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Journal Abstract Search

116 related items for PubMed ID: 7781150

  • 1. Development and validation of a sensitive solid-phase-extraction and high-performance liquid chromatography assay for the bioreductive agent tirapazamine and its major metabolites in mouse and human plasma for pharmacokinetically guided dose escalation.
    Robin H, Senan S, Workman P, Graham MA.
    Cancer Chemother Pharmacol; 1995; 36(3):266-70. PubMed ID: 7781150
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  • 2. Pharmacokinetics of the hypoxic cell cytotoxic agent tirapazamine and its major bioreductive metabolites in mice and humans: retrospective analysis of a pharmacokinetically guided dose-escalation strategy in a phase I trial.
    Graham MA, Senan S, Robin H, Eckhardt N, Lendrem D, Hincks J, Greenslade D, Rampling R, Kaye SB, von Roemeling R, Workman P.
    Cancer Chemother Pharmacol; 1997; 40(1):1-10. PubMed ID: 9137522
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  • 3. Pharmacokinetics and bioreductive metabolism of the novel benzotriazine di-N-oxide hypoxic cell cytotoxin tirapazamine (WIN 59075; SR 4233; NSC 130181) in mice.
    Walton MI, Workman P.
    J Pharmacol Exp Ther; 1993 May; 265(2):938-47. PubMed ID: 8496834
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  • 4. A column-switching high-performance liquid chromatographic assay for a novel cytotoxic thioxanthone derivative (WIN 33377) in mouse plasma with toxicokinetic results from a mouse LD10 study.
    Drozd ML, Lockwood G, Miller B, Rosi D.
    J Chromatogr B Biomed Appl; 1995 Aug 04; 670(1):145-51. PubMed ID: 7493072
    [Abstract] [Full Text] [Related]

  • 5. Microdialysis sampling with on-line microbore HPLC for the determination of tirapazamine and its reduced metabolites in rats.
    McLaughlin KJ, Faibushevich AA, Lunte CE.
    Analyst; 2000 Jan 04; 125(1):105-10. PubMed ID: 10885067
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  • 6. 3-amino-1,2,4-benzotriazine 4-oxide: characterization of a new metabolite arising from bioreductive processing of the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
    Fuchs T, Chowdhury G, Barnes CL, Gates KS.
    J Org Chem; 2001 Jan 12; 66(1):107-14. PubMed ID: 11429885
    [Abstract] [Full Text] [Related]

  • 7. Phase I and pharmacokinetic study of tirapazamine (SR 4233) administered every three weeks.
    Senan S, Rampling R, Graham MA, Wilson P, Robin H, Eckardt N, Lawson N, McDonald A, von Roemeling R, Workman P, Kaye SB.
    Clin Cancer Res; 1997 Jan 12; 3(1):31-8. PubMed ID: 9815534
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  • 8. Measurement of delivery and metabolism of tirapazamine to tumour tissue using the multilayered cell culture model.
    Kyle AH, Minchinton AI.
    Cancer Chemother Pharmacol; 1999 Jan 12; 43(3):213-20. PubMed ID: 9923551
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  • 18. SR 4233 (tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours.
    Brown JM.
    Br J Cancer; 1993 Jun 12; 67(6):1163-70. PubMed ID: 8512801
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  • 19. High-performance liquid chromatographic-ultraviolet assay for the simultaneous quantitation of BMS-181101 and its putative hydroxy metabolites in rat and monkey plasma.
    Shah VR, Srinivas NR, Campbell DA, Mantha S, Duncan G, Schuster A, Whigan DW, Shyu WC.
    Biomed Chromatogr; 1996 Jun 12; 10(3):135-8. PubMed ID: 8792865
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  • 20. Development and validation of a sensitive solid-phase extraction and high-performance liquid chromatographic assay for the novel bio-reductive anti-tumor agent RH1 in human and mouse plasma.
    Khan P, Abbas S, Hargreaves RH, Caffrey R, Megram V, McGown A.
    J Chromatogr B Biomed Sci Appl; 1999 Jun 11; 729(1-2):287-95. PubMed ID: 10410954
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