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Journal Abstract Search

112 related items for PubMed ID: 7893672

  • 1. Kinetic and crystallographic studies of thrombin with Ac-(D)Phe-Pro-boroArg-OH and its lysine, amidine, homolysine, and ornithine analogs.
    Weber PC, Lee SL, Lewandowski FA, Schadt MC, Chang CW, Kettner CA.
    Biochemistry; 1995 Mar 21; 34(11):3750-7. PubMed ID: 7893672
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  • 2. Structure-based understanding of ligand affinity using human thrombin as a model system.
    Nienaber VL, Mersinger LJ, Kettner CA.
    Biochemistry; 1996 Jul 30; 35(30):9690-9. PubMed ID: 8703940
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  • 3. The solution conformation of (D)Phe-Pro-containing peptides: implications on the activity of Ac-(D)Phe-Pro-boroArg-OH, a potent thrombin inhibitor.
    Lim MS, Johnston ER, Kettner CA.
    J Med Chem; 1993 Jun 25; 36(13):1831-8. PubMed ID: 8515421
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  • 4. Biochemical and crystallographic characterization of homologous non-peptidic thrombin inhibitors having alternate binding modes.
    Strickland CL, Fevig JM, Galemmo RA, Wells BL, Kettner CA, Weber PC.
    Acta Crystallogr D Biol Crystallogr; 1998 Nov 01; 54(Pt 6 Pt 2):1207-15. PubMed ID: 10089499
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  • 5. Bifunctional peptide boronate inhibitors of thrombin: crystallographic analysis of inhibition enhanced by linkage to an exosite 1 binding peptide.
    Skordalakes E, Elgendy S, Goodwin CA, Green D, Scully MF, Kakkar VV, Freyssinet JM, Dodson G, Deadman JJ.
    Biochemistry; 1998 Oct 13; 37(41):14420-7. PubMed ID: 9772168
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  • 6. The selective inhibition of thrombin by peptides of boroarginine.
    Kettner C, Mersinger L, Knabb R.
    J Biol Chem; 1990 Oct 25; 265(30):18289-97. PubMed ID: 2211702
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  • 7. Selection of S18326 as a new potent and selective boronic acid direct thrombin inhibitor.
    Rupin A, Mennecier P, Lila C, de Nanteuil G, Verbeuren TJ.
    Thromb Haemost; 1997 Oct 25; 78(4):1221-7. PubMed ID: 9364988
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  • 9. 11B NMR spectroscopy of peptide boronic acid inhibitor complexes of alpha-lytic protease. Direct evidence for tetrahedral boron in both boron-histidine and boron-serine adduct complexes.
    Tsilikounas E, Kettner CA, Bachovchin WW.
    Biochemistry; 1993 Nov 30; 32(47):12651-5. PubMed ID: 8251483
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  • 13. Crystallographic determination of the structures of human alpha-thrombin complexed with BMS-186282 and BMS-189090.
    Malley MF, Tabernero L, Chang CY, Ohringer SL, Roberts DG, Das J, Sack JS.
    Protein Sci; 1996 Feb 30; 5(2):221-8. PubMed ID: 8745399
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  • 14. In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design.
    Costanzo MJ, Almond HR, Hecker LR, Schott MR, Yabut SC, Zhang HC, Andrade-Gordon P, Corcoran TW, Giardino EC, Kauffman JA, Lewis JM, de Garavilla L, Haertlein BJ, Maryanoff BE.
    J Med Chem; 2005 Mar 24; 48(6):1984-2008. PubMed ID: 15771442
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  • 15. Structures of thrombin retro-inhibited with SEL2711 and SEL2770 as they relate to factor Xa binding.
    Mochalkin I, Tulinsky A.
    Acta Crystallogr D Biol Crystallogr; 1999 Apr 24; 55(Pt 4):785-93. PubMed ID: 10089309
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  • 17. A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.
    Katz BA, Elrod K, Luong C, Rice MJ, Mackman RL, Sprengeler PA, Spencer J, Hataye J, Janc J, Link J, Litvak J, Rai R, Rice K, Sideris S, Verner E, Young W.
    J Mol Biol; 2001 Apr 13; 307(5):1451-86. PubMed ID: 11292354
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  • 18. The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships.
    Bode W, Turk D, Karshikov A.
    Protein Sci; 1992 Apr 13; 1(4):426-71. PubMed ID: 1304349
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  • 19. Design, synthesis and biological evaluation of selective boron-containing thrombin inhibitors.
    Wienand A, Ehrhardt C, Metternich R, Tapparelli C.
    Bioorg Med Chem; 1999 Jul 13; 7(7):1295-307. PubMed ID: 10465405
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