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Journal Abstract Search

132 related items for PubMed ID: 7980625

  • 1. Metabolic and radiolytic reduction of 4-alkylamino-5-nitroquinoline bioreductive drugs. Relationship to hypoxia-selective cytotoxicity.
    Siim BG, Atwell GJ, Wilson WR.
    Biochem Pharmacol; 1994 Oct 18; 48(8):1593-604. PubMed ID: 7980625
    [Abstract] [Full Text] [Related]

  • 2. Oxygen dependence of the cytotoxicity and metabolic activation of 4-alkylamino-5-nitroquinoline bioreductive drugs.
    Siim BG, Atwell GJ, Wilson WR.
    Br J Cancer; 1994 Oct 18; 70(4):596-603. PubMed ID: 7917903
    [Abstract] [Full Text] [Related]

  • 3. Hypoxia-selective antitumor agents. 15. Modification of rate of nitroreduction and extent of lysosomal uptake by polysubstitution of 4-(alkylamino)-5-nitroquinoline bioreductive drugs.
    Siim BG, Atwell GJ, Anderson RF, Wardman P, Pullen SM, Wilson WR, Denny WA.
    J Med Chem; 1997 Apr 25; 40(9):1381-90. PubMed ID: 9135035
    [Abstract] [Full Text] [Related]

  • 4. Efficient redox cycling of nitroquinoline bioreductive drugs due to aerobic nitroreduction in Chinese hamster cells.
    Siim BG, Wilson WR.
    Biochem Pharmacol; 1995 Jun 29; 50(1):75-82. PubMed ID: 7605348
    [Abstract] [Full Text] [Related]

  • 5. Does DNA targeting affect the cytotoxicity and cell uptake of basic nitroquinoline bioreductive drugs?
    Siim BG, Denny WA, Wilson WR.
    Int J Radiat Oncol Biol Phys; 1994 May 15; 29(2):311-5. PubMed ID: 8195025
    [Abstract] [Full Text] [Related]

  • 6. Hypoxia-selective antitumor agents. 13. Effects of acridine substitution on the hypoxia-selective cytotoxicity and metabolic reduction of the bis-bioreductive agent nitracrine N-oxide.
    Lee HH, Wilson WR, Ferry DM, van Zijl P, Pullen SM, Denny WA.
    J Med Chem; 1996 Jun 21; 39(13):2508-17. PubMed ID: 8691448
    [Abstract] [Full Text] [Related]

  • 7. Hypoxia-selective antitumor agents. 6. 4-(Alkylamino)nitroquinolines: a new class of hypoxia-selective cytotoxins.
    Denny WA, Atwell GJ, Roberts PB, Anderson RF, Boyd M, Lock CJ, Wilson WR.
    J Med Chem; 1992 Dec 25; 35(26):4832-41. PubMed ID: 1479583
    [Abstract] [Full Text] [Related]

  • 8. The two faces of aldehyde oxidase: Oxidative and reductive transformations of 5-nitroquinoline.
    Paragas EM, Humphreys SC, Min J, Joswig-Jones CA, Jones JP.
    Biochem Pharmacol; 2017 Dec 01; 145():210-217. PubMed ID: 28888950
    [Abstract] [Full Text] [Related]

  • 9. Enzymatic conversion of 6-nitroquinoline to the fluorophore 6-aminoquinoline selectively under hypoxic conditions.
    Rajapakse A, Linder C, Morrison RD, Sarkar U, Leigh ND, Barnes CL, Daniels JS, Gates KS.
    Chem Res Toxicol; 2013 Apr 15; 26(4):555-63. PubMed ID: 23488987
    [Abstract] [Full Text] [Related]

  • 10. Hypoxia-selective antitumor agents. 14. Synthesis and hypoxic cell cytotoxicity of regioisomers of the hypoxia-selective cytotoxin 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide.
    Palmer BD, Wilson WR, Anderson RF, Boyd M, Denny WA.
    J Med Chem; 1996 Jun 21; 39(13):2518-28. PubMed ID: 8691449
    [Abstract] [Full Text] [Related]

