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213 related items for PubMed ID: 7808429

  • 1. Catalytic selectivity and mechanism-based inactivation of stably expressed and hepatic cytochromes P450 2B4 and 2B5: implications of the cytochrome P450 2B5 polymorphism.
    Grimm SW, Dyroff MC, Philpot RM, Halpert JR.
    Mol Pharmacol; 1994 Dec; 46(6):1090-9. PubMed ID: 7808429
    [Abstract] [Full Text] [Related]

  • 2. Selectivity and kinetics of inactivation of rabbit hepatic cytochromes P450 2B4 and 2B5 by N-aralkylated derivatives of 1-aminobenzotriazole.
    Grimm SW, Bend JR, Halpert JR.
    Drug Metab Dispos; 1995 May; 23(5):577-83. PubMed ID: 7587934
    [Abstract] [Full Text] [Related]

  • 3. Interconversion of the androstenedione hydroxylase specificities of cytochromes P450 2B4 and 2B5 upon simultaneous site-directed mutagenesis of four key substrate recognition residues.
    He YQ, Szklarz GD, Halpert JR.
    Arch Biochem Biophys; 1996 Nov 01; 335(1):152-60. PubMed ID: 8914846
    [Abstract] [Full Text] [Related]

  • 4. Elucidation of amino acid residues critical for unique activities of rabbit cytochrome P450 2B5 using hybrid enzymes and reciprocal site-directed mutagenesis with rabbit cytochrome P450 2B4.
    Szklarz GD, He YQ, Kedzie KM, Halpert JR, Burnett VL.
    Arch Biochem Biophys; 1996 Mar 15; 327(2):308-18. PubMed ID: 8619620
    [Abstract] [Full Text] [Related]

  • 5. Role of residue 480 in substrate specificity of cytochrome P450 2B5 and 2B11.
    Liu J, He YA, Halpert JR.
    Arch Biochem Biophys; 1996 Mar 01; 327(1):167-73. PubMed ID: 8615687
    [Abstract] [Full Text] [Related]

  • 6. Structural determinants of progesterone hydroxylation by cytochrome P450 2B5: the role of nonsubstrate recognition site residues.
    He YQ, Harlow GR, Szklarz GD, Halpert JR.
    Arch Biochem Biophys; 1998 Feb 15; 350(2):333-9. PubMed ID: 9473309
    [Abstract] [Full Text] [Related]

  • 7. Identification of selective mechanism-based inactivators of cytochromes P-450 2B4 and 2B5, and determination of the molecular basis for differential susceptibility.
    Strobel SM, Szklarz GD, He Y, Foroozesh M, Alworth WL, Roberts ES, Hollenberg PF, Halpert JR.
    J Pharmacol Exp Ther; 1999 Jul 15; 290(1):445-51. PubMed ID: 10381811
    [Abstract] [Full Text] [Related]

  • 8. Escherichia coli expression and characterization of cytochromes P450 2B11, 2B1, and 2B5.
    John GH, Hasler JA, He YA, Halpert JR.
    Arch Biochem Biophys; 1994 Nov 01; 314(2):367-75. PubMed ID: 7979377
    [Abstract] [Full Text] [Related]

  • 9. Cloning, sequencing, and functional studies of phenobarbital-inducible forms of cytochrome P450 2B and 4B expressed in rabbit kidney.
    Ryan R, Grimm SW, Kedzie KM, Halpert JR, Philpot RM.
    Arch Biochem Biophys; 1993 Aug 01; 304(2):454-63. PubMed ID: 8346920
    [Abstract] [Full Text] [Related]

  • 10. Subcellular localization, aggregation state, and catalytic activity of microsomal P450 cytochromes modified in the NH2-terminal region and expressed in Escherichia coli.
    Pernecky SJ, Olken NM, Bestervelt LL, Coon MJ.
    Arch Biochem Biophys; 1995 Apr 20; 318(2):446-56. PubMed ID: 7733676
    [Abstract] [Full Text] [Related]

