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Journal Abstract Search

334 related items for PubMed ID: 7880376

  • 1. Structure-activity relationship of a series of nitrogen mustard- and pyrrole-containing minor groove-binding agents related to distamycin.
    Wyatt MD, Garbiras BJ, Haskell MK, Lee M, Souhami RL, Hartley JA.
    Anticancer Drug Des; 1994 Dec; 9(6):511-25. PubMed ID: 7880376
    [Abstract] [Full Text] [Related]

  • 2. Design, synthesis, and biological evaluation of DNA sequence and minor groove selective alkylating agents.
    Lee M, Rhodes AL, Wyatt MD, Forrow S, Hartley JA.
    Anticancer Drug Des; 1993 Jun; 8(3):173-92. PubMed ID: 8517912
    [Abstract] [Full Text] [Related]

  • 3. Sequence specificity of alkylation for a series of nitrogen mustard-containing analogues of distamycin of increasing binding site size: evidence for increased cytotoxicity with enhanced sequence specificity.
    Wyatt MD, Lee M, Garbiras BJ, Souhami RL, Hartley JA.
    Biochemistry; 1995 Oct 10; 34(40):13034-41. PubMed ID: 7548062
    [Abstract] [Full Text] [Related]

  • 4. The role of base excision repair in the repair of DNA adducts formed by a series of nitrogen mustard-containing analogues of distamycin of increasing binding site size.
    Brooks N, McHugh PJ, Lee M, Hartley JA.
    Anticancer Drug Des; 1999 Feb 10; 14(1):11-8. PubMed ID: 10363024
    [Abstract] [Full Text] [Related]

  • 5. Synthesis, DNA binding, cytotoxicity and sequence specificity of a series of imidazole-containing analogs of the benzoic acid mustard distamycin derivative tallimustine containing an alkylating group at the C-terminus.
    Brooks N, Lee M, Wright SR, Woo S, Centioni S, Hartley JA.
    Anticancer Drug Des; 1997 Oct 10; 12(7):591-606. PubMed ID: 9365504
    [Abstract] [Full Text] [Related]

  • 6. Sequence selectivity, cross-linking efficiency and cytotoxicity of DNA-targeted 4-anilinoquinoline aniline mustards.
    McClean S, Costelloe C, Denny WA, Searcey M, Wakelin LP.
    Anticancer Drug Des; 1999 Jun 10; 14(3):187-204. PubMed ID: 10500495
    [Abstract] [Full Text] [Related]

  • 7. Alkylation specificity for a series of distamycin analogues that tether chlorambucil.
    Wyatt MD, Lee M, Hartley JA.
    Anticancer Drug Des; 1997 Jan 10; 12(1):49-60. PubMed ID: 9051113
    [Abstract] [Full Text] [Related]

  • 8. Design, synthesis and biological evaluation of benzoic acid mustard derivatives of imidazole-containing and C-terminal carboxamide analogues of distamycin.
    Hartley JA, Preti CS, Wyatt MD, Lee M.
    Drug Des Discov; 1995 Apr 10; 12(4):323-35. PubMed ID: 9040992
    [Abstract] [Full Text] [Related]

  • 9. In vitro cytotoxicity of GC sequence directed alkylating agents related to distamycin.
    Lee M, Rhodes AL, Wyatt MD, D'Incalci M, Forrow S, Hartley JA.
    J Med Chem; 1993 Apr 02; 36(7):863-70. PubMed ID: 8464041
    [Abstract] [Full Text] [Related]

  • 10. Structure-activity relationship of a series of C-terminus modified aminoalkyl, diaminoalkyl- and anilino-containing analogues of the benzoic acid mustard distamycin derivative tallimustine: synthesis, DNA binding and cytotoxicity studies.
    Brooks N, Hartley JA, Simpson JE, Wright SR, Woo S, Centioni S, Fontaine MD, McIntyre TE, Lee M.
    Bioorg Med Chem; 1997 Aug 02; 5(8):1497-507. PubMed ID: 9313856
    [Abstract] [Full Text] [Related]

