Darden TA, Pedersen LG.
    Mutat Res; 1996 Feb 19; 350(1):43-50. PubMed ID: 8657195
    [Abstract] [Full Text] [Related]

  • 23. A single amino acid substitution confers progesterone 6 beta-hydroxylase activity to rabbit cytochrome P450 2C3.
    Hsu MH, Griffin KJ, Wang Y, Kemper B, Johnson EF.
    J Biol Chem; 1993 Apr 05; 268(10):6939-44. PubMed ID: 8463225
    [Abstract] [Full Text] [Related]

  • 24. Structural function of residue-209 in coumarin 7-hydroxylase (P450coh). Enzyme-kinetic studies and site-directed mutagenesis.
    Juvonen RO, Iwasaki M, Negishi M.
    J Biol Chem; 1991 Sep 05; 266(25):16431-5. PubMed ID: 1885576
    [Abstract] [Full Text] [Related]

  • 25. Substitution at residue 473 confers progesterone 21-hydroxylase activity to cytochrome P450 2C2.
    Ramarao M, Kemper B.
    Mol Pharmacol; 1995 Sep 05; 48(3):417-24. PubMed ID: 7565621
    [Abstract] [Full Text] [Related]

  • 26. Structural determinants of cytochrome P450 2B1 specificity: evidence for five substrate recognition sites.
    He Y, Luo Z, Klekotka PA, Burnett VL, Halpert JR.
    Biochemistry; 1994 Apr 12; 33(14):4419-24. PubMed ID: 8155660
    [Abstract] [Full Text] [Related]

  • 27. Interaction of aflatoxin B1 with cytochrome P450 2A5 and its mutants: correlation with metabolic activation and toxicity.
    Pelkonen P, Lang MA, Negishi M, Wild CP, Juvonen RO.
    Chem Res Toxicol; 1997 Jan 12; 10(1):85-90. PubMed ID: 9074807
    [Abstract] [Full Text] [Related]

  • 28. Structure-function analysis of CYP2A10 and CYP2A11, P450 cytochromes that differ in only eight amino acids but have strikingly different activities toward testosterone and coumarin.
    Ding X, Peng HM, Coon MJ.
    Biochem Biophys Res Commun; 1994 Aug 30; 203(1):373-8. PubMed ID: 8074681
    [Abstract] [Full Text] [Related]

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  • 30. Mutagenesis study of Asp-290 in cytochrome P450 2B11 using a fusion protein with rat NADPH-cytochrome P450 reductase.
    Harlow GR, Halpert JR.
    Arch Biochem Biophys; 1996 Feb 01; 326(1):85-92. PubMed ID: 8579377
    [Abstract] [Full Text] [Related]

  • 31. Role of residue 478 as a determinant of the substrate specificity of cytochrome P450 2B1.
    He YA, Balfour CA, Kedzie KM, Halpert JR.
    Biochemistry; 1992 Sep 29; 31(38):9220-6. PubMed ID: 1390709
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  • 32.
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  • 33. The primary sequence of cytochrome P450tyr, the multifunctional N-hydroxylase catalyzing the conversion of L-tyrosine to p-hydroxyphenylacetaldehyde oxime in the biosynthesis of the cyanogenic glucoside dhurrin in Sorghum bicolor (L.) Moench.
    Koch BM, Sibbesen O, Halkier BA, Svendsen I, Møller BL.
    Arch Biochem Biophys; 1995 Oct 20; 323(1):177-86. PubMed ID: 7487064
    [Abstract] [Full Text] [Related]

  • 34. Roles of residues 129 and 209 in the alteration by cytochrome b5 of hydroxylase activities in mouse 2A P450S.
    Juvonen RO, Iwasaki M, Negishi M.
    Biochemistry; 1992 Nov 24; 31(46):11519-23. PubMed ID: 1445886
    [Abstract] [Full Text] [Related]

  • 35. Identification of Val117 and Arg372 as critical amino acid residues for the activity difference between human CYP2A6 and CYP2A13 in coumarin 7-hydroxylation.
    He XY, Shen J, Hu WY, Ding X, Lu AY, Hong JY.
    Arch Biochem Biophys; 2004 Jul 15; 427(2):143-53. PubMed ID: 15196988
    [Abstract] [Full Text] [Related]

  • 36. Molecular modelling of the human cytochrome P450 isoform CYP2A6 and investigations of CYP2A substrate selectivity.
    Lewis DF, Dickins M, Lake BG, Eddershaw PJ, Tarbit MH, Goldfarb PS.
    Toxicology; 1999 Mar 01; 133(1):1-33. PubMed ID: 10413191
    [Abstract] [Full Text] [Related]

  • 37. Identification of residues 99, 220, and 221 of human cytochrome P450 2C19 as key determinants of omeprazole activity.
    Ibeanu GC, Ghanayem BI, Linko P, Li L, Pederson LG, Goldstein JA.
    J Biol Chem; 1996 May 24; 271(21):12496-501. PubMed ID: 8647857
    [Abstract] [Full Text] [Related]

  • 38. Replacing the carboxy-terminal 28 residues of rabbit liver P-450 (laurate (omega-1)-hydroxylase) with those of P-450 (testosterone 16 alpha-hydroxylase) produces a new stereospecific hydroxylase activity.
    Uno T, Yokota H, Imai Y.
    Biochem Biophys Res Commun; 1990 Mar 16; 167(2):498-503. PubMed ID: 2182013
    [Abstract] [Full Text] [Related]

  • 39. Homology modelling of human cytochromes P450 involved in xenobiotic metabolism and rationalization of substrate selectivity.
    Lewis DF.
    Exp Toxicol Pathol; 1999 Jul 16; 51(4-5):369-74. PubMed ID: 10445400
    [Abstract] [Full Text] [Related]

  • 40. Diclofenac and its derivatives as tools for studying human cytochromes P450 active sites: particular efficiency and regioselectivity of P450 2Cs.
    Mancy A, Antignac M, Minoletti C, Dijols S, Mouries V, Duong NT, Battioni P, Dansette PM, Mansuy D.
    Biochemistry; 1999 Oct 26; 38(43):14264-70. PubMed ID: 10572000
    [Abstract] [Full Text] [Related]

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