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Journal Abstract Search

441 related items for PubMed ID: 7761987

  • 1. The amyloid beta protein precursor mutations linked to familial Alzheimer's disease alter processing in a way that fosters amyloid deposition.
    Younkin SG.
    Tohoku J Exp Med; 1994 Nov; 174(3):217-23. PubMed ID: 7761987
    [Abstract] [Full Text] [Related]

  • 2. Production of amyloid beta protein from normal amyloid beta-protein precursor (beta APP) and the mutated beta APPS linked to familial Alzheimer's disease.
    Golde TE, Cai XD, Shoji M, Younkin SG.
    Ann N Y Acad Sci; 1993 Sep 24; 695():103-8. PubMed ID: 8239266
    [Abstract] [Full Text] [Related]

  • 3. Alpha-secretase-derived product of beta-amyloid precursor protein is decreased by presenilin 1 mutations linked to familial Alzheimer's disease.
    Ancolio K, Marambaud P, Dauch P, Checler F.
    J Neurochem; 1997 Dec 24; 69(6):2494-9. PubMed ID: 9375682
    [Abstract] [Full Text] [Related]

  • 4. An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.
    Suzuki N, Cheung TT, Cai XD, Odaka A, Otvos L, Eckman C, Golde TE, Younkin SG.
    Science; 1994 May 27; 264(5163):1336-40. PubMed ID: 8191290
    [Abstract] [Full Text] [Related]

  • 5.
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  • 6. Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease.
    Kumar-Singh S, De Jonghe C, Cruts M, Kleinert R, Wang R, Mercken M, De Strooper B, Vanderstichele H, Löfgren A, Vanderhoeven I, Backhovens H, Vanmechelen E, Kroisel PM, Van Broeckhoven C.
    Hum Mol Genet; 2000 Nov 01; 9(18):2589-98. PubMed ID: 11063718
    [Abstract] [Full Text] [Related]

  • 7. Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus.
    Thinakaran G, Teplow DB, Siman R, Greenberg B, Sisodia SS.
    J Biol Chem; 1996 Apr 19; 271(16):9390-7. PubMed ID: 8621605
    [Abstract] [Full Text] [Related]

  • 8. Evaluation of the Expression of Amyloid Precursor Protein and the Ratio of Secreted Amyloid Beta 42 to Amyloid Beta 40 in SH-SY5Y Cells Stably Transfected with Wild-Type, Single-Mutant and Double-Mutant Forms of the APP Gene for the Study of Alzheimer's Disease Pathology.
    Pahrudin Arrozi A, Shukri SNS, Wan Ngah WZ, Mohd Yusof YA, Ahmad Damanhuri MH, Makpol S.
    Appl Biochem Biotechnol; 2017 Nov 19; 183(3):853-866. PubMed ID: 28417423
    [Abstract] [Full Text] [Related]

  • 9. Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells.
    Esposito L, Gan L, Yu GQ, Essrich C, Mucke L.
    J Neurochem; 2004 Dec 19; 91(6):1260-74. PubMed ID: 15584903
    [Abstract] [Full Text] [Related]

  • 10. The phosphatidylinositol 3-kinase inhibitor wortmannin alters the metabolism of the Alzheimer's amyloid precursor protein.
    Petanceska SS, Gandy S.
    J Neurochem; 1999 Dec 19; 73(6):2316-20. PubMed ID: 10582589
    [Abstract] [Full Text] [Related]

  • 11. Processing and secretion of Alzheimer's disease amyloid precursor protein.
    Kinbara K, Kitagaki H, Kinouchi T, Okano M, Sorimachi H, Ishiura S, Suzuki K.
    Tohoku J Exp Med; 1994 Nov 19; 174(3):209-16. PubMed ID: 7761986
    [Abstract] [Full Text] [Related]

  • 12. Differential regulation of amyloid precursor protein sorting with pathological mutations results in a distinct effect on amyloid-β production.
    Lin YC, Wang JY, Wang KC, Liao JY, Cheng IH.
    J Neurochem; 2014 Nov 19; 131(4):407-12. PubMed ID: 25053581
    [Abstract] [Full Text] [Related]

  • 13. Genetic programming by the proteolytic fragments of the amyloid precursor protein: somewhere between confusion and clarity.
    Stein TD, Johnson JA.
    Rev Neurosci; 2003 Nov 19; 14(4):317-41. PubMed ID: 14640319
    [Abstract] [Full Text] [Related]

  • 14. New players in old amyloid precursor protein-processing pathways.
    Rossner S.
    Int J Dev Neurosci; 2004 Nov 19; 22(7):467-74. PubMed ID: 15465276
    [Abstract] [Full Text] [Related]

  • 15. Enhanced amyloidogenic processing of the beta-amyloid precursor protein in gene-targeted mice bearing the Swedish familial Alzheimer's disease mutations and a "humanized" Abeta sequence.
    Reaume AG, Howland DS, Trusko SP, Savage MJ, Lang DM, Greenberg BD, Siman R, Scott RW.
    J Biol Chem; 1996 Sep 20; 271(38):23380-8. PubMed ID: 8798542
    [Abstract] [Full Text] [Related]

  • 16. Differential effects of a Rab6 mutant on secretory versus amyloidogenic processing of Alzheimer's beta-amyloid precursor protein.
    McConlogue L, Castellano F, deWit C, Schenk D, Maltese WA.
    J Biol Chem; 1996 Jan 19; 271(3):1343-8. PubMed ID: 8576122
    [Abstract] [Full Text] [Related]

  • 17. Alzheimer's disease: a dysfunction of the amyloid precursor protein(1).
    Neve RL, McPhie DL, Chen Y.
    Brain Res; 2000 Dec 15; 886(1-2):54-66. PubMed ID: 11119687
    [Abstract] [Full Text] [Related]

  • 18. Alzheimer's disease.
    De-Paula VJ, Radanovic M, Diniz BS, Forlenza OV.
    Subcell Biochem; 2012 Dec 15; 65():329-52. PubMed ID: 23225010
    [Abstract] [Full Text] [Related]

  • 19. Intracellular generation of amyloid beta-protein from amyloid beta-protein precursor fragment by direct cleavage with beta- and gamma-secretase.
    Iizuka T, Shoji M, Kawarabayashi T, Sato M, Kobayashi T, Tada N, Kasai K, Matsubara E, Watanabe M, Tomidokoro Y, Hirai S.
    Biochem Biophys Res Commun; 1996 Jan 05; 218(1):238-42. PubMed ID: 8573139
    [Abstract] [Full Text] [Related]

  • 20. Generation of amyloid beta protein from its precursor is sequence specific.
    Citron M, Teplow DB, Selkoe DJ.
    Neuron; 1995 Mar 05; 14(3):661-70. PubMed ID: 7695913
    [Abstract] [Full Text] [Related]

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