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Journal Abstract Search

218 related items for PubMed ID: 7981204

  • 1. Design of potent bivalent thrombin inhibitors based on hirudin sequence: incorporation of nonsubstrate-type active site inhibitors.
    Tsuda Y, Cygler M, Gibbs BF, Pedyczak A, Féthière J, Yue SY, Konishi Y.
    Biochemistry; 1994 Dec 06; 33(48):14443-51. PubMed ID: 7981204
    [Abstract] [Full Text] [Related]

  • 2. Design of P1' and P3' residues of trivalent thrombin inhibitors and their crystal structures.
    Slon-Usakiewicz JJ, Sivaraman J, Li Y, Cygler M, Konishi Y.
    Biochemistry; 2000 Mar 07; 39(9):2384-91. PubMed ID: 10694407
    [Abstract] [Full Text] [Related]

  • 3. Crystal structure of two new bifunctional nonsubstrate type thrombin inhibitors complexed with human alpha-thrombin.
    Féthière J, Tsuda Y, Coulombe R, Konishi Y, Cygler M.
    Protein Sci; 1996 Jun 07; 5(6):1174-83. PubMed ID: 8762149
    [Abstract] [Full Text] [Related]

  • 4. Interactions of hirudin-based inhibitor with thrombin: critical role of the IleH59 side chain of the inhibitor.
    Tsuda Y, Szewczuk Z, Wang J, Yue SY, Purisima E, Konishi Y.
    Biochemistry; 1995 Jul 11; 34(27):8708-14. PubMed ID: 7612610
    [Abstract] [Full Text] [Related]

  • 5. Crystal structure of the complex of human alpha-thrombin and nonhydrolyzable bifunctional inhibitors, hirutonin-2 and hirutonin-6.
    Zdanov A, Wu S, DiMaio J, Konishi Y, Li Y, Wu X, Edwards BF, Martin PD, Cygler M.
    Proteins; 1993 Nov 11; 17(3):252-65. PubMed ID: 8272424
    [Abstract] [Full Text] [Related]

  • 6. Bifunctional peptide boronate inhibitors of thrombin: crystallographic analysis of inhibition enhanced by linkage to an exosite 1 binding peptide.
    Skordalakes E, Elgendy S, Goodwin CA, Green D, Scully MF, Kakkar VV, Freyssinet JM, Dodson G, Deadman JJ.
    Biochemistry; 1998 Oct 13; 37(41):14420-7. PubMed ID: 9772168
    [Abstract] [Full Text] [Related]

  • 7. A new class of potent thrombin inhibitors that incorporates a scissile pseudopeptide bond.
    DiMaio J, Ni F, Gibbs B, Konishi Y.
    FEBS Lett; 1991 Apr 22; 282(1):47-52. PubMed ID: 2026264
    [Abstract] [Full Text] [Related]

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  • 9. Design of a linker for trivalent thrombin inhibitors: interaction of the main chain of the linker with thrombin.
    Szewczuk Z, Gibbs BF, Yue SY, Purisima E, Zdanov A, Cygler M, Konishi Y.
    Biochemistry; 1993 Apr 06; 32(13):3396-404. PubMed ID: 8461303
    [Abstract] [Full Text] [Related]

  • 10. Nonpolar interactions of thrombin S' subsites with its bivalent inhibitor: methyl scan of the inhibitor linker.
    Slon-Usakiewicz JJ, Purisima E, Tsuda Y, Sulea T, Pedyczak A, Féthière J, Cygler M, Konishi Y.
    Biochemistry; 1997 Nov 04; 36(44):13494-502. PubMed ID: 9354617
    [Abstract] [Full Text] [Related]

  • 11. Hirunorms are true hirudin mimetics. The crystal structure of human alpha-thrombin-hirunorm V complex.
    De Simone G, Lombardi A, Galdiero S, Nastri F, Della Morte R, Staiano N, Pedone C, Bolognesi M, Pavone V.
    Protein Sci; 1998 Feb 04; 7(2):243-53. PubMed ID: 9521099
    [Abstract] [Full Text] [Related]

  • 12. Potent bivalent thrombin inhibitors: replacement of the scissile peptide bond at P(1)-P(1)' with arginyl ketomethylene isosteres.
    Steinmetzer T, Zhu BY, Konishi Y.
    J Med Chem; 1999 Aug 12; 42(16):3109-15. PubMed ID: 10447955
    [Abstract] [Full Text] [Related]

  • 13. Rational design and selection of bivalent peptide ligands of thrombin incorporating P4-P1 tetrapeptide sequences: from good substrates to potent inhibitors.
    Su Z, Vinogradova A, Koutychenko A, Tolkatchev D, Ni F.
    Protein Eng Des Sel; 2004 Aug 12; 17(8):647-57. PubMed ID: 15358856
    [Abstract] [Full Text] [Related]

  • 14. Hirulog peptides with scissile bond replacements resistant to thrombin cleavage.
    Kline T, Hammond C, Bourdon P, Maraganore JM.
    Biochem Biophys Res Commun; 1991 Jun 28; 177(3):1049-55. PubMed ID: 2059196
    [Abstract] [Full Text] [Related]

  • 15. Changes in interactions in complexes of hirudin derivatives and human alpha-thrombin due to different crystal forms.
    Priestle JP, Rahuel J, Rink H, Tones M, Grütter MG.
    Protein Sci; 1993 Oct 28; 2(10):1630-42. PubMed ID: 8251938
    [Abstract] [Full Text] [Related]

  • 16. Rational design of true hirudin mimetics: synthesis and characterization of multisite-directed alpha-thrombin inhibitors.
    Lombardi A, Nastri F, Della Morte R, Rossi A, De Rosa A, Staiano N, Pedone C, Pavone V.
    J Med Chem; 1996 May 10; 39(10):2008-17. PubMed ID: 8642559
    [Abstract] [Full Text] [Related]

  • 17. Structure of the hirulog 3-thrombin complex and nature of the S' subsites of substrates and inhibitors.
    Qiu X, Padmanabhan KP, Carperos VE, Tulinsky A, Kline T, Maraganore JM, Fenton JW.
    Biochemistry; 1992 Dec 01; 31(47):11689-97. PubMed ID: 1445905
    [Abstract] [Full Text] [Related]

  • 18. Rational design of hirulog-type inhibitors of thrombin.
    Egner U, Hoyer GA, Schleuning WD.
    J Comput Aided Mol Des; 1994 Oct 01; 8(5):479-90. PubMed ID: 7876896
    [Abstract] [Full Text] [Related]

  • 19. Crystal structure of a peptidyl pyridinium methyl ketone inhibitor with thrombin.
    Rehse PH, Steinmetzer T, Li Y, Konishi Y, Cygler M.
    Biochemistry; 1995 Sep 12; 34(36):11537-44. PubMed ID: 7547884
    [Abstract] [Full Text] [Related]

  • 20. Incorporation of noncoded amino acids into the N-terminal domain 1-47 of hirudin yields a highly potent and selective thrombin inhibitor.
    De Filippis V, Russo I, Vindigni A, Di Cera E, Salmaso S, Fontana A.
    Protein Sci; 1999 Oct 12; 8(10):2213-7. PubMed ID: 10548068
    [Abstract] [Full Text] [Related]

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