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2. The P6-P2 region of serpins is critical for proteinase inhibition and complex stability. Chaillan-Huntington CE, Gettins PG, Huntington JA, Patston PA. Biochemistry; 1997 Aug 05; 36(31):9562-70. PubMed ID: 9236002 [Abstract] [Full Text] [Related]
3. Influence of the P5 residue on alpha1-proteinase inhibitor mechanism. Chaillan-Huntington CE, Patston PA. J Biol Chem; 1998 Feb 20; 273(8):4569-73. PubMed ID: 9468513 [Abstract] [Full Text] [Related]
4. Single amino acid substitutions in recombinant plant-derived human α1-proteinase inhibitor confer enhanced stability and functional efficacy. Jha S, Sanyal I, Amla DV. Biochim Biophys Acta; 2014 Jan 20; 1840(1):416-27. PubMed ID: 24090883 [Abstract] [Full Text] [Related]
5. alpha1-Proteinase inhibitor forms initial non-covalent and final covalent complexes with elastase analogously to other serpin-proteinase pairs, suggesting a common mechanism of inhibition. Dobó J, Gettins PG. J Biol Chem; 2004 Mar 05; 279(10):9264-9. PubMed ID: 14593107 [Abstract] [Full Text] [Related]
6. Full or partial substitution of the reactive center loop of alpha-1-proteinase inhibitor by that of heparin cofactor II: P1 Arg is required for maximal thrombin inhibition. Filion ML, Bhakta V, Nguyen LH, Liaw PS, Sheffield WP. Biochemistry; 2004 Nov 23; 43(46):14864-72. PubMed ID: 15544357 [Abstract] [Full Text] [Related]
7. Formation of a noncovalent serpin-proteinase complex involves no conformational change in the serpin. Use of 1H-15N HSQC NMR as a sensitive nonperturbing monitor of conformation. Peterson FC, Gordon NC, Gettins PG. Biochemistry; 2000 Oct 03; 39(39):11884-92. PubMed ID: 11009600 [Abstract] [Full Text] [Related]
8. Active site distortion is sufficient for proteinase inhibition by serpins: structure of the covalent complex of alpha1-proteinase inhibitor with porcine pancreatic elastase. Dementiev A, Dobó J, Gettins PG. J Biol Chem; 2006 Feb 10; 281(6):3452-7. PubMed ID: 16321984 [Abstract] [Full Text] [Related]
9. Insight into the mechanism of serpin-proteinase inhibition from 2D [1H-15N] NMR studies of the 69 kDa alpha 1-proteinase inhibitor Pittsburgh-trypsin covalent complex. Peterson FC, Gettins PG. Biochemistry; 2001 May 29; 40(21):6284-92. PubMed ID: 11371190 [Abstract] [Full Text] [Related]
10. Role of the P6-P3' region of the serpin reactive loop in the formation and breakdown of the inhibitory complex. Plotnick MI, Schechter NM, Wang ZM, Liu X, Rubin H. Biochemistry; 1997 Nov 25; 36(47):14601-8. PubMed ID: 9398179 [Abstract] [Full Text] [Related]
11. Serpin conformational change in ovalbumin. Enhanced reactive center loop insertion through hinge region mutations. Huntington JA, Fan B, Karlsson KE, Deinum J, Lawrence DA, Gettins PG. Biochemistry; 1997 May 06; 36(18):5432-40. PubMed ID: 9154925 [Abstract] [Full Text] [Related]
12. Role of the P2 residue of human alpha 1-antitrypsin in determining target protease specificity. Chung HS, Kim JS, Lee SM, Park SJ. PLoS One; 2017 May 06; 12(9):e0185074. PubMed ID: 28922398 [Abstract] [Full Text] [Related]
13. S-ovalbumin, an ovalbumin conformer with properties analogous to those of loop-inserted serpins. Huntington JA, Patston PA, Gettins PG. Protein Sci; 1995 Apr 06; 4(4):613-21. PubMed ID: 7613461 [Abstract] [Full Text] [Related]
15. Inhibitory activity and conformational transition of alpha 1-proteinase inhibitor variants. Schulze AJ, Huber R, Degryse E, Speck D, Bischoff R. Eur J Biochem; 1991 Dec 18; 202(3):1147-55. PubMed ID: 1765073 [Abstract] [Full Text] [Related]
16. Effects of mutations in the hinge region of serpins. Hopkins PC, Carrell RW, Stone SR. Biochemistry; 1993 Aug 03; 32(30):7650-7. PubMed ID: 8347575 [Abstract] [Full Text] [Related]
17. Functional diversification during evolution of the murine alpha(1)-proteinase inhibitor family: role of the hypervariable reactive center loop. Barbour KW, Goodwin RL, Guillonneau F, Wang Y, Baumann H, Berger FG. Mol Biol Evol; 2002 May 03; 19(5):718-27. PubMed ID: 11961105 [Abstract] [Full Text] [Related]
18. Evidence for the extent of insertion of the active site loop of intact alpha 1 proteinase inhibitor in beta-sheet A. Schulze AJ, Frohnert PW, Engh RA, Huber R. Biochemistry; 1992 Aug 25; 31(33):7560-5. PubMed ID: 1510942 [Abstract] [Full Text] [Related]
20. Differential inhibition of serine proteinases by rabbit alpha 1-proteinase inhibitors F and S. Koj A, Regoeczi E. Int J Pept Protein Res; 1981 Apr 25; 17(4):519-26. PubMed ID: 6458574 [Abstract] [Full Text] [Related] Page: [Next] [New Search]