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Journal Abstract Search

129 related items for PubMed ID: 8027066

  • 1. The functions of the human insulin receptor are affected in different ways by mutation of each of the four N-glycosylation sites in the beta subunit.
    Leconte I, Carpentier JL, Clauser E.
    J Biol Chem; 1994 Jul 08; 269(27):18062-71. PubMed ID: 8027066
    [Abstract] [Full Text] [Related]

  • 2. N-linked oligosaccharide chains of the insulin receptor beta subunit are essential for transmembrane signaling.
    Leconte I, Auzan C, Debant A, Rossi B, Clauser E.
    J Biol Chem; 1992 Aug 25; 267(24):17415-23. PubMed ID: 1324936
    [Abstract] [Full Text] [Related]

  • 3. Two sequences flanking the major autophosphorylation site of the insulin receptor are essential for tyrosine kinase activation.
    Leconte I, Clauser E.
    Biochem J; 1995 Mar 01; 306 ( Pt 2)(Pt 2):465-72. PubMed ID: 7887900
    [Abstract] [Full Text] [Related]

  • 4. Insulin receptor kinase domain autophosphorylation regulates receptor enzymatic function.
    Wilden PA, Kahn CR, Siddle K, White MF.
    J Biol Chem; 1992 Aug 15; 267(23):16660-8. PubMed ID: 1322912
    [Abstract] [Full Text] [Related]

  • 5. Two naturally occurring mutant insulin receptors phosphorylate insulin receptor substrate-1 (IRS-1) but fail to mediate the biological effects of insulin. Evidence that IRS-1 phosphorylation is not sufficient for normal insulin action.
    Krook A, Moller DE, Dib K, O'Rahilly S.
    J Biol Chem; 1996 Mar 22; 271(12):7134-40. PubMed ID: 8636149
    [Abstract] [Full Text] [Related]

  • 6. Enhanced insulin-induced mitogenesis and mitogen-activated protein kinase activities in mutant insulin receptors with substitution of two COOH-terminal tyrosine autophosphorylation sites by phenylalanine.
    Ando A, Momomura K, Tobe K, Yamamoto-Honda R, Sakura H, Tamori Y, Kaburagi Y, Koshio O, Akanuma Y, Yazaki Y.
    J Biol Chem; 1992 Jun 25; 267(18):12788-96. PubMed ID: 1618780
    [Abstract] [Full Text] [Related]

  • 7. Mutational analysis of the N-linked glycosylation sites of the human insulin receptor.
    Elleman TC, Frenkel MJ, Hoyne PA, McKern NM, Cosgrove L, Hewish DR, Jachno KM, Bentley JD, Sankovich SE, Ward CW.
    Biochem J; 2000 May 01; 347 Pt 3(Pt 3):771-9. PubMed ID: 10769182
    [Abstract] [Full Text] [Related]

  • 8. Site-directed mutagenesis of the juxtamembrane domain of the human insulin receptor.
    Kaburagi Y, Momomura K, Yamamoto-Honda R, Tobe K, Tamori Y, Sakura H, Akanuma Y, Yazaki Y, Kadowaki T.
    J Biol Chem; 1993 Aug 05; 268(22):16610-22. PubMed ID: 8393870
    [Abstract] [Full Text] [Related]

  • 9. Deletion of C-terminal 113 amino acids impairs processing and internalization of human insulin receptor: comparison of receptors expressed in CHO and NIH-3T3 cells.
    Levy-Toledano R, Accili D, Taylor SI.
    Biochim Biophys Acta; 1993 Dec 16; 1220(1):1-14. PubMed ID: 8268238
    [Abstract] [Full Text] [Related]

  • 10. Cleavage site mutants of the subtype B insulin receptor are uncleaved and fully functional.
    Auzan C, Debant A, Rossi B, Clauser E.
    Mol Cell Endocrinol; 1997 Apr 04; 128(1-2):129-37. PubMed ID: 9140084
    [Abstract] [Full Text] [Related]

