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150 related items for PubMed ID: 7981057

  • 1. Determinants of trimetrexate lethality in human colon cancer cells.
    Grem JL, Voeller DM, Geoffroy F, Horak E, Johnston PG, Allegra CJ.
    Br J Cancer; 1994 Dec; 70(6):1075-84. PubMed ID: 7981057
    [Abstract] [Full Text] [Related]

  • 2. Expression of variant dihydrofolate reductase with decreased binding affinity to antifolates in MOLT-3 human leukemia cell lines resistant to trimetrexate.
    Miyachi H, Takemura Y, Kobayashi H, Ando Y.
    Cancer Lett; 1995 Jan 06; 88(1):93-9. PubMed ID: 7850779
    [Abstract] [Full Text] [Related]

  • 3. Determinants of sensitivity to 1-beta-D-arabinofuranosylcytosine in HCT 116 and NCI-H630 human colon carcinoma cells.
    Grem JL, Geoffroy F, Politi PM, Cuddy DP, Ross DD, Nguyen D, Steinberg SM, Allegra CJ.
    Mol Pharmacol; 1995 Aug 06; 48(2):305-15. PubMed ID: 7651364
    [Abstract] [Full Text] [Related]

  • 4. Cytotoxicity of trimetrexate against antifolate-resistant human T-cell leukemia cell lines developed in oxidized or reduced folate.
    Miyachi H, Takemura Y, Kobayashi H, Ando Y.
    Jpn J Cancer Res; 1997 Sep 06; 88(9):900-6. PubMed ID: 9369939
    [Abstract] [Full Text] [Related]

  • 5. Structures of dihydrofolate reductase-thymidylate synthase of Trypanosoma cruzi in the folate-free state and in complex with two antifolate drugs, trimetrexate and methotrexate.
    Senkovich O, Schormann N, Chattopadhyay D.
    Acta Crystallogr D Biol Crystallogr; 2009 Jul 06; 65(Pt 7):704-16. PubMed ID: 19564691
    [Abstract] [Full Text] [Related]

  • 6. Determinants of cytotoxicity with prolonged exposure to fluorouracil in human colon cancer cells.
    Ren Q, Van Groeningen CJ, Hardcastle A, Aherne GW, Geoffroy F, Allegra CJ, Johnston PG, Grem JL.
    Oncol Res; 1997 Jul 06; 9(2):77-88. PubMed ID: 9167189
    [Abstract] [Full Text] [Related]

  • 7. Enzyme studies of methotrexate-resistant human leukemic cell (K562) subclones.
    Koizumi S, Allegra CJ.
    Leuk Res; 1992 Jul 06; 16(6-7):565-9. PubMed ID: 1378915
    [Abstract] [Full Text] [Related]

  • 8. Thymidine and hypoxanthine protection patterns of the folic acid-enhanced synergies for combinations of trimetrexate plus a polyglutamylatable inhibitor of purine or thymidylate synthesis against human ileocecal HCT-8 cells.
    Faessel HM, Slocum HK, Rustum YM, Greco WR.
    Int J Oncol; 2003 Aug 06; 23(2):401-9. PubMed ID: 12851689
    [Abstract] [Full Text] [Related]

  • 9. Biochemical studies on PT523, a potent nonpolyglutamatable antifolate, in cultured cells.
    Rhee MS, Galivan J, Wright JE, Rosowsky A.
    Mol Pharmacol; 1994 Apr 06; 45(4):783-91. PubMed ID: 7514264
    [Abstract] [Full Text] [Related]

  • 10. Folic acid-enhanced synergy for the combination of trimetrexate plus the glycinamide ribonucleotide formyltransferase inhibitor 4-[2-(2-amino-4-oxo-4,6,7,8-tetrahydro-3H-pyrimidino[5,4,6][1,4]thiazin -6-yl)-(S)-ethyl]-2,5-thienoylamino-L-glutamic acid (AG2034): comparison across sensitive and resistant human tumor cell lines.
    Faessel HM, Slocum HK, Rustum YM, Greco WR.
    Biochem Pharmacol; 1999 Mar 01; 57(5):567-77. PubMed ID: 9952321
    [Abstract] [Full Text] [Related]

  • 11. N10-propargyl-5,8-dideazafolic acid (CB3717): inhibitory effects on human leukemia cell lines resistant to methotrexate or trimetrexate.
    Takemura Y, Ohnuma T.
    Mt Sinai J Med; 1992 Oct 01; 59(5):419-24. PubMed ID: 1435841
    [Abstract] [Full Text] [Related]

  • 12. Expression of dihydrofolate reductase and multidrug resistance genes in trimetrexate-resistant human leukemia cell lines.
    Li XK, Kobayashi H, Holland JF, Ohnuma T.
    Leuk Res; 1993 Jun 01; 17(6):483-90. PubMed ID: 8099375
    [Abstract] [Full Text] [Related]

  • 13. Conformational analysis of the lipophilic antifolate trimetrexate.
    Hoffman VA, Welsh WJ.
    Cancer Biochem Biophys; 1995 Jan 01; 14(4):281-95. PubMed ID: 7767902
    [Abstract] [Full Text] [Related]

  • 14. Rate and extent of interconversion of tetrahydrofolate cofactors to dihydrofolate after cessation of dihydrofolate reductase activity in stationary versus log phase L1210 leukemia cells.
    Trent DF, Seither RL, Goldman ID.
    J Biol Chem; 1991 Mar 25; 266(9):5445-9. PubMed ID: 1825999
    [Abstract] [Full Text] [Related]

  • 15. Enhanced cytotoxicity with interleukin-1 alpha and 5-fluorouracil in HCT116 colon cancer cells.
    Geoffroy FJ, Allegra CJ, Sinha B, Grem JL.
    Oncol Res; 1994 Mar 25; 6(12):581-91. PubMed ID: 7787251
    [Abstract] [Full Text] [Related]

  • 16. Biological activity and intracellular metabolism of ZD1694 in human leukemia cell lines with different resistance mechanisms to antifolate drugs.
    Takemura Y, Kobayashi H, Miyachi H, Gibson W, Kimbell R, Jackman AL.
    Jpn J Cancer Res; 1996 Jul 25; 87(7):773-80. PubMed ID: 8698629
    [Abstract] [Full Text] [Related]

  • 17. Metabolism and RNA incorporation of cyclopentenyl cytosine in human colorectal cancer cells.
    Yee LK, Allegra CJ, Trepel JB, Grem JL.
    Biochem Pharmacol; 1992 Apr 01; 43(7):1587-99. PubMed ID: 1567480
    [Abstract] [Full Text] [Related]

  • 18. Effects of methotrexate and of the "nonclassical" folate antagonist trimetrexate on human leukemia cells.
    Rodenhuis S, McGuire JJ, Sawicki WL, Bertino JR.
    Leukemia; 1987 Feb 01; 1(2):116-20. PubMed ID: 2959824
    [Abstract] [Full Text] [Related]

  • 19. Interaction of gamma interferon and 5-fluorouracil in the H630 human colon carcinoma cell line.
    Chu E, Zinn S, Boarman D, Allegra CJ.
    Cancer Res; 1990 Sep 15; 50(18):5834-40. PubMed ID: 1697502
    [Abstract] [Full Text] [Related]

  • 20. Multidrug resistance in a human leukemic cell line selected for resistance to trimetrexate.
    Arkin H, Ohnuma T, Kamen BA, Holland JF, Vallabhajosula S.
    Cancer Res; 1989 Dec 01; 49(23):6556-61. PubMed ID: 2573416
    [Abstract] [Full Text] [Related]

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