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Journal Abstract Search

218 related items for PubMed ID: 7853394

  • 1. Structure of a retro-binding peptide inhibitor complexed with human alpha-thrombin.
    Tabernero L, Chang CY, Ohringer SL, Lau WF, Iwanowicz EJ, Han WC, Wang TC, Seiler SM, Roberts DG, Sack JS.
    J Mol Biol; 1995 Feb 10; 246(1):14-20. PubMed ID: 7853394
    [Abstract] [Full Text] [Related]

  • 2. Hirunorms are true hirudin mimetics. The crystal structure of human alpha-thrombin-hirunorm V complex.
    De Simone G, Lombardi A, Galdiero S, Nastri F, Della Morte R, Staiano N, Pedone C, Bolognesi M, Pavone V.
    Protein Sci; 1998 Feb 10; 7(2):243-53. PubMed ID: 9521099
    [Abstract] [Full Text] [Related]

  • 3. Crystallographic determination of the structures of human alpha-thrombin complexed with BMS-186282 and BMS-189090.
    Malley MF, Tabernero L, Chang CY, Ohringer SL, Roberts DG, Das J, Sack JS.
    Protein Sci; 1996 Feb 10; 5(2):221-8. PubMed ID: 8745399
    [Abstract] [Full Text] [Related]

  • 4. The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin.
    Vijayalakshmi J, Padmanabhan KP, Mann KG, Tulinsky A.
    Protein Sci; 1994 Dec 10; 3(12):2254-71. PubMed ID: 7756983
    [Abstract] [Full Text] [Related]

  • 5. Structures of thrombin complexes with a designed and a natural exosite peptide inhibitor.
    Qiu X, Yin M, Padmanabhan KP, Krstenansky JL, Tulinsky A.
    J Biol Chem; 1993 Sep 25; 268(27):20318-26. PubMed ID: 8376390
    [Abstract] [Full Text] [Related]

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  • 7. Bifunctional peptide boronate inhibitors of thrombin: crystallographic analysis of inhibition enhanced by linkage to an exosite 1 binding peptide.
    Skordalakes E, Elgendy S, Goodwin CA, Green D, Scully MF, Kakkar VV, Freyssinet JM, Dodson G, Deadman JJ.
    Biochemistry; 1998 Oct 13; 37(41):14420-7. PubMed ID: 9772168
    [Abstract] [Full Text] [Related]

  • 8. Structure of the hirugen and hirulog 1 complexes of alpha-thrombin.
    Skrzypczak-Jankun E, Carperos VE, Ravichandran KG, Tulinsky A, Westbrook M, Maraganore JM.
    J Mol Biol; 1991 Oct 20; 221(4):1379-93. PubMed ID: 1942057
    [Abstract] [Full Text] [Related]

  • 9. Crystal structure of two new bifunctional nonsubstrate type thrombin inhibitors complexed with human alpha-thrombin.
    Féthière J, Tsuda Y, Coulombe R, Konishi Y, Cygler M.
    Protein Sci; 1996 Jun 20; 5(6):1174-83. PubMed ID: 8762149
    [Abstract] [Full Text] [Related]

  • 10. Molecular modeling studies of novel retro-binding tripeptide active-site inhibitors of thrombin.
    Lau WF, Tabernero L, Sack JS, Iwanowicz EJ.
    Bioorg Med Chem; 1995 Aug 20; 3(8):1039-48. PubMed ID: 7582978
    [Abstract] [Full Text] [Related]

  • 11. Human alpha-thrombin inhibition by the active site titrant N alpha-(N,N-dimethylcarbamoyl)-alpha-azalysine p-nitrophenyl ester: a comparative kinetic and X-ray crystallographic study.
    Nardini M, Pesce A, Rizzi M, Casale E, Ferraccioli R, Balliano G, Milla P, Ascenzi P, Bolognesi M.
    J Mol Biol; 1996 May 24; 258(5):851-9. PubMed ID: 8637015
    [Abstract] [Full Text] [Related]

  • 12. Structure of thrombin complexed with selective non-electrophilic inhibitors having cyclohexyl moieties at P1.
    Krishnan R, Mochalkin I, Arni R, Tulinsky A.
    Acta Crystallogr D Biol Crystallogr; 2000 Mar 24; 56(Pt 3):294-303. PubMed ID: 10713516
    [Abstract] [Full Text] [Related]

  • 13. Structure-activity relationships of recombinant hirudins.
    Stürzebecher J, Walsmann P.
    Semin Thromb Hemost; 1991 Apr 24; 17(2):94-8. PubMed ID: 1771418
    [Abstract] [Full Text] [Related]

  • 14. Crystal structure of the thrombin-hirudin complex: a novel mode of serine protease inhibition.
    Grütter MG, Priestle JP, Rahuel J, Grossenbacher H, Bode W, Hofsteenge J, Stone SR.
    EMBO J; 1990 Aug 24; 9(8):2361-5. PubMed ID: 2369893
    [Abstract] [Full Text] [Related]

  • 15. Synthesis, structure, and structure-activity relationships of divalent thrombin inhibitors containing an alpha-keto-amide transition-state mimetic.
    Krishnan R, Tulinsky A, Vlasuk GP, Pearson D, Vallar P, Bergum P, Brunck TK, Ripka WC.
    Protein Sci; 1996 Mar 24; 5(3):422-33. PubMed ID: 8868478
    [Abstract] [Full Text] [Related]

  • 16. Crystal structure of the complex of human alpha-thrombin and nonhydrolyzable bifunctional inhibitors, hirutonin-2 and hirutonin-6.
    Zdanov A, Wu S, DiMaio J, Konishi Y, Li Y, Wu X, Edwards BF, Martin PD, Cygler M.
    Proteins; 1993 Nov 24; 17(3):252-65. PubMed ID: 8272424
    [Abstract] [Full Text] [Related]

  • 17. The crystal structure of human alpha-thrombin complexed with LY178550, a nonpeptidyl, active site-directed inhibitor.
    Chirgadze NY, Sall DJ, Klimkowski VJ, Clawson DK, Briggs SL, Hermann R, Smith GF, Gifford-Moore DS, Wery JP.
    Protein Sci; 1997 Jul 24; 6(7):1412-7. PubMed ID: 9232642
    [Abstract] [Full Text] [Related]

  • 18. Refined structure of the hirudin-thrombin complex.
    Rydel TJ, Tulinsky A, Bode W, Huber R.
    J Mol Biol; 1991 Sep 20; 221(2):583-601. PubMed ID: 1920434
    [Abstract] [Full Text] [Related]

  • 19. Proteolytic formation of either of the two prothrombin activation intermediates results in formation of a hirugen-binding site.
    Liu LW, Ye J, Johnson AE, Esmon CT.
    J Biol Chem; 1991 Dec 15; 266(35):23633-6. PubMed ID: 1748641
    [Abstract] [Full Text] [Related]

  • 20. Crystallographic structure of a peptidyl keto acid inhibitor and human alpha-thrombin.
    Håkansson K, Tulinsky A, Abelman MM, Miller TA, Vlasuk GP, Bergum PW, Lim-Wilby MS, Brunck TK.
    Bioorg Med Chem; 1995 Aug 15; 3(8):1009-17. PubMed ID: 7582975
    [Abstract] [Full Text] [Related]

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