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152 related items for PubMed ID: 7906267

  • 1. Mutation of Glu-80-->Lys results in a protein C mutant that no longer requires Ca2+ for rapid activation by the thrombin-thrombomodulin complex.
    Rezaie AR, Mather T, Sussman F, Esmon CT.
    J Biol Chem; 1994 Feb 04; 269(5):3151-4. PubMed ID: 7906267
    [Abstract] [Full Text] [Related]

  • 2. Tryptophans 231 and 234 in protein C report the Ca(2+)-dependent conformational change required for activation by the thrombin-thrombomodulin complex.
    Rezaie AR, Esmon CT.
    Biochemistry; 1995 Sep 26; 34(38):12221-6. PubMed ID: 7547963
    [Abstract] [Full Text] [Related]

  • 3. The function of calcium in protein C activation by thrombin and the thrombin-thrombomodulin complex can be distinguished by mutational analysis of protein C derivatives.
    Rezaie AR, Esmon CT.
    J Biol Chem; 1992 Dec 25; 267(36):26104-9. PubMed ID: 1334492
    [Abstract] [Full Text] [Related]

  • 4. Mutation of protease domain residues Lys37-39 in human protein C inhibits activation by the thrombomodulin-thrombin complex without affecting activation by free thrombin.
    Gerlitz B, Grinnell BW.
    J Biol Chem; 1996 Sep 13; 271(37):22285-8. PubMed ID: 8798383
    [Abstract] [Full Text] [Related]

  • 5. Glu-192----Gln substitution in thrombin mimics the catalytic switch induced by thrombomodulin.
    Le Bonniec BF, Esmon CT.
    Proc Natl Acad Sci U S A; 1991 Aug 15; 88(16):7371-5. PubMed ID: 1678522
    [Abstract] [Full Text] [Related]

  • 6. The high affinity calcium-binding site involved in protein C activation is outside the first epidermal growth factor homology domain.
    Rezaie AR, Esmon NL, Esmon CT.
    J Biol Chem; 1992 Jun 15; 267(17):11701-4. PubMed ID: 1601845
    [Abstract] [Full Text] [Related]

  • 7. Calcium-binding sites of the thrombin-thrombomodulin-protein C complex: possible implications for the effect of platelet factor 4 on the activation of vitamin K-dependent coagulation factors.
    Yang L, Rezaie AR.
    Thromb Haemost; 2007 Jun 15; 97(6):899-906. PubMed ID: 17549291
    [Abstract] [Full Text] [Related]

  • 8. Thrombomodulin allosterically modulates the activity of the anticoagulant thrombin.
    Rezaie AR, Yang L.
    Proc Natl Acad Sci U S A; 2003 Oct 14; 100(21):12051-6. PubMed ID: 14523228
    [Abstract] [Full Text] [Related]

  • 9. Asp-70-->Lys mutant of factor X lacks high affinity Ca2+ binding site yet retains function.
    Rezaie AR, Esmon CT.
    J Biol Chem; 1994 Aug 26; 269(34):21495-9. PubMed ID: 8063784
    [Abstract] [Full Text] [Related]

  • 10. Derivatives of blood coagulation factor IX contain a high affinity Ca2+-binding site that lacks gamma-carboxyglutamic acid.
    Morita T, Isaacs BS, Esmon CT, Johnson AE.
    J Biol Chem; 1984 May 10; 259(9):5698-704. PubMed ID: 6425296
    [Abstract] [Full Text] [Related]

  • 11. Probing the activation of protein C by the thrombin-thrombomodulin complex using structural analysis, site-directed mutagenesis, and computer modeling.
    Knobe KE, Berntsdotter A, Shen L, Morser J, Dahlbäck B, Villoutreix BO.
    Proteins; 1999 May 01; 35(2):218-34. PubMed ID: 10223294
    [Abstract] [Full Text] [Related]

  • 12. Further localization of binding sites for thrombin and protein C in human thrombomodulin.
    Hayashi T, Zushi M, Yamamoto S, Suzuki K.
    J Biol Chem; 1990 Nov 25; 265(33):20156-9. PubMed ID: 2173698
    [Abstract] [Full Text] [Related]

  • 13. Effects of Ca2+ binding on the protease module of factor Xa and its interaction with factor Va. Evidence for two Gla-independent Ca(2+)-binding sites in factor Xa.
    Persson E, Hogg PJ, Stenflo J.
    J Biol Chem; 1993 Oct 25; 268(30):22531-9. PubMed ID: 8226763
    [Abstract] [Full Text] [Related]

  • 14. Activation of protein C by the thrombin-thrombomodulin complex: cooperative roles of Arg-35 of thrombin and Arg-67 of protein C.
    Yang L, Manithody C, Rezaie AR.
    Proc Natl Acad Sci U S A; 2006 Jan 24; 103(4):879-84. PubMed ID: 16418283
    [Abstract] [Full Text] [Related]

  • 15. Elements of the primary structure of thrombomodulin required for efficient thrombin-activable fibrinolysis inhibitor activation.
    Wang W, Nagashima M, Schneider M, Morser J, Nesheim M.
    J Biol Chem; 2000 Jul 28; 275(30):22942-7. PubMed ID: 10801821
    [Abstract] [Full Text] [Related]

  • 16. Conversion of glutamic acid 192 to glutamine in activated protein C changes the substrate specificity and increases reactivity toward macromolecular inhibitors.
    Rezaie AR, Esmon CT.
    J Biol Chem; 1993 Sep 25; 268(27):19943-8. PubMed ID: 8104182
    [Abstract] [Full Text] [Related]

  • 17. Mutations in the fourth EGF-like domain affect thrombomodulin-induced changes in the active site of thrombin.
    Koeppe JR, Beach MA, Baerga-Ortiz A, Kerns SJ, Komives EA.
    Biochemistry; 2008 Oct 14; 47(41):10933-9. PubMed ID: 18803401
    [Abstract] [Full Text] [Related]

  • 18. Contribution of lysine 60f to S1' specificity of thrombin.
    Rezaie AR, Olson ST.
    Biochemistry; 1997 Feb 04; 36(5):1026-33. PubMed ID: 9033392
    [Abstract] [Full Text] [Related]

  • 19. Calcium-dependent activation of protein C by thrombin/thrombomudulin: role of negatively charged amino acids within the activation peptide of protein C.
    Friedrich U, Pötzsch B, Preissner KT, Müller-Berghaus G, Ehrlich H.
    Thromb Haemost; 1994 Oct 04; 72(4):567-72. PubMed ID: 7878634
    [Abstract] [Full Text] [Related]

  • 20. Calcium-binding properties of bovine factor X lacking the gamma-carboxyglutamic acid-containing region.
    Sugo T, Björk I, Holmgren A, Stenflo J.
    J Biol Chem; 1984 May 10; 259(9):5705-10. PubMed ID: 6546930
    [Abstract] [Full Text] [Related]

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