  • 11. DNA binding properties of novel distamycin analogs that lack the leading amide unit at the N-terminus.
    Bhattacharya S, Thomas M.
    Biochem Biophys Res Commun; 2000 Jan 07; 267(1):139-44. PubMed ID: 10623588
    [Abstract] [Full Text] [Related]

  • 12. The effects of a benzoic acid mustard derivative of distamycin A (FCE 24517) and related minor groove-binding distamycin analogues on the activity of major groove-binding alkylating agents.
    Coley HM, Mongelli N, D'Incalci M.
    Biochem Pharmacol; 1993 Feb 09; 45(3):619-26. PubMed ID: 8442762
    [Abstract] [Full Text] [Related]

  • 13. DNA-Directed alkylating agents. 7. Synthesis, DNA interaction, and antitumor activity of bis(hydroxymethyl)- and bis(carbamate)-substituted pyrrolizines and imidazoles.
    Atwell GJ, Fan JY, Tan K, Denny WA.
    J Med Chem; 1998 Nov 19; 41(24):4744-54. PubMed ID: 9822545
    [Abstract] [Full Text] [Related]

  • 14. Sequence-specific DNA alkylation of novel tallimustine derivatives.
    Marchini S, Cozzi P, Beria I, Geroni C, Capolongo L, D'Incalci M, Broggini M.
    Anticancer Drug Des; 1998 Apr 19; 13(3):193-205. PubMed ID: 9595033
    [Abstract] [Full Text] [Related]

  • 15. The sequence specificity of alkylation for a series of benzoic acid mustard and imidazole-containing distamycin analogues: the importance of local sequence conformation.
    Wyatt MD, Lee M, Hartley JA.
    Nucleic Acids Res; 1997 Jun 15; 25(12):2359-64. PubMed ID: 9171086
    [Abstract] [Full Text] [Related]

  • 16. Synthesis and biophysical evaluation of minor-groove binding C-terminus modified pyrrole and imidazole triamide analogs of distamycin.
    Brown T, Taherbhai Z, Sexton J, Sutterfield A, Turlington M, Jones J, Stallings L, Stewart M, Buchmueller K, Mackay H, O'hare C, Kluza J, Nguyen B, Wilson D, Lee M, Hartley JA.
    Bioorg Med Chem; 2007 Jan 01; 15(1):474-83. PubMed ID: 17035029
    [Abstract] [Full Text] [Related]

  • 17. Selective DNA interaction of the novel distamycin derivative FCE 24517.
    Broggini M, Erba E, Ponti M, Ballinari D, Geroni C, Spreafico F, D'Incalci M.
    Cancer Res; 1991 Jan 01; 51(1):199-204. PubMed ID: 1859575
    [Abstract] [Full Text] [Related]

  • 18. In vitro photoinduced cytotoxicity and DNA binding properties of psoralen and coumarin conjugates of netropsin analogues: DNA sequence-directed alkylation and cross-link formation.
    Lee M, Roldan MC, Haskell MK, McAdam SR, Hartley JA.
    J Med Chem; 1994 Apr 15; 37(8):1208-13. PubMed ID: 8164263
    [Abstract] [Full Text] [Related]

  • 19. Unusual DNA binding exhibited by synthetic distamycin analogues lacking the N-terminal amide unit under high salt conditions.
    Thomas M, Rao AR, Varshney U, Bhattacharya S.
    J Biomol Struct Dyn; 2001 Jun 15; 18(6):858-71. PubMed ID: 11444374
    [Abstract] [Full Text] [Related]

  • 20. Pyrazole analogues of the bispyrrolecarboxamide anti-tumour antibiotics: synthesis, DNA binding and anti-tumour properties.
    Lee HH, Boyd M, Gravatt GL, Denny WA.
    Anticancer Drug Des; 1991 Nov 15; 6(5):501-17. PubMed ID: 1662514
    [Abstract] [Full Text] [Related]

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