  • 11. Human insulin receptor mutated at threonine 1336 functions normally in Chinese hamster ovary cells.
    Ahn J, Rosen OM, Donner DB.
    J Biol Chem; 1993 Aug 05; 268(22):16839-44. PubMed ID: 8393875
    [Abstract] [Full Text] [Related]

  • 12. An arginine to cysteine(252) mutation in insulin receptors from a patient with severe insulin resistance inhibits receptor internalisation but preserves signalling events.
    Hamer I, Foti M, Emkey R, Cordier-Bussat M, Philippe J, De Meyts P, Maeder C, Kahn CR, Carpentier JL.
    Diabetologia; 2002 May 05; 45(5):657-67. PubMed ID: 12107746
    [Abstract] [Full Text] [Related]

  • 13. Substitution of the insulin receptor transmembrane domain with the c-neu/erbB2 transmembrane domain constitutively activates the insulin receptor kinase in vitro.
    Yamada K, Goncalves E, Kahn CR, Shoelson SE.
    J Biol Chem; 1992 Jun 25; 267(18):12452-61. PubMed ID: 1352286
    [Abstract] [Full Text] [Related]

  • 14. Two naturally occurring insulin receptor tyrosine kinase domain mutants provide evidence that phosphoinositide 3-kinase activation alone is not sufficient for the mediation of insulin's metabolic and mitogenic effects.
    Krook A, Whitehead JP, Dobson SP, Griffiths MR, Ouwens M, Baker C, Hayward AC, Sen SK, Maassen JA, Siddle K, Tavaré JM, O'Rahilly S.
    J Biol Chem; 1997 Nov 28; 272(48):30208-14. PubMed ID: 9374504
    [Abstract] [Full Text] [Related]

  • 15. Site-Directed Mutagenesis of the Fibronectin Domains in Insulin Receptor-Related Receptor.
    Deyev IE, Chachina NA, Zhevlenev ES, Petrenko AG.
    Int J Mol Sci; 2017 Nov 19; 18(11):. PubMed ID: 29156593
    [Abstract] [Full Text] [Related]

  • 16. An extracellular domain of the beta subunit is essential for processing, transport and kinase activity of insulin receptor.
    Haruta T, Sawa T, Takata Y, Imamura T, Takada Y, Morioka H, Yang GH, Kobayashi M.
    Biochem J; 1995 Jan 15; 305 ( Pt 2)(Pt 2):599-604. PubMed ID: 7832779
    [Abstract] [Full Text] [Related]

  • 17. Site-specific roles of N-linked oligosaccharides in recombinant eel follicle-stimulating hormone for secretion and signal transduction.
    Kim JM, Munkhuu O, Byambaragchaa M, Lee BI, Kim SK, Kang MH, Kim DJ, Min KS.
    Gen Comp Endocrinol; 2019 May 15; 276():37-44. PubMed ID: 30836102
    [Abstract] [Full Text] [Related]

  • 18. The insulin receptor functions normally in Chinese hamster ovary cells after truncation of the C terminus.
    Myers MG, Backer JM, Siddle K, White MF.
    J Biol Chem; 1991 Jun 05; 266(16):10616-23. PubMed ID: 1645354
    [Abstract] [Full Text] [Related]

  • 19. Activation of insulin receptor signaling by a single amino acid substitution in the transmembrane domain.
    Longo N, Shuster RC, Griffin LD, Langley SD, Elsas LJ.
    J Biol Chem; 1992 Jun 25; 267(18):12416-9. PubMed ID: 1618747
    [Abstract] [Full Text] [Related]

  • 20. Specific glycosylation site mutations of the insulin receptor alpha subunit impair intracellular transport.
    Collier E, Carpentier JL, Beitz L, Carol H, Taylor SI, Gorden P.
    Biochemistry; 1993 Aug 03; 32(30):7818-23. PubMed ID: 8347587
    [Abstract] [Full Text] [Related]

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