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154 related items for PubMed ID: 8066084

  • 1. Design of interchain disulfide bonds in the framework region of the Fv fragment of the monoclonal antibody B3.
    Jung SH, Pastan I, Lee B.
    Proteins; 1994 May; 19(1):35-47. PubMed ID: 8066084
    [Abstract] [Full Text] [Related]

  • 2. Engineering interchain disulfide bonds into conserved framework regions of Fv fragments: improved biochemical characteristics of recombinant immunotoxins containing disulfide-stabilized Fv.
    Reiter Y, Brinkmann U, Webber KO, Jung SH, Lee B, Pastan I.
    Protein Eng; 1994 May; 7(5):697-704. PubMed ID: 8073039
    [Abstract] [Full Text] [Related]

  • 3. Stabilization of the Fv fragments in recombinant immunotoxins by disulfide bonds engineered into conserved framework regions.
    Reiter Y, Brinkmann U, Kreitman RJ, Jung SH, Lee B, Pastan I.
    Biochemistry; 1994 May 10; 33(18):5451-9. PubMed ID: 7910034
    [Abstract] [Full Text] [Related]

  • 4. Rapid humanization of the Fv of monoclonal antibody B3 by using framework exchange of the recombinant immunotoxin B3(Fv)-PE38.
    Benhar I, Padlan EA, Jung SH, Lee B, Pastan I.
    Proc Natl Acad Sci U S A; 1994 Dec 06; 91(25):12051-5. PubMed ID: 7991583
    [Abstract] [Full Text] [Related]

  • 5. Identification of residues that stabilize the single-chain Fv of monoclonal antibodies B3.
    Benhar I, Pastan I.
    J Biol Chem; 1995 Oct 06; 270(40):23373-80. PubMed ID: 7559495
    [Abstract] [Full Text] [Related]

  • 6. A recombinant immunotoxin containing a disulfide-stabilized Fv fragment.
    Brinkmann U, Reiter Y, Jung SH, Lee B, Pastan I.
    Proc Natl Acad Sci U S A; 1993 Aug 15; 90(16):7538-42. PubMed ID: 8356052
    [Abstract] [Full Text] [Related]

  • 7. Crystal structure of the disulfide-stabilized Fv fragment of anticancer antibody B1: conformational influence of an engineered disulfide bond.
    Almog O, Benhar I, Vasmatzis G, Tordova M, Lee B, Pastan I, Gilliland GL.
    Proteins; 1998 May 01; 31(2):128-38. PubMed ID: 9593187
    [Abstract] [Full Text] [Related]

  • 8. Recombinant immunotoxins containing the VH or VL domain of monoclonal antibody B3 fused to Pseudomonas exotoxin.
    Brinkmann U, Lee BK, Pastan I.
    J Immunol; 1993 Apr 01; 150(7):2774-82. PubMed ID: 8454854
    [Abstract] [Full Text] [Related]

  • 9. Characterization of B1(Fv)PE38 and B1(dsFv)PE38: single-chain and disulfide-stabilized Fv immunotoxins with increased activity that cause complete remissions of established human carcinoma xenografts in nude mice.
    Benhar I, Pastan I.
    Clin Cancer Res; 1995 Sep 01; 1(9):1023-9. PubMed ID: 9816075
    [Abstract] [Full Text] [Related]

  • 10. Recombinant immunotoxin containing a disulfide-stabilized Fv directed at erbB2 that does not require proteolytic activation.
    Kuan CT, Pastan I.
    Biochemistry; 1996 Mar 05; 35(9):2872-7. PubMed ID: 8608123
    [Abstract] [Full Text] [Related]

  • 11. A method for increasing the yield of properly folded recombinant fusion proteins: single-chain immunotoxins from renaturation of bacterial inclusion bodies.
    Buchner J, Pastan I, Brinkmann U.
    Anal Biochem; 1992 Sep 05; 205(2):263-70. PubMed ID: 1332541
    [Abstract] [Full Text] [Related]

  • 12. B3(Fab)-PE38M: a recombinant immunotoxin in which a mutant form of Pseudomonas exotoxin is fused to the Fab fragment of monoclonal antibody B3.
    Choe M, Webber KO, Pastan I.
    Cancer Res; 1994 Jul 01; 54(13):3460-7. PubMed ID: 8012967
    [Abstract] [Full Text] [Related]

  • 13. Administration of disulfide-stabilized Fv-immunotoxins B1(dsFv)-PE38 and B3(dsFv)-PE38 by continuous infusion increases their efficacy in curing large tumor xenografts in nude mice.
    Benhar I, Reiter Y, Pