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121 related items for PubMed ID: 7983032

  • 1. Metabolism of the "Swedish" amyloid precursor protein variant in Madin-Darby canine kidney cells.
    Lo AC, Haass C, Wagner SL, Teplow DB, Sisodia SS.
    J Biol Chem; 1994 Dec 09; 269(49):30966-73. PubMed ID: 7983032
    [Abstract] [Full Text] [Related]

  • 2. Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus.
    Thinakaran G, Teplow DB, Siman R, Greenberg B, Sisodia SS.
    J Biol Chem; 1996 Apr 19; 271(16):9390-7. PubMed ID: 8621605
    [Abstract] [Full Text] [Related]

  • 3. Basolateral secretion of amyloid precursor protein in Madin-Darby canine kidney cells is disturbed by alterations of intracellular pH and by introducing a mutation associated with familial Alzheimer's disease.
    De Strooper B, Craessaerts K, Dewachter I, Moechars D, Greenberg B, Van Leuven F, Van den Berghe H.
    J Biol Chem; 1995 Feb 24; 270(8):4058-65. PubMed ID: 7876155
    [Abstract] [Full Text] [Related]

  • 4. An alternative secretase cleavage produces soluble Alzheimer amyloid precursor protein containing a potentially amyloidogenic sequence.
    Anderson JP, Chen Y, Kim KS, Robakis NK.
    J Neurochem; 1992 Dec 24; 59(6):2328-31. PubMed ID: 1431910
    [Abstract] [Full Text] [Related]

  • 5. The Alzheimer beta-amyloid protein precursor/protease nexin-II is cleaved by secretase in a trans-Golgi secretory compartment in human neuroglioma cells.
    Kuentzel SL, Ali SM, Altman RA, Greenberg BD, Raub TJ.
    Biochem J; 1993 Oct 15; 295 ( Pt 2)(Pt 2):367-78. PubMed ID: 8240235
    [Abstract] [Full Text] [Related]

  • 6. gamma-secretase cleavage is distinct from endoplasmic reticulum degradation of the transmembrane domain of the amyloid precursor protein.
    Bunnell WL, Pham HV, Glabe CG.
    J Biol Chem; 1998 Nov 27; 273(48):31947-55. PubMed ID: 9822665
    [Abstract] [Full Text] [Related]

  • 7. Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals.
    Haass C, Koo EH, Capell A, Teplow DB, Selkoe DJ.
    J Cell Biol; 1995 Feb 27; 128(4):537-47. PubMed ID: 7860629
    [Abstract] [Full Text] [Related]

  • 8. Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease.
    Lammich S, Kojro E, Postina R, Gilbert S, Pfeiffer R, Jasionowski M, Haass C, Fahrenholz F.
    Proc Natl Acad Sci U S A; 1999 Mar 30; 96(7):3922-7. PubMed ID: 10097139
    [Abstract] [Full Text] [Related]

  • 9. Differential effects of a Rab6 mutant on secretory versus amyloidogenic processing of Alzheimer's beta-amyloid precursor protein.
    McConlogue L, Castellano F, deWit C, Schenk D, Maltese WA.
    J Biol Chem; 1996 Jan 19; 271(3):1343-8. PubMed ID: 8576122
    [Abstract] [Full Text] [Related]

  • 10. Polarized secretion of beta-amyloid precursor protein and amyloid beta-peptide in MDCK cells.
    Haass C, Koo EH, Teplow DB, Selkoe DJ.
    Proc Natl Acad Sci U S A; 1994 Feb 15; 91(4):1564-8. PubMed ID: 8108445
    [Abstract] [Full Text] [Related]

  • 11. Exchanging the extracellular domain of amyloid precursor protein for horseradish peroxidase does not interfere with alpha-secretase cleavage of the beta-amyloid region, but randomizes secretion in Madin-Darby canine kidney cells.
    De Strooper B, Craessaerts K, Van Leuven F, Van Den Berghe H.
    J Biol Chem; 1995 Dec 22; 270(51):30310-4. PubMed ID: 8530453
    [Abstract] [Full Text] [Related]

  • 12. Release of amino-terminal fragments from amyloid precursor protein reporter and mutated derivatives in cultured cells.
    Sahasrabudhe SR, Spruyt MA, Muenkel HA, Blume AJ, Vitek MP, Jacobsen JS.
    J Biol Chem; 1992 Dec 15; 267(35):25602-8. PubMed ID: 1281162
    [Abstract] [Full Text] [Related]

  • 13. The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway.
    Haass C, Lemere CA, Capell A, Citron M, Seubert P, Schenk D, Lannfelt L, Selkoe DJ.
    Nat Med; 1995 Dec 15; 1(12):1291-6. PubMed ID: 7489411
    [Abstract] [Full Text] [Related]

  • 14. Metabolites of the beta-amyloid precursor protein generated by beta-secretase localise to the trans-Golgi network and late endosome in 293 cells.
    Stephens DJ, Austen BM.
    J Neurosci Res; 1996 Oct 15; 46(2):211-25. PubMed ID: 8915898
    [Abstract] [Full Text] [Related]

  • 15. Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain.
    Furukawa K, Sopher BL, Rydel RE, Begley JG, Pham DG, Martin GM, Fox M, Mattson MP.
    J Neurochem; 1996 Nov 15; 67(5):1882-96. PubMed ID: 8863493
    [Abstract] [Full Text] [Related]

  • 16. Evaluation of cathepsins D and G and EC 3.4.24.15 as candidate beta-secretase proteases using peptide and amyloid precursor protein substrates.
    Brown AM, Tummolo DM, Spruyt MA, Jacobsen JS, Sonnenberg-Reines J.
    J Neurochem; 1996 Jun 15; 66(6):2436-45. PubMed ID: 8632167
    [Abstract] [Full Text] [Related]

  • 17. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
    Deng Y, Wang Z, Wang R, Zhang X, Zhang S, Wu Y, Staufenbiel M, Cai F, Song W.
    Eur J Neurosci; 2013 Jun 15; 37(12):1962-9. PubMed ID: 23773065
    [Abstract] [Full Text] [Related]

  • 18. Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network.
    Skovronsky DM, Moore DB, Milla ME, Doms RW, Lee VM.
    J Biol Chem; 2000 Jan 28; 275(4):2568-75. PubMed ID: 10644715
    [Abstract] [Full Text] [Related]

  • 19. Cleavage of Alzheimer's amyloid precursor protein (APP) by secretases occurs after O-glycosylation of APP in the protein secretory pathway. Identification of intracellular compartments in which APP cleavage occurs without using toxic agents that interfere with protein metabolism.
    Tomita S, Kirino Y, Suzuki T.
    J Biol Chem; 1998 Mar 13; 273(11):6277-84. PubMed ID: 9497354
    [Abstract] [Full Text] [Related]

  • 20. Purification and cloning of amyloid precursor protein beta-secretase from human brain.
    Sinha S, Anderson JP, Barbour R, Basi GS, Caccavello R, Davis D, Doan M, Dovey HF, Frigon N, Hong J, Jacobson-Croak K, Jewett N, Keim P, Knops J, Lieberburg I, Power M, Tan H, Tatsuno G, Tung J, Schenk D, Seubert P, Suomensaari SM, Wang S, Walker D, Zhao J, McConlogue L, John V.
    Nature; 1999 Dec 02; 402(6761):537-40. PubMed ID: 10591214
    [Abstract] [Full Text] [Related]


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