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142 related items for PubMed ID: 7983237

  • 1. Pharmacokinetics and safety of NM441, a new quinolone, in healthy male volunteers.
    Nakashima M, Uematsu T, Kosuge K, Okuyama Y, Morino A, Ozaki M, Takebe Y.
    J Clin Pharmacol; 1994 Sep; 34(9):930-7. PubMed ID: 7983237
    [Abstract] [Full Text] [Related]

  • 2. Pharmacokinetics of prulifloxacin. 1st communication: absorption, distribution and excretion in rats, dogs and monkeys after a single administration.
    Okuyama Y, Momota K, Morino A.
    Arzneimittelforschung; 1997 Mar; 47(3):276-84. PubMed ID: 9105546
    [Abstract] [Full Text] [Related]

  • 3. In vivo antibacterial activity of a prodrug of NM394, a thiazetoquinoline carboxylic acid derivative.
    Ozaki M, Tomii Y, Matsuda M, Segawa J, Kitano M, Kise M, Nishino T.
    Chemotherapy; 1998 Mar; 44(1):21-30. PubMed ID: 9444405
    [Abstract] [Full Text] [Related]

  • 4. Pharmacokinetics of prulifloxacin. 2nd communication: pharmacokinetics and effect on hepatic drug-metabolizing enzyme activities after repeated administration and transfer into fetus and milk after a single administration in rats.
    Okuyama Y, Momota K, Morino A.
    Arzneimittelforschung; 1997 Mar; 47(3):285-92. PubMed ID: 9105547
    [Abstract] [Full Text] [Related]

  • 5. Pharmacokinetics of prulifloxacin. 3rd communication: metabolism in rats, dogs and monkeys.
    Okuyama Y, Morino A.
    Arzneimittelforschung; 1997 Mar; 47(3):293-8. PubMed ID: 9105548
    [Abstract] [Full Text] [Related]

  • 6. In vivo evaluation of NM441, a new thiazeto-quinoline derivative.
    Ozaki M, Matsuda M, Tomii Y, Kimura K, Segawa J, Kitano M, Kise M, Shibata K, Otsuki M, Nishino T.
    Antimicrob Agents Chemother; 1991 Dec; 35(12):2496-9. PubMed ID: 1667252
    [Abstract] [Full Text] [Related]

  • 7. Pharmacokinetics and tolerability of prulifloxacin after single oral administration.
    Picollo R, Brion N, Gualano V, Millérioux L, Marchetti M, Rosignoli MT, Dionisio P.
    Arzneimittelforschung; 2003 Dec; 53(3):201-5. PubMed ID: 12705176
    [Abstract] [Full Text] [Related]

  • 8. Single- and multiple-dose pharmacokinetics of AM-1155, a new 6-fluoro-8-methoxy quinolone, in humans.
    Nakashima M, Uematsu T, Kosuge K, Kusajima H, Ooie T, Masuda Y, Ishida R, Uchida H.
    Antimicrob Agents Chemother; 1995 Dec; 39(12):2635-40. PubMed ID: 8592993
    [Abstract] [Full Text] [Related]

  • 9. [Single-dose toxicity studies of prulifloxacin (NM441) in mice, rats and dogs and the active metabolite (NM394) in rats].
    Shimazu H, Ishikawa Y, Nishiguchi Y, Yoshida M, Iwakura K, Sumi N, Shindo Y.
    J Toxicol Sci; 1996 Jun; 21 Suppl 1():33-44. PubMed ID: 8709168
    [Abstract] [Full Text] [Related]

  • 10. Safety, tolerability and pharmacokinetics of the new long-acting quinolone DW-116 after single and multiple dosing in healthy subjects.
    Meyerhoff C, Dilger C, Yoon SJ, Chung YH, Lee DK, Lee CW, Ryu JM, Choi MS, Pabst G, Reh C.
    J Antimicrob Chemother; 1998 Sep; 42(3):349-61. PubMed ID: 9786475
    [Abstract] [Full Text] [Related]

