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Journal Abstract Search

189 related items for PubMed ID: 7998967

  • 1. Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan.
    Fosang AJ, Last K, Neame PJ, Murphy G, Knäuper V, Tschesche H, Hughes CE, Caterson B, Hardingham TE.
    Biochem J; 1994 Dec 01; 304 ( Pt 2)(Pt 2):347-51. PubMed ID: 7998967
    [Abstract] [Full Text] [Related]

  • 2. Membrane type 1 matrix metalloproteinase (MT1-MMP) cleaves the recombinant aggrecan substrate rAgg1mut at the 'aggrecanase' and the MMP sites. Characterization of MT1-MMP catabolic activities on the interglobular domain of aggrecan.
    Büttner FH, Hughes CE, Margerie D, Lichte A, Tschesche H, Caterson B, Bartnik E.
    Biochem J; 1998 Jul 01; 333 ( Pt 1)(Pt 1):159-65. PubMed ID: 9639575
    [Abstract] [Full Text] [Related]

  • 3. The interglobular domain of cartilage aggrecan is cleaved by hemorrhagic metalloproteinase HT-d (atrolysin C) at the matrix metalloproteinase and aggrecanase sites.
    Tortorella MD, Pratta MA, Fox JW, Arner EC.
    J Biol Chem; 1998 Mar 06; 273(10):5846-50. PubMed ID: 9488721
    [Abstract] [Full Text] [Related]

  • 4. Cleavage of native cartilage aggrecan by neutrophil collagenase (MMP-8) is distinct from endogenous cleavage by aggrecanase.
    Arner EC, Decicco CP, Cherney R, Tortorella MD.
    J Biol Chem; 1997 Apr 04; 272(14):9294-9. PubMed ID: 9083065
    [Abstract] [Full Text] [Related]

  • 5. Mutations in the interglobular domain of aggrecan alter matrix metalloproteinase and aggrecanase cleavage patterns. Evidence that matrix metalloproteinase cleavage interferes with aggrecanase activity.
    Mercuri FA, Maciewicz RA, Tart J, Last K, Fosang AJ.
    J Biol Chem; 2000 Oct 20; 275(42):33038-45. PubMed ID: 11032846
    [Abstract] [Full Text] [Related]

  • 6. Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain.
    Fosang AJ, Last K, Knäuper V, Neame PJ, Murphy G, Hardingham TE, Tschesche H, Hamilton JA.
    Biochem J; 1993 Oct 01; 295 ( Pt 1)(Pt 1):273-6. PubMed ID: 8216228
    [Abstract] [Full Text] [Related]

  • 7. Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro.
    Little CB, Flannery CR, Hughes CE, Mort JS, Roughley PJ, Dent C, Caterson B.
    Biochem J; 1999 Nov 15; 344 Pt 1(Pt 1):61-8. PubMed ID: 10548534
    [Abstract] [Full Text] [Related]

  • 8. Degradation of cartilage aggrecan by collagenase-3 (MMP-13).
    Fosang AJ, Last K, Knäuper V, Murphy G, Neame PJ.
    FEBS Lett; 1996 Feb 12; 380(1-2):17-20. PubMed ID: 8603731
    [Abstract] [Full Text] [Related]

  • 9. Development of a cleavage-site-specific monoclonal antibody for detecting metalloproteinase-derived aggrecan fragments: detection of fragments in human synovial fluids.
    Fosang AJ, Last K, Gardiner P, Jackson DC, Brown L.
    Biochem J; 1995 Aug 15; 310 ( Pt 1)(Pt 1):337-43. PubMed ID: 7544117
    [Abstract] [Full Text] [Related]

  • 10. Quantification of a matrix metalloproteinase-generated aggrecan G1 fragment using monospecific anti-peptide serum.
    Lark MW, Williams H, Hoernner LA, Weidner J, Ayala JM, Harper CF, Christen A, Olszewski J, Konteatis Z, Webber R.
    Biochem J; 1995 Apr 01; 307 ( Pt 1)(Pt 1):245-52. PubMed ID: 7717983
    [Abstract] [Full Text] [Related]

  • 11. Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro.
    Hughes CE, Caterson B, Fosang AJ, Roughley PJ, Mort JS.
    Biochem J; 1995 Feb 01; 305 ( Pt 3)(Pt 3):799-804. PubMed ID: 7531436
    [Abstract] [Full Text] [Related]

  • 12. Membrane-type 1 MMP (MMP-14) cleaves at three sites in the aggrecan interglobular domain.
    Fosang AJ, Last K, Fujii Y, Seiki M, Okada Y.
    FEBS Lett; 1998 Jul 03; 430(3):186-90. PubMed ID: 9688535
    [Abstract] [Full Text] [Related]

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  • 15. Truncation of the amino-terminus of the recombinant aggrecan rAgg1mut leads to reduced cleavage at the aggrecanase site. Efficient aggrecanase catabolism may depend on multiple substrate interactions.
    Hörber C, Büttner FH, Kern C, Schmiedeknecht G, Bartnik E.
    Matrix Biol; 2000 Nov 03; 19(6):533-43. PubMed ID: 11068207
    [Abstract] [Full Text] [Related]

  • 16. The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B.
    Fosang AJ, Neame PJ, Last K, Hardingham TE, Murphy G, Hamilton JA.
    J Biol Chem; 1992 Sep 25; 267(27):19470-4. PubMed ID: 1326552
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  • 18. An aggrecan-degrading activity associated with chondrocyte membranes.
    Billington CJ, Clark IM, Cawston TE.
    Biochem J; 1998 Nov 15; 336 ( Pt 1)(Pt 1):207-12. PubMed ID: 9806902
    [Abstract] [Full Text] [Related]

  • 19. Aggrecanase and metalloproteinase-specific aggrecan neo-epitopes are induced in the articular cartilage of mice with collagen II-induced arthritis.
    Singer II, Scott S, Kawka DW, Bayne EK, Weidner JR, Williams HR, Mumford RA, Lark MW, McDonnell J, Christen AJ, Moore VL, Mudgett JS, Visco DM.
    Osteoarthritis Cartilage; 1997 Nov 15; 5(6):407-18. PubMed ID: 9536289
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