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Journal Abstract Search

101 related items for PubMed ID: 7882328

  • 1. Novel antitumor indolocarbazole compound 6-N-formylamino-12,13-dihydro-1,11- dihydroxy-13-(beta-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo[3,4- c]carbazole-5,7(6H)-dione (NB-506): induction of topoisomerase I-mediated DNA cleavage and mechanisms of cell line-selective cytotoxicity.
    Yoshinari T, Matsumoto M, Arakawa H, Okada H, Noguchi K, Suda H, Okura A, Nishimura S.
    Cancer Res; 1995 Mar 15; 55(6):1310-5. PubMed ID: 7882328
    [Abstract] [Full Text] [Related]

  • 2. Novel indolocarbazole compound 6-N-formylamino-12,13-dihydro-1,11-dihydroxy- 13-(beta-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo-[3,4-c]carbazole- 5,7(6H)-dione (NB-506): its potent antitumor activities in mice.
    Arakawa H, Iguchi T, Morita M, Yoshinari T, Kojiri K, Suda H, Okura A, Nishimura S.
    Cancer Res; 1995 Mar 15; 55(6):1316-20. PubMed ID: 7882329
    [Abstract] [Full Text] [Related]

  • 3. A new mechanism of acquisition of drug resistance by partial duplication of topoisomerase I.
    Komatani H, Morita M, Sakaizumi N, Fukasawa K, Yoshida E, Okura A, Yoshinari T, Nishimura S.
    Cancer Res; 1999 Jun 01; 59(11):2701-8. PubMed ID: 10363995
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  • 4. Mode of action of a new indolocarbazole anticancer agent, J-107088, targeting topoisomerase I.
    Yoshinari T, Ohkubo M, Fukasawa K, Egashira S, Hara Y, Matsumoto M, Nakai K, Arakawa H, Morishima H, Nishimura S.
    Cancer Res; 1999 Sep 01; 59(17):4271-5. PubMed ID: 10485471
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  • 5. Cellular determinants of resistance to indolocarbazole analogue 6-N-formylamino-12,13-dihydro-1,11-dihydroxy-13(beta-D-glucopyranosyl)- 5H-indolo[2,3-alpha]pyrrolo[3,4-c]carbazole-5,7(6H)-dione (NB-506), a novel potent topoisomerase I inhibitor, in multidrug-resistant human tumor cells.
    Vanhoefer U, Voigt W, Hilger RA, Yin MB, Harstrick A, Seeber S, Rustum YM.
    Oncol Res; 1997 Sep 01; 9(9):485-94. PubMed ID: 9495454
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  • 6. Substitution at the F-ring N-imide of the indolocarbazole antitumor drug NB-506 increases the cytotoxicity, DNA binding, and topoisomerase I inhibition activities.
    Bailly C, Qu X, Chaires JB, Colson P, Houssier C, Ohkubo M, Nishimura S, Yoshinari T.
    J Med Chem; 1999 Jul 29; 42(15):2927-35. PubMed ID: 10425102
    [Abstract] [Full Text] [Related]

  • 7. In vitro metabolism of a new anticancer agent, 6-N-formylamino-12, 13-dihydro-1,11-dihydroxy-13-(beta-D-glucopyranosil)5H-indolo+ ++[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione (NB-506), in mice, rats, dogs, and humans.
    Takenaga N, Hasegawa T, Ishii M, Ishizaki H, Hata S, Kamei T.
    Drug Metab Dispos; 1999 Feb 29; 27(2):213-20. PubMed ID: 9929505
    [Abstract] [Full Text] [Related]

  • 8. Intercalation into DNA is not required for inhibition of topoisomerase I by indolocarbazole antitumor agents.
    Bailly C, Dassonneville L, Colson P, Houssier C, Fukasawa K, Nishimura S, Yoshinari T.
    Cancer Res; 1999 Jun 15; 59(12):2853-60. PubMed ID: 10383146
    [Abstract] [Full Text] [Related]

  • 9. In vivo metabolism of a new anticancer agent, 6-N-formylamino-12, 13-dihydro-1,11-dihydroxy-13-(beta-D-glucopyranosil)5H-indolo [2,3-a]pyrrolo [3,4-c]carbazole-5,7(6H)-dione (NB-506) in rats and dogs: pharmacokinetics, isolation, identification, and quantification of metabolites.
    Takenaga N, Ishii M, Nakajima S, Hasegawa T, Iwasa R, Ishizaki H, Kamei T.
    Drug Metab Dispos; 1999 Feb 15; 27(2):205-12. PubMed ID: 9929504
    [Abstract] [Full Text] [Related]

  • 10. A DNA binding indolocarbazole disaccharide derivative remains highly cytotoxic without inhibiting topoisomerase I.
    Qu X, Chaires JB, Ohkubo M, Yoshinari T, Nishimura S, Bailly C.
    Anticancer Drug Des; 1999 Oct 15; 14(5):433-42. PubMed ID: 10766298
    [Abstract] [Full Text] [Related]

  • 11. Use of camptothecin-resistant mammalian cell lines to evaluate the role of topoisomerase I in the antiproliferative activity of the indolocarbazole, NB-506, and its topoisomerase I binding site.
    Urasaki Y, Laco G, Takebayashi Y, Bailly C, Kohlhagen G, Pommier Y.
    Cancer Res; 2001 Jan 15; 61(2):504-8. PubMed ID: 11212241
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  • 16. Specific inhibition of serine- and arginine-rich splicing factors phosphorylation, spliceosome assembly, and splicing by the antitumor drug NB-506.
    Pilch B, Allemand E, Facompré M, Bailly C, Riou JF, Soret J, Tazi J.
    Cancer Res; 2001 Sep 15; 61(18):6876-84. PubMed ID: 11559564
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  • 18. DNA binding properties of the indolocarbazole antitumor drug NB-506.
    Carrasco C, Vezin H, Wilson WD, Ren J, Chaires JB, Bailly C.
    Anticancer Drug Des; 2001 Sep 15; 16(2-3):99-107. PubMed ID: 11962518
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  • 19. Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl group.
    Anizon F, Belin L, Moreau P, Sancelme M, Voldoire A, Prudhomme M, Ollier M, Sevère D, Riou JF, Bailly C, Fabbro D, Meyer T.
    J Med Chem; 1997 Oct 10; 40(21):3456-65. PubMed ID: 9341921
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  • 20. Indolocarbazole glycosides in inactive conformations.
    Facompré M, Carrasco C, Vezin H, Chisholm JD, Yoburn JC, Van Vranken DL, Bailly C.
    Chembiochem; 2003 May 09; 4(5):386-95. PubMed ID: 12740810
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