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Journal Abstract Search

123 related items for PubMed ID: 7981423

  • 1. Metabolic activation and immunochemical localization of liver protein adducts of the nonsteroidal anti-inflammatory drug diclofenac.
    Hargus SJ, Amouzedeh HR, Pumford NR, Myers TG, McCoy SC, Pohl LR.
    Chem Res Toxicol; 1994; 7(4):575-82. PubMed ID: 7981423
    [Abstract] [Full Text] [Related]

  • 2. Selective protein adducts to membrane proteins in cultured rat hepatocytes exposed to diclofenac: radiochemical and immunochemical analysis.
    Kretz-Rommel A, Boelsterli UA.
    Mol Pharmacol; 1994 Feb; 45(2):237-44. PubMed ID: 8114673
    [Abstract] [Full Text] [Related]

  • 3. Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites.
    Tang W, Stearns RA, Bandiera SM, Zhang Y, Raab C, Braun MP, Dean DC, Pang J, Leung KH, Doss GA, Strauss JR, Kwei GY, Rushmore TH, Chiu SH, Baillie TA.
    Drug Metab Dispos; 1999 Mar; 27(3):365-72. PubMed ID: 10064567
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  • 4. Immunochemical identification of mouse hepatic protein adducts derived from the nonsteroidal anti-inflammatory drugs diclofenac, sulindac, and ibuprofen.
    Wade LT, Kenna JG, Caldwell J.
    Chem Res Toxicol; 1997 May; 10(5):546-55. PubMed ID: 9168252
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  • 5. Mechanism of covalent adduct formation of diclofenac to rat hepatic microsomal proteins. Retention of the glucuronic acid moiety in the adduct.
    Kretz-Rommel A, Boelsterli UA.
    Drug Metab Dispos; 1994 May; 22(6):956-61. PubMed ID: 7895615
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  • 6. Immunochemical detection of protein adducts in cultured human hepatocytes exposed to diclofenac.
    Gil ML, Ramirez MC, Terencio MC, Castell JV.
    Biochim Biophys Acta; 1995 Dec 12; 1272(3):140-6. PubMed ID: 8541344
    [Abstract] [Full Text] [Related]

  • 7. Cytochrome P4502C11 is a target of diclofenac covalent binding in rats.
    Shen S, Hargus SJ, Martin BM, Pohl LR.
    Chem Res Toxicol; 1997 Apr 12; 10(4):420-3. PubMed ID: 9114979
    [Abstract] [Full Text] [Related]

  • 8. The metabolism of diclofenac--enzymology and toxicology perspectives.
    Tang W.
    Curr Drug Metab; 2003 Aug 12; 4(4):319-29. PubMed ID: 12871048
    [Abstract] [Full Text] [Related]

  • 9. Immunochemical detection of liver protein adducts of the nonsteroidal antiinflammatory drug diclofenac.
    Pumford NR, Myers TG, Davila JC, Highet RJ, Pohl LR.
    Chem Res Toxicol; 1993 Aug 12; 6(2):147-50. PubMed ID: 8477004
    [Abstract] [Full Text] [Related]

  • 10. Increase in covalent binding of 5-hydroxydiclofenac to hepatic tissues in rats co-treated with lipopolysaccharide and diclofenac: involvement in the onset of diclofenac-induced idiosyncratic hepatotoxicity.
    Kishida T, Onozato T, Kanazawa T, Tanaka S, Kuroda J.
    J Toxicol Sci; 2012 Aug 12; 37(6):1143-56. PubMed ID: 23208430
    [Abstract] [Full Text] [Related]

  • 11. Selective protein adduct formation of diclofenac glucuronide is critically dependent on the rat canalicular conjugate export pump (Mrp2).
    Seitz S, Kretz-Rommel A, Oude Elferink RP, Boelsterli UA.
    Chem Res Toxicol; 1998 May 12; 11(5):513-9. PubMed ID: 9585482
    [Abstract] [Full Text] [Related]

  • 12. Diclofenac covalent protein binding is dependent on acyl glucuronide formation and is inversely related to P450-mediated acute cell injury in cultured rat hepatocytes.
    Kretz-Rommel A, Boelsterli UA.
    Toxicol Appl Pharmacol; 1993 May 12; 120(1):155-61. PubMed ID: 8511777
    [Abstract] [Full Text] [Related]

  • 13. In vivo perturbation of rat hepatocyte canalicular membrane function by diclofenac.
    Sallustio BC, Holbrook FL.
    Drug Metab Dispos; 2001 Dec 12; 29(12):1535-8. PubMed ID: 11717171
    [Abstract] [Full Text] [Related]

  • 14. Metabolic activation of diclofenac by human cytochrome P450 3A4: role of 5-hydroxydiclofenac.
    Shen S, Marchick MR, Davis MR, Doss GA, Pohl LR.
    Chem Res Toxicol; 1999 Feb 12; 12(2):214-22. PubMed ID: 10027801
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  • 18. Involvement of Reactive Metabolites of Diclofenac in Cytotoxicity in Sandwich-Cultured Rat Hepatocytes.
    Kawase A, Hashimoto R, Shibata M, Shimada H, Iwaki M.
    Int J Toxicol; 2017 Feb 12; 36(3):260-267. PubMed ID: 28553770
    [Abstract] [Full Text] [Related]

  • 19. Immunochemical detection and identification of protein adducts of diclofenac in the small intestine of rats: possible role in allergic reactions.
    Ware JA, Graf ML, Martin BM, Lustberg LR, Pohl LR.
    Chem Res Toxicol; 1998 Mar 12; 11(3):164-71. PubMed ID: 9544613
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