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232 related items for PubMed ID: 7991583

  • 1. Rapid humanization of the Fv of monoclonal antibody B3 by using framework exchange of the recombinant immunotoxin B3(Fv)-PE38.
    Benhar I, Padlan EA, Jung SH, Lee B, Pastan I.
    Proc Natl Acad Sci U S A; 1994 Dec 06; 91(25):12051-5. PubMed ID: 7991583
    [Abstract] [Full Text] [Related]

  • 2. Identification of residues that stabilize the single-chain Fv of monoclonal antibodies B3.
    Benhar I, Pastan I.
    J Biol Chem; 1995 Oct 06; 270(40):23373-80. PubMed ID: 7559495
    [Abstract] [Full Text] [Related]

  • 3. Recombinant immunotoxins containing the VH or VL domain of monoclonal antibody B3 fused to Pseudomonas exotoxin.
    Brinkmann U, Lee BK, Pastan I.
    J Immunol; 1993 Apr 01; 150(7):2774-82. PubMed ID: 8454854
    [Abstract] [Full Text] [Related]

  • 4. Engineering interchain disulfide bonds into conserved framework regions of Fv fragments: improved biochemical characteristics of recombinant immunotoxins containing disulfide-stabilized Fv.
    Reiter Y, Brinkmann U, Webber KO, Jung SH, Lee B, Pastan I.
    Protein Eng; 1994 May 01; 7(5):697-704. PubMed ID: 8073039
    [Abstract] [Full Text] [Related]

  • 5. A recombinant immunotoxin containing a disulfide-stabilized Fv fragment.
    Brinkmann U, Reiter Y, Jung SH, Lee B, Pastan I.
    Proc Natl Acad Sci U S A; 1993 Aug 15; 90(16):7538-42. PubMed ID: 8356052
    [Abstract] [Full Text] [Related]

  • 6. Design of interchain disulfide bonds in the framework region of the Fv fragment of the monoclonal antibody B3.
    Jung SH, Pastan I, Lee B.
    Proteins; 1994 May 15; 19(1):35-47. PubMed ID: 8066084
    [Abstract] [Full Text] [Related]

  • 7. Lowering the isoelectric point of the Fv portion of recombinant immunotoxins leads to decreased nonspecific animal toxicity without affecting antitumor activity.
    Onda M, Nagata S, Tsutsumi Y, Vincent JJ, Wang Q, Kreitman RJ, Lee B, Pastan I.
    Cancer Res; 2001 Jul 01; 61(13):5070-7. PubMed ID: 11431343
    [Abstract] [Full Text] [Related]

  • 8. Characterization of B1(Fv)PE38 and B1(dsFv)PE38: single-chain and disulfide-stabilized Fv immunotoxins with increased activity that cause complete remissions of established human carcinoma xenografts in nude mice.
    Benhar I, Pastan I.
    Clin Cancer Res; 1995 Sep 01; 1(9):1023-9. PubMed ID: 9816075
    [Abstract] [Full Text] [Related]

  • 9. Stabilization of the Fv fragments in recombinant immunotoxins by disulfide bonds engineered into conserved framework regions.
    Reiter Y, Brinkmann U, Kreitman RJ, Jung SH, Lee B, Pastan I.
    Biochemistry; 1994 May 10; 33(18):5451-9. PubMed ID: 7910034
    [Abstract] [Full Text] [Related]

  • 10. Cloning, expression and characterization of the Fv fragments of the anti-carbohydrate mAbs B1 and B5 as single-chain immunotoxins.
    Benhar I, Pastan I.
    Protein Eng; 1994 Dec 10; 7(12):1509-15. PubMed ID: 7716163
    [Abstract] [Full Text] [Related]

  • 11. Administration of disulfide-stabilized Fv-immunotoxins B1(dsFv)-PE38 and B3(dsFv)-PE38 by continuous infusion increases their efficacy in curing large tumor xenografts in nude mice.
    Benhar I, Reiter Y, Pai LH, Pastan I.
    Int J Cancer; 1995 Jul 28; 62(3):351-5. PubMed ID: 7628878
    [Abstract] [Full Text] [Related]

  • 12. Immunotoxins with increased activity against epidermal growth factor receptor vIII-expressing cells produced by antibody phage display.
    Beers R, Chowdhury P, Bigner D, Pastan I.
    Clin Cancer Res; 2000 Jul 28; 6(7):2835-43. PubMed ID: 10914732
    [Abstract] [Full Text] [Related]

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  • 16. B3(Fv)-PE38KDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in mice.
    Brinkmann U, Pai LH, FitzGerald DJ, Willingham M, Pastan I.
    Proc Natl Acad Sci U S A; 1991 Oct 01; 88(19):8616-20. PubMed ID: 1924323
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  • 18. B3(Fab)-PE38M: a recombinant immunotoxin in which a mutant form of Pseudomonas exotoxin is fused to the Fab fragment of monoclonal antibody B3.
    Choe M, Webber KO, Pastan I.
    Cancer Res; 1994 Jul 01; 54(13):3460-7. PubMed ID: 8012967
    [Abstract] [Full Text] [Related]

  • 19. Improved antitumor activity of a recombinant anti-Lewis(y) immunotoxin not requiring proteolytic activation.
    Kuan CT, Pastan I.
    Proc Natl Acad Sci U S A; 1996 Feb 06; 93(3):974-8. PubMed ID: 8577771
    [Abstract] [Full Text] [Related]

  • 20. Cytotoxic and antitumor activity of a recombinant immunotoxin composed of disulfide-stabilized anti-Tac Fv fragment and truncated Pseudomonas exotoxin.
    Reiter Y, Kreitman RJ, Brinkmann U, Pastan I.
    Int J Cancer; 1994 Jul 01; 58(1):142-9. PubMed ID: 8014011
    [Abstract] [Full Text] [Related]

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