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116 related items for PubMed ID: 7996446

  • 1. Enhancement by O6-benzyl-N-acetylguanosine derivatives of chloroethylnitrosourea antitumor action in chloroethylnitrosourea-resistant human malignant melanocytes.
    Cussac C, Rapp M, Mounetou E, Madelmont JC, Maurizis JC, Godeneche D, Dupuy JM, Sauzieres J, Baudry JP, Veyre A.
    J Pharmacol Exp Ther; 1994 Dec; 271(3):1353-8. PubMed ID: 7996446
    [Abstract] [Full Text] [Related]

  • 2. Disposition and metabolism of O6-alkylguanine-DNA alkyltransferase inhibitor in nude mice bearing human melanoma.
    Cussac C, Mounetou E, Rapp M, Madelmont JC, Maurizis JC, Labarre P, Chollet P, Chabard JL, Godeneche D, Baudry JP.
    Drug Metab Dispos; 1994 Dec; 22(4):637-42. PubMed ID: 7956741
    [Abstract] [Full Text] [Related]

  • 3. Enhancement by O6-benzyl-N2-acetylguanosine of N'-[2-chloroethyl]-N-[2-(methylsulphonyl)ethyl]-N'-nitrosourea therapeutic index on nude mice bearing resistant human melanoma.
    Debiton E, Cussac-Buchdhal C, Mounetou E, Rapp M, Dupuy JM, Maurizis JC, Veyre A, Madelmont JC.
    Br J Cancer; 1997 Dec; 76(9):1157-62. PubMed ID: 9365163
    [Abstract] [Full Text] [Related]

  • 4. DNA damage induced by a new 2-chloroethyl nitrosourea on malignant melanoma cells.
    Godeneche D, Rapp M, Thierry A, Laval F, Madelmont JC, Chollet P, Veyre A.
    Cancer Res; 1990 Sep 15; 50(18):5898-903. PubMed ID: 2393861
    [Abstract] [Full Text] [Related]

  • 5. Inhibition of O6-alkylguanine-DNA alkyltransferase by O6-benzyl-N2-acetylguanosine increases chloroethylnitrosourea-induced apoptosis in Mer+ human melanoma cells.
    Debiton E, Glasser AL, Marchenay C, Rolhion C, Maurizis JC, Madelmont JC.
    Melanoma Res; 2002 Oct 15; 12(5):417-27. PubMed ID: 12394182
    [Abstract] [Full Text] [Related]

  • 6. O6-(alkyl/aralkyl)guanosine and 2'-deoxyguanosine derivatives: synthesis and ability to enhance chloroethylnitrosourea antitumor action.
    Mounetou E, Debiton E, Buchdahl C, Gardette D, Gramain JC, Maurizis JC, Veyre A, Madelmont JC.
    J Med Chem; 1997 Aug 29; 40(18):2902-9. PubMed ID: 9288172
    [Abstract] [Full Text] [Related]

  • 7. Melanoma-cell toxicity of cystemustine combined with O6-benzyl-N2-acetylguanosine.
    Buchdahl C, Rolhion C, Glasser AL, Debiton E, Mounetou E, Madelmont JC, Laval F.
    Melanoma Res; 1998 Apr 29; 8(2):123-30. PubMed ID: 9610864
    [Abstract] [Full Text] [Related]

  • 8. A new O6-alkylguanine-DNA alkyltransferase inhibitor associated with a nitrosourea (cystemustine) validates a strategy of melanoma-targeted therapy in murine B16 and human-resistant M4Beu melanoma xenograft models.
    Rapp M, Maurizis JC, Papon J, Labarre P, Wu TD, Croisy A, Guerquin-Kern JL, Madelmont JC, Mounetou E.
    J Pharmacol Exp Ther; 2008 Jul 29; 326(1):171-7. PubMed ID: 18411412
    [Abstract] [Full Text] [Related]

  • 9. [Modulation of the antitumor activity of 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosoure a by O(6)-methyl-2'-deoxyguanosine--a new inhibitor of O(6)-alkylguanine-DNA-alkyltransferase].
    Dederer LIu, Sokolova IS, Bakhmedova AA, Miniker TD, Mel'nik SIa, Gorbacheva LB.
    Biokhimiia; 1995 Sep 29; 60(9):1521-9. PubMed ID: 8562657
    [Abstract] [Full Text] [Related]

  • 10. Activity of fotemustine in medulloblastoma and malignant glioma xenografts in relation to O6-alkylguanine-DNA alkyltransferase and alkylpurine-DNA N-glycosylase activity.
    Vassal G, Boland I, Terrier-Lacombe MJ, Watson AJ, Margison GP, Vénuat AM, Morizet J, Parker F, Lacroix C, Lellouch-Tubiana A, Pierre-Kahn A, Poullain MG, Gouyette A.
    Clin Cancer Res; 1998 Feb 29; 4(2):463-8. PubMed ID: 9516937
    [Abstract] [Full Text] [Related]

  • 11. Cystemustine induces redifferentiation of primary tumors and confers protection against secondary tumor growth in a melanoma murine model.
    Demidem A, Morvan D, Papon J, De Latour M, Madelmont JC.
    Cancer Res; 2001 Mar 01; 61(5):2294-300. PubMed ID: 11280801
    [Abstract] [Full Text] [Related]

  • 12. Effect of O6-methylguanine on DNA interstrand cross-link formation by chloroethylnitrosoureas and 2-chloroethyl(methylsulfonyl)methanesulfonate.
    Dolan ME, Pegg AE, Hora NK, Erickson LC.
    Cancer Res; 1988 Jul 01; 48(13):3603-6. PubMed ID: 2837318
    [Abstract] [Full Text] [Related]

  • 13. [Effect of pretreatment with N-methyl-N-nitrosourea or streptozotocin on the cytotoxicity and the induction of sister chromatid exchanges in human and rodent brain tumor cells treated with chloroethylnitrosourea].
    Tokuda K.
    Hokkaido Igaku Zasshi; 1992 Jul 01; 67(4):462-74. PubMed ID: 1427592
    [Abstract] [Full Text] [Related]

  • 14. Treatment of human brain tumor xenografts with O6-benzyl-2'-deoxyguanosine and BCNU.
    Schold SC, Kokkinakis DM, Rudy JL, Moschel RC, Pegg AE.
    Cancer Res; 1996 May 01; 56(9):2076-81. PubMed ID: 8616853
    [Abstract] [Full Text] [Related]

  • 15. Potentiation of nitrosourea cytotoxicity in human leukemic cells by inactivation of O6-alkylguanine-DNA alkyltransferase.
    Gerson SL, Trey JE, Miller K.
    Cancer Res; 1988 Mar 15; 48(6):1521-7. PubMed ID: 3162197
    [Abstract] [Full Text] [Related]

  • 16. [Study on potentiation of nitrosourea-cytotoxicity by DNA repair enzyme inhibitors in human brain tumor cells].
    Fukuchi M, Mineura K, Kowada M, Terashima I, Kohda K.
    No To Shinkei; 1997 Jun 15; 49(6):521-8. PubMed ID: 9198092
    [Abstract] [Full Text] [Related]

  • 17. Effect of O6-alkylguanine pretreatment on the sensitivity of human colon tumor cells to the cytotoxic effects of chloroethylating agents.
    Dolan ME, Young GS, Pegg AE.
    Cancer Res; 1986 Sep 15; 46(9):4500-4. PubMed ID: 3015389
    [Abstract] [Full Text] [Related]

  • 18. Acquisition of resistance to 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride in V79 cells through increased removal of O6-alkylguanine.
    Satoh MS, Huh NH, Horie Y, Thomale J, Rajewsky MF, Kuroki T.
    Jpn J Cancer Res; 1987 Oct 15; 78(10):1094-9. PubMed ID: 3119542
    [Abstract] [Full Text] [Related]

  • 19. Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents.
    Dolan ME, Mitchell RB, Mummert C, Moschel RC, Pegg AE.
    Cancer Res; 1991 Jul 01; 51(13):3367-72. PubMed ID: 1647266
    [Abstract] [Full Text] [Related]

  • 20. Pharmacokinetics and metabolism in rats of 2,4-diamino-6-benzyloxy-5- nitrosopyrimidine, an inactivator of O6-alkylguanine-DNA alkyltransferase.
    Roy SK, Moschel RC, Dolan ME.
    Drug Metab Dispos; 1996 Nov 01; 24(11):1205-11. PubMed ID: 8937854
    [Abstract] [Full Text] [Related]

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