  • 11. Site-directed mutagenesis of putative substrate recognition sites in cytochrome P450 2B11: importance of amino acid residues 114, 290, and 363 for substrate specificity.
    Hasler JA, Harlow GR, Szklarz GD, John GH, Kedzie KM, Burnett VL, He YA, Kaminsky LS, Halpert JR.
    Mol Pharmacol; 1994 Aug 20; 46(2):338-45. PubMed ID: 8078495
    [Abstract] [Full Text] [Related]

  • 12. A role for threonine 302 in the mechanism-based inactivation of P450 2B4 by 2-ethynylnaphthalene.
    Roberts ES, Pernecky SJ, Alworth WL, Hollenberg PF.
    Arch Biochem Biophys; 1996 Jul 15; 331(2):170-6. PubMed ID: 8660695
    [Abstract] [Full Text] [Related]

  • 13. Monoclonal antibodies inhibitory to rat hepatic cytochromes P-450: P-450 form specificities and use as probes for cytochrome P-450-dependent steroid hydroxylations.
    Waxman DJ, Lapenson DP, Park SS, Attisano C, Gelboin HV.
    Mol Pharmacol; 1987 Nov 15; 32(5):615-24. PubMed ID: 3119986
    [Abstract] [Full Text] [Related]

  • 14. Expression of truncated forms of liver microsomal P450 cytochromes 2B4 and 2E1 in Escherichia coli: influence of NH2-terminal region on localization in cytosol and membranes.
    Pernecky SJ, Larson JR, Philpot RM, Coon MJ.
    Proc Natl Acad Sci U S A; 1993 Apr 01; 90(7):2651-5. PubMed ID: 8464872
    [Abstract] [Full Text] [Related]

  • 15. Peroxo-iron and oxenoid-iron species as alternative oxygenating agents in cytochrome P450-catalyzed reactions: switching by threonine-302 to alanine mutagenesis of cytochrome P450 2B4.
    Vaz AD, Pernecky SJ, Raner GM, Coon MJ.
    Proc Natl Acad Sci U S A; 1996 May 14; 93(10):4644-8. PubMed ID: 8643457
    [Abstract] [Full Text] [Related]

  • 16. Selective inactivation of four rat liver microsomal androstenedione hydroxylases by chloramphenicol analogs.
    Stevens JC, Halpert J.
    Mol Pharmacol; 1988 Jan 14; 33(1):103-10. PubMed ID: 3336347
    [Abstract] [Full Text] [Related]

  • 17. Activation of the anticancer prodrugs cyclophosphamide and ifosfamide: identification of cytochrome P450 2B enzymes and site-specific mutants with improved enzyme kinetics.
    Chen CS, Lin JT, Goss KA, He YA, Halpert JR, Waxman DJ.
    Mol Pharmacol; 2004 May 14; 65(5):1278-85. PubMed ID: 15102956
    [Abstract] [Full Text] [Related]

  • 18. Aryl acetylenes as mechanism-based inhibitors of cytochrome P450-dependent monooxygenase enzymes.
    Foroozesh M, Primrose G, Guo Z, Bell LC, Alworth WL, Guengerich FP.
    Chem Res Toxicol; 1997 Jan 14; 10(1):91-102. PubMed ID: 9074808
    [Abstract] [Full Text] [Related]

  • 19. Inhibition and inactivation of constitutive cytochromes P450 in rat liver by parathion.
    Butler AM, Murray M.
    Mol Pharmacol; 1993 Jun 14; 43(6):902-8. PubMed ID: 8316222
    [Abstract] [Full Text] [Related]

  • 20. Mechanism-based inactivation of cytochromes P450 2B1 and P450 2B6 by 2-phenyl-2-(1-piperidinyl)propane.
    Chun J, Kent UM, Moss RM, Sayre LM, Hollenberg PF.
    Drug Metab Dispos; 2000 Aug 14; 28(8):905-11. PubMed ID: 10901699
    [Abstract] [Full Text] [Related]

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