  • 11. Therapeutic effect of the quinolone prodrug prulifloxacin against experimental urinary tract infections in mice.
    Tomii Y, Ozaki M, Matsuda M, Honmura T, Nishimura I, Yamaguchi R, Adachi T, Okawa Y, Nishino T.
    Arzneimittelforschung; 1996 Dec; 46(12):1169-73. PubMed ID: 9006794
    [Abstract] [Full Text] [Related]

  • 12. [In vitro short-term bactericidal activity and accumulation of NM394, the active metabolite of prulifloxacin, for Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa: comparison with ciprofloxacin, levofloxacin, and gatifloxacin].
    Shimizu M, Tabata M, Hara T, Araake M, Watabe H, Nishino T.
    Jpn J Antibiot; 2002 Dec; 55(6):791-9. PubMed ID: 12621733
    [Abstract] [Full Text] [Related]

  • 13. Paraoxonase has a major role in the hydrolysis of prulifloxacin (NM441), a prodrug of a new antibacterial agent.
    Tougou K, Nakamura A, Watanabe S, Okuyama Y, Morino A.
    Drug Metab Dispos; 1998 Apr; 26(4):355-9. PubMed ID: 9531524
    [Abstract] [Full Text] [Related]

  • 14. [A 4-week intravenous toxicity study of the active metabolite (NM394) of prulifloxacin (NM441) in rats followed by a 4-week recovery test].
    Ishida S, Iketani M, Yamazaki S, Tamura K, Shindo Y, Iwakura K, Sumi N.
    J Toxicol Sci; 1996 Jun; 21 Suppl 1():131-48. PubMed ID: 8709157
    [Abstract] [Full Text] [Related]

  • 15. Pharmacokinetics of grepafloxacin after oral administration of single and repeat doses in healthy young males.
    Efthymiopoulos C, Bramer SL, Maroli A.
    Clin Pharmacokinet; 1997 Jun; 33 Suppl 1():1-8. PubMed ID: 9433650
    [Abstract] [Full Text] [Related]

  • 16. Penetration of NM441, a new quinolone, into human bile and gallbladder tissue.
    Tanimura H, Ishimoto K, Murakami K, Uchiyama K, Iwakura S.
    Drugs; 1995 Jun; 49 Suppl 2():337-40. PubMed ID: 8549354
    [No Abstract] [Full Text] [Related]

  • 17. Pharmacokinetics and tolerance of DU-6859a, a new fluoroquinolone, after single and multiple oral doses in healthy volunteers.
    Nakashima M, Uematsu T, Kosuge K, Umemura K, Hakusui H, Tanaka M.
    Antimicrob Agents Chemother; 1995 Jan; 39(1):170-4. PubMed ID: 7695301
    [Abstract] [Full Text] [Related]

  • 18. Multiple-dose pharmacokinetics of lomefloxacin: rationale for once-a-day dosing.
    Mant TG.
    Am J Med; 1992 Apr 06; 92(4A):26S-32S. PubMed ID: 1316066
    [Abstract] [Full Text] [Related]

  • 19. [Renal toxicity of prulifloxacin (NM441) in rats].
    Kawaminami A, Tawaratani T, Ishibashi S, Oka T, Matsuyama S, Kakemi K, Iwakura K, Sumi N, Shindo Y.
    J Toxicol Sci; 1996 Jun 06; 21 Suppl 1():267-76. PubMed ID: 8709167
    [Abstract] [Full Text] [Related]

  • 20. Transporter-mediated hepatic uptake of ulifloxacin, an active metabolite of a prodrug-type new quinolone antibiotic prulifloxacin, in rats.
    Yagi Y, Aoki M, Iguchi M, Shibasaki S, Kurosawa T, Kato Y, Tsuji A.
    Drug Metab Pharmacokinet; 2007 Oct 06; 22(5):350-7. PubMed ID: 17965518
    [Abstract] [Full Text] [Related]

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