  • 11. 5-Nitro-4-(N,N-dimethylaminopropylamino)quinoline (5-nitraquine), a new DNA-affinic hypoxic cell radiosensitizer and bioreductive agent: comparison with nitracrine.
    Wilson WR, Siim BG, Denny WA, van Zijl PL, Taylor ML, Chambers DM, Roberts PB.
    Radiat Res; 1992 Sep 21; 131(3):257-65. PubMed ID: 1438685
    [Abstract] [Full Text] [Related]

  • 12. Bis-bioreductive agents as hypoxia-selective cytotoxins: nitracrine N-oxide.
    Wilson WR, Van Zijl P, Denny WA.
    Int J Radiat Oncol Biol Phys; 1992 Sep 21; 22(4):693-6. PubMed ID: 1544839
    [Abstract] [Full Text] [Related]

  • 13. Reductive chemistry of the novel hypoxia-selective cytotoxin 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide.
    Palmer BD, van Zijl P, Denny WA, Wilson WR.
    J Med Chem; 1995 Mar 31; 38(7):1229-41. PubMed ID: 7707325
    [Abstract] [Full Text] [Related]

  • 14. Hypoxia-selective antitumor agents. 5. Synthesis of water-soluble nitroaniline mustards with selective cytotoxicity for hypoxic mammalian cells.
    Palmer BD, Wilson WR, Cliffe S, Denny WA.
    J Med Chem; 1992 Aug 21; 35(17):3214-22. PubMed ID: 1507207
    [Abstract] [Full Text] [Related]

  • 15. Hypoxia-selective antitumor agents. 12. Nitrobenzyl quaternary salts as bioreductive prodrugs of the alkylating agent mechlorethamine.
    Tercel M, Wilson WR, Anderson RF, Denny WA.
    J Med Chem; 1996 Mar 01; 39(5):1084-94. PubMed ID: 8676343
    [Abstract] [Full Text] [Related]

  • 16. N-[2-(2-methyl-5-nitroimidazolyl)ethyl]-4-(2-nitroimidazolyl)butanamide (NSC 639862), a bisnitroimidazole with enhanced selectivity as a bioreductive drug.
    Moselen JW, Hay MP, Denny WA, Wilson WR.
    Cancer Res; 1995 Feb 01; 55(3):574-80. PubMed ID: 7834627
    [Abstract] [Full Text] [Related]

  • 17. Nitracrine N-oxides: effects of variations in the nature of the side chain N-oxide on hypoxia-selective cytotoxicity.
    Lee HH, Wilson WR, Denny WA.
    Anticancer Drug Des; 1999 Dec 01; 14(6):487-97. PubMed ID: 10834270
    [Abstract] [Full Text] [Related]

  • 18. Hypoxia-selective antitumor agents. 10. bis(nitroimidazoles) and related Bis(nitroheterocycles): development of derivatives with higher rates of metabolic activation under hypoxia and improved aqueous solubility.
    Hay MP, Lee HH, Wilson WR, Roberts PB, Denny WA.
    J Med Chem; 1995 May 26; 38(11):1928-41. PubMed ID: 7783125
    [Abstract] [Full Text] [Related]

  • 19. Hypoxia-selective antitumor agents. 7. Metal complexes of aliphatic mustards as a new class of hypoxia-selective cytotoxins. Synthesis and evaluation of cobalt(III) complexes of bidentate mustards.
    Ware DC, Palmer BD, Wilson WR, Denny WA.
    J Med Chem; 1993 Jun 25; 36(13):1839-46. PubMed ID: 8515422
    [Abstract] [Full Text] [Related]

  • 20. Nitro analogues of chlorambucil as potential hypoxia-selective anti-tumour drugs.
    Palmer BD, Wilson WR, Denny WA.
    Anticancer Drug Des; 1990 Nov 25; 5(4):337-49. PubMed ID: 2291774
    [Abstract] [Full Text] [Related]

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