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Journal Abstract Search

131 related items for PubMed ID: 7981224

  • 1. Mammalian DNA polymerases alpha, beta, gamma, delta, and epsilon incorporate fialuridine (FIAU) monophosphate into DNA and are inhibited competitively by FIAU Triphosphate.
    Lewis W, Meyer RR, Simpson JF, Colacino JM, Perrino FW.
    Biochemistry; 1994 Dec 06; 33(48):14620-4. PubMed ID: 7981224
    [Abstract] [Full Text] [Related]

  • 2. Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts.
    Lewis W, Levine ES, Griniuviene B, Tankersley KO, Colacino JM, Sommadossi JP, Watanabe KA, Perrino FW.
    Proc Natl Acad Sci U S A; 1996 Apr 16; 93(8):3592-7. PubMed ID: 8622980
    [Abstract] [Full Text] [Related]

  • 3. Kinetic analysis of the interaction between the diphosphate of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, ddCTP, AZTTP, and FIAUTP with human DNA polymerases beta and gamma.
    Cherrington JM, Allen SJ, McKee BH, Chen MS.
    Biochem Pharmacol; 1994 Nov 16; 48(10):1986-8. PubMed ID: 7986213
    [Abstract] [Full Text] [Related]

  • 4. Priming of duck hepatitis B virus reverse transcription in vitro: premature termination of primer DNA induced by the 5'-triphosphate of fialuridine.
    Staschke KA, Colacino JM.
    J Virol; 1994 Dec 16; 68(12):8265-9. PubMed ID: 7525986
    [Abstract] [Full Text] [Related]

  • 5. Interactions of azidothymidine triphosphate with the cellular DNA polymerases alpha, delta, and epsilon and with DNA primase.
    Nickel W, Austermann S, Bialek G, Grosse F.
    J Biol Chem; 1992 Jan 15; 267(2):848-54. PubMed ID: 1730673
    [Abstract] [Full Text] [Related]

  • 6. Stereospecificity of human DNA polymerases alpha, beta, gamma, delta and epsilon, HIV-reverse transcriptase, HSV-1 DNA polymerase, calf thymus terminal transferase and Escherichia coli DNA polymerase I in recognizing D- and L-thymidine 5'-triphosphate as substrate.
    Focher F, Maga G, Bendiscioli A, Capobianco M, Colonna F, Garbesi A, Spadari S.
    Nucleic Acids Res; 1995 Aug 11; 23(15):2840-7. PubMed ID: 7544886
    [Abstract] [Full Text] [Related]

  • 7. Fialuridine is phosphorylated and inhibits DNA synthesis in isolated rat hepatic mitochondria.
    Horn DM, Neeb LA, Colacino JM, Richardson FC.
    Antiviral Res; 1997 Mar 11; 34(1):71-4. PubMed ID: 9107387
    [Abstract] [Full Text] [Related]

  • 8. Mechanism of selective inhibition of human cytomegalovirus replication by 1-beta-D-arabinofuranosyl-5-fluorouracil.
    Suzuki S, Saneyoshi M, Nakayama C, Nishiyama Y, Yoshida S.
    Antimicrob Agents Chemother; 1985 Aug 11; 28(2):326-30. PubMed ID: 3010844
    [Abstract] [Full Text] [Related]

  • 9. Toxicity, metabolism, DNA incorporation with lack of repair, and lactate production for 1-(2'-fluoro-2'-deoxy-beta-D-arabinofuranosyl)-5-iodouracil in U-937 and MOLT-4 cells.
    Klecker RW, Katki AG, Collins JM.
    Mol Pharmacol; 1994 Dec 11; 46(6):1204-9. PubMed ID: 7808443
    [Abstract] [Full Text] [Related]

  • 10. Chiral discrimination of enantiomeric 2'-deoxythymidine 5'-triphosphate by HIV-1 reverse transcriptase and eukaryotic DNA polymerases.
    Yamaguchi T, Iwanami N, Shudo K, Saneyoshi M.
    Biochem Biophys Res Commun; 1994 Apr 29; 200(2):1023-7. PubMed ID: 7513992
    [Abstract] [Full Text] [Related]

  • 11. Archaebacterial DNA polymerases tightly bind uracil-containing DNA.
    Lasken RS, Schuster DM, Rashtchian A.
    J Biol Chem; 1996 Jul 26; 271(30):17692-6. PubMed ID: 8663453
    [Abstract] [Full Text] [Related]

  • 12. Purification and characterization of porcine liver DNA polymerase gamma: utilization of dUTP and dTTP during in vitro DNA synthesis.
    Mosbaugh DW.
    Nucleic Acids Res; 1988 Jun 24; 16(12):5645-59. PubMed ID: 3387242
    [Abstract] [Full Text] [Related]

  • 13. Mechanisms for the anti-hepatitis B virus activity and mitochondrial toxicity of fialuridine (FIAU).
    Colacino JM.
    Antiviral Res; 1996 Mar 24; 29(2-3):125-39. PubMed ID: 8739593
    [Abstract] [Full Text] [Related]

  • 14. Polymerization of 2'-fluoro- and 2'-O-methyl-dNTPs by human DNA polymerase alpha, polymerase gamma, and primase.
    Richardson FC, Kuchta RD, Mazurkiewicz A, Richardson KA.
    Biochem Pharmacol; 2000 May 01; 59(9):1045-52. PubMed ID: 10704933
    [Abstract] [Full Text] [Related]

  • 15. Depletion of mitochondrial DNA, destruction of mitochondria, and accumulation of lipid droplets result from fialuridine treatment in woodchucks (Marmota monax).
    Lewis W, Griniuviene B, Tankersley KO, Levine ES, Montione R, Engelman L, de Courten-Myers G, Ascenzi MA, Hornbuckle WE, Gerin JL, Tennant BC.
    Lab Invest; 1997 Jan 01; 76(1):77-87. PubMed ID: 9010451
    [Abstract] [Full Text] [Related]

  • 16. Differential effects of the incorporation of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodouracil (FIAU) on the binding of the transcription factors, AP-1 and TFIID, to their cognate target DNA sequences.
    Staschke KA, Richardson KK, Mabry TE, Baxter AJ, Scheuring JC, Huffman DM, Smith WC, Richardson FC, Colacino JM.
    Nucleic Acids Res; 1996 Nov 01; 24(21):4111-6. PubMed ID: 8932359
    [Abstract] [Full Text] [Related]

  • 17. Human cytomegalovirus-induced DNA polymerase and its interaction with the triphosphates of 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-methyluracil, -5-iodocytosine, and -5-methylcytosine.
    Mar EC, Chiou JF, Cheng YC, Huang ES.
    J Virol; 1985 Dec 01; 56(3):846-51. PubMed ID: 2999440
    [Abstract] [Full Text] [Related]

  • 18. The in vitro anti-hepatitis B virus activity of FIAU [1-(2'-deoxy-2'-fluoro-1-beta-D-arabinofuranosyl-5-iodo)uracil] is selective, reversible, and determined, at least in part, by the host cell.
    Staschke KA, Colacino JM, Mabry TE, Jones CD.
    Antiviral Res; 1994 Jan 01; 23(1):45-61. PubMed ID: 8141592
    [Abstract] [Full Text] [Related]

  • 19. Utilization in vitro of deoxyuridine triphosphate in DNA synthesis by DNA polymerases alpha and beta from calf thymus.
    Yoshida S, Masaki S.
    Biochim Biophys Acta; 1979 Feb 27; 561(2):396-402. PubMed ID: 427163
    [Abstract] [Full Text] [Related]

  • 20. Phosphorylation of the anti-hepatitis B nucleoside analog 1-(2'-deoxy-2'-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil (FIAU) by human cytosolic and mitochondrial thymidine kinase and implications for cytotoxicity.
    Wang J, Eriksson S.
    Antimicrob Agents Chemother; 1996 Jun 27; 40(6):1555-7. PubMed ID: 8726039
    [Abstract] [Full Text] [Related]

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