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Journal Abstract Search

343 related items for PubMed ID: 8014011

  • 1. Cytotoxic and antitumor activity of a recombinant immunotoxin composed of disulfide-stabilized anti-Tac Fv fragment and truncated Pseudomonas exotoxin.
    Reiter Y, Kreitman RJ, Brinkmann U, Pastan I.
    Int J Cancer; 1994 Jul 01; 58(1):142-9. PubMed ID: 8014011
    [Abstract] [Full Text] [Related]

  • 2. Improved binding and antitumor activity of a recombinant anti-erbB2 immunotoxin by disulfide stabilization of the Fv fragment.
    Reiter Y, Brinkmann U, Jung SH, Lee B, Kasprzyk PG, King CR, Pastan I.
    J Biol Chem; 1994 Jul 15; 269(28):18327-31. PubMed ID: 7913461
    [Abstract] [Full Text] [Related]

  • 3. Antitumor activity and pharmacokinetics in mice of a recombinant immunotoxin containing a disulfide-stabilized Fv fragment.
    Reiter Y, Pai LH, Brinkmann U, Wang QC, Pastan I.
    Cancer Res; 1994 May 15; 54(10):2714-8. PubMed ID: 8168102
    [Abstract] [Full Text] [Related]

  • 4. Stabilization of the Fv fragments in recombinant immunotoxins by disulfide bonds engineered into conserved framework regions.
    Reiter Y, Brinkmann U, Kreitman RJ, Jung SH, Lee B, Pastan I.
    Biochemistry; 1994 May 10; 33(18):5451-9. PubMed ID: 7910034
    [Abstract] [Full Text] [Related]

  • 5. Engineering interchain disulfide bonds into conserved framework regions of Fv fragments: improved biochemical characteristics of recombinant immunotoxins containing disulfide-stabilized Fv.
    Reiter Y, Brinkmann U, Webber KO, Jung SH, Lee B, Pastan I.
    Protein Eng; 1994 May 10; 7(5):697-704. PubMed ID: 8073039
    [Abstract] [Full Text] [Related]

  • 6. Recombinant single-chain and disulfide-stabilized Fv-immunotoxins that cause complete regression of a human colon cancer xenograft in nude mice.
    Reiter Y, Wright AF, Tonge DW, Pastan I.
    Int J Cancer; 1996 Jul 03; 67(1):113-23. PubMed ID: 8690511
    [Abstract] [Full Text] [Related]

  • 7. A recombinant immunotoxin containing a disulfide-stabilized Fv fragment.
    Brinkmann U, Reiter Y, Jung SH, Lee B, Pastan I.
    Proc Natl Acad Sci U S A; 1993 Aug 15; 90(16):7538-42. PubMed ID: 8356052
    [Abstract] [Full Text] [Related]

  • 8. Characterization of B1(Fv)PE38 and B1(dsFv)PE38: single-chain and disulfide-stabilized Fv immunotoxins with increased activity that cause complete remissions of established human carcinoma xenografts in nude mice.
    Benhar I, Pastan I.
    Clin Cancer Res; 1995 Sep 15; 1(9):1023-9. PubMed ID: 9816075
    [Abstract] [Full Text] [Related]

  • 9. Recombinant immunotoxin containing a disulfide-stabilized Fv directed at erbB2 that does not require proteolytic activation.
    Kuan CT, Pastan I.
    Biochemistry; 1996 Mar 05; 35(9):2872-7. PubMed ID: 8608123
    [Abstract] [Full Text] [Related]

  • 10. Bivalent disulfide-stabilized fragment variable immunotoxin directed against mesotheliomas and ovarian cancer.
    Bera TK, Williams-Gould J, Beers R, Chowdhury P, Pastan I.
    Mol Cancer Ther; 2001 Dec 05; 1(2):79-84. PubMed ID: 12467225
    [Abstract] [Full Text] [Related]

  • 11. Administration of disulfide-stabilized Fv-immunotoxins B1(dsFv)-PE38 and B3(dsFv)-PE38 by continuous infusion increases their efficacy in curing large tumor xenografts in nude mice.
    Benhar I, Reiter Y, Pai LH, Pastan I.
    Int J Cancer; 1995 Jul 28; 62(3):351-5. PubMed ID: 7628878
    [Abstract] [Full Text] [Related]

  • 12. Anti-Tac(Fab)-PE40, a recombinant double-chain immunotoxin which kills interleukin-2-receptor-bearing cells and induces complete remission in an in vivo tumor model.
    Kreitman RJ, Chang CN, Hudson DV, Queen C, Bailon P, Pastan I.
    Int J Cancer; 1994 Jun 15; 57(6):856-64. PubMed ID: 8206679
    [Abstract] [Full Text] [Related]

  • 13. Lowering the isoelectric point of the Fv portion of recombinant immunotoxins leads to decreased nonspecific animal toxicity without affecting antitumor activity.
    Onda M, Nagata S, Tsutsumi Y, Vincent JJ, Wang Q, Kreitman RJ, Lee B, Pastan I.
    Cancer Res; 2001 Jul 01; 61(13):5070-7. PubMed ID: 11431343
    [Abstract] [Full Text] [Related]

  • 14. Improved antitumor activity of a recombinant anti-Lewis(y) immunotoxin not requiring proteolytic activation.
    Kuan CT, Pastan I.
    Proc Natl Acad Sci U S A; 1996 Feb 06; 93(3):974-8. PubMed ID: 8577771
    [Abstract] [Full Text] [Related]

  • 15. A bivalent disulfide-stabilized Fv with improved antigen binding to erbB2.
    Bera TK, Onda M, Brinkmann U, Pastan I.
    J Mol Biol; 1998 Aug 21; 281(3):475-83. PubMed ID: 9698563
    [Abstract] [Full Text] [Related]

  • 16. Recombinant immunotoxins containing anti-Tac(Fv) and derivatives of Pseudomonas exotoxin produce complete regression in mice of an interleukin-2 receptor-expressing human carcinoma.
    Kreitman RJ, Bailon P, Chaudhary VK, FitzGerald DJ, Pastan I.
    Blood; 1994 Jan 15; 83(2):426-34. PubMed ID: 8286741
    [Abstract] [Full Text] [Related]

  • 17. Single-chain immunotoxin fusions between anti-Tac and Pseudomonas exotoxin: relative importance of the two toxin disulfide bonds.
    Kreitman RJ, Batra JK, Seetharam S, Chaudhary VK, FitzGerald DJ, Pastan I.
    Bioconjug Chem; 1993 Jan 15; 4(2):112-20. PubMed ID: 7873642
    [Abstract] [Full Text] [Related]

  • 18. Accumulation of a recombinant immunotoxin in a tumor in vivo: fewer than 1000 molecules per cell are sufficient for complete responses.
    Kreitman RJ, Pastan I.
    Cancer Res; 1998 Mar 01; 58(5):968-75. PubMed ID: 9500458
    [Abstract] [Full Text] [Related]

  • 19. Recombinant single-chain immunotoxins against T and B cell leukemias.
    Kreitman RJ, Pastan I.
    Leuk Lymphoma; 1994 Mar 01; 13(1-2):1-10. PubMed ID: 8025511
    [Abstract] [Full Text] [Related]

  • 20. Pharmacokinetics and antitumor activity of a bivalent disulfide-stabilized Fv immunotoxin with improved antigen binding to erbB2.
    Bera TK, Viner J, Brinkmann E, Pastan I.
    Cancer Res; 1999 Aug 15; 59(16):4018-22. PubMed ID: 10463601
    [Abstract] [Full Text] [Related]

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