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210 related items for PubMed ID: 7791906

  • 1. Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes.
    Roach PL, Clifton IJ, Fülöp V, Harlos K, Barton GJ, Hajdu J, Andersson I, Schofield CJ, Baldwin JE.
    Nature; 1995 Jun 22; 375(6533):700-4. PubMed ID: 7791906
    [Abstract] [Full Text] [Related]

  • 2. Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation.
    Roach PL, Clifton IJ, Hensgens CM, Shibata N, Schofield CJ, Hajdu J, Baldwin JE.
    Nature; 1997 Jun 19; 387(6635):827-30. PubMed ID: 9194566
    [Abstract] [Full Text] [Related]

  • 3. Ferrous active site of isopenicillin N synthase: genetic and sequence analysis of the endogenous ligands.
    Borovok I, Landman O, Kreisberg-Zakarin R, Aharonowitz Y, Cohen G.
    Biochemistry; 1996 Feb 13; 35(6):1981-7. PubMed ID: 8639682
    [Abstract] [Full Text] [Related]

  • 4. Structural studies on the reaction of isopenicillin N synthase with the truncated substrate analogues delta-(L-alpha-aminoadipoyl)-L-cysteinyl-glycine and delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-alanine.
    Long AJ, Clifton IJ, Roach PL, Baldwin JE, Rutledge PJ, Schofield CJ.
    Biochemistry; 2005 May 03; 44(17):6619-28. PubMed ID: 15850395
    [Abstract] [Full Text] [Related]

  • 5. The reaction cycle of isopenicillin N synthase observed by X-ray diffraction.
    Burzlaff NI, Rutledge PJ, Clifton IJ, Hensgens CM, Pickford M, Adlington RM, Roach PL, Baldwin JE.
    Nature; 1999 Oct 14; 401(6754):721-4. PubMed ID: 10537113
    [Abstract] [Full Text] [Related]

  • 6. Analysis of glutamines in catalysis in Cephalosporium acremonium isopenicillin N synthase by site-directed mutagenesis.
    Loke P, Sim TS.
    Biochem Biophys Res Commun; 1998 Nov 18; 252(2):472-5. PubMed ID: 9826554
    [Abstract] [Full Text] [Related]

  • 7. A cyclobutanone analogue mimics penicillin in binding to isopenicillin N synthase.
    Stewart AC, Clifton IJ, Adlington RM, Baldwin JE, Rutledge PJ.
    Chembiochem; 2007 Nov 05; 8(16):2003-7. PubMed ID: 17907118
    [Abstract] [Full Text] [Related]

  • 8. Catalytic activity in Cephalosporium acremonium isopenicillin N synthase does not involve glutamine-234.
    Loke P, Sim TS.
    Biochem Biophys Res Commun; 1998 Jul 30; 248(3):559-61. PubMed ID: 9703965
    [Abstract] [Full Text] [Related]

  • 9. The crystal structure of an LLL-configured depsipeptide substrate analogue bound to isopenicillin N synthase.
    Ge W, Clifton IJ, Stok JE, Adlington RM, Baldwin JE, Rutledge PJ.
    Org Biomol Chem; 2010 Jan 07; 8(1):122-7. PubMed ID: 20024142
    [Abstract] [Full Text] [Related]

  • 10. Structural studies on the reaction of isopenicillin N synthase with the substrate analogue delta-(l-alpha-aminoadipoyl)-l-cysteinyl-d-alpha-aminobutyrate.
    Long AJ, Clifton IJ, Roach PL, Baldwin JE, Schofield CJ, Rutledge PJ.
    Biochem J; 2003 Jun 15; 372(Pt 3):687-93. PubMed ID: 12622704
    [Abstract] [Full Text] [Related]

  • 11. Structural studies on the reaction of isopenicillin N synthase with a sterically demanding depsipeptide substrate analogue.
    Ge W, Clifton IJ, Howard-Jones AR, Stok JE, Adlington RM, Baldwin JE, Rutledge PJ.
    Chembiochem; 2009 Aug 17; 10(12):2025-31. PubMed ID: 19598184
    [Abstract] [Full Text] [Related]

  • 12. Interactions of isopenicillin N synthase with cyclopropyl-containing substrate analogues reveal new mechanistic insight.
    Howard-Jones AR, Elkins JM, Clifton IJ, Roach PL, Adlington RM, Baldwin JE, Rutledge PJ.
    Biochemistry; 2007 Apr 24; 46(16):4755-62. PubMed ID: 17397141
    [Abstract] [Full Text] [Related]

  • 13. Isopenicillin N synthase binds δ-(L-α-aminoadipoyl)-L-cysteinyl-D-thia-allo-isoleucine through both sulfur atoms.
    Clifton IJ, Ge W, Adlington RM, Baldwin JE, Rutledge PJ.
    Chembiochem; 2011 Aug 16; 12(12):1881-5. PubMed ID: 21678539
    [Abstract] [Full Text] [Related]

  • 14. Structure of a cephalosporin synthase.
    Valegård K, van Scheltinga AC, Lloyd MD, Hara T, Ramaswamy S, Perrakis A, Thompson A, Lee HJ, Baldwin JE, Schofield CJ, Hajdu J, Andersson I.
    Nature; 1998 Aug 20; 394(6695):805-9. PubMed ID: 9723623
    [Abstract] [Full Text] [Related]

  • 15. Unexpected oxidation of a depsipeptide substrate analogue in crystalline isopenicillin N synthase.
    Daruzzaman A, Clifton IJ, Adlington RM, Baldwin JE, Rutledge PJ.
    Chembiochem; 2006 Feb 20; 7(2):351-8. PubMed ID: 16444759
    [Abstract] [Full Text] [Related]

  • 16. Unique binding of a non-natural L,L,L-substrate by isopenicillin N synthase.
    Howard-Jones AR, Rutledge PJ, Clifton IJ, Adlington RM, Baldwin JE.
    Biochem Biophys Res Commun; 2005 Oct 21; 336(2):702-8. PubMed ID: 16143309
    [Abstract] [Full Text] [Related]

  • 17. Glutamine-330 is not essential for activity in isopenicillin N synthase from Aspergillus nidulans.
    Sami M, Brown TJ, Roach PL, Schofield CJ, Baldwin JE.
    FEBS Lett; 1997 Mar 24; 405(2):191-4. PubMed ID: 9089289
    [Abstract] [Full Text] [Related]

  • 18. Isopenicillin N synthase mediates thiolate oxidation to sulfenate in a depsipeptide substrate analogue: implications for oxygen binding and a link to nitrile hydratase?
    Ge W, Clifton IJ, Stok JE, Adlington RM, Baldwin JE, Rutledge PJ.
    J Am Chem Soc; 2008 Aug 06; 130(31):10096-102. PubMed ID: 18620394
    [Abstract] [Full Text] [Related]

  • 19. PCR cloning, heterologous expression, and characterization of isopenicillin N synthase from Streptomyces lipmanii NRRL 3584.
    Loke P, Ng CP, Sim TS.
    Can J Microbiol; 2000 Feb 06; 46(2):166-70. PubMed ID: 10721485
    [Abstract] [Full Text] [Related]

  • 20. The crystal structure of an isopenicillin N synthase complex with an ethereal substrate analogue reveals water in the oxygen binding site.
    Clifton IJ, Ge W, Adlington RM, Baldwin JE, Rutledge PJ.
    FEBS Lett; 2013 Aug 19; 587(16):2705-9. PubMed ID: 23860486
    [Abstract] [Full Text] [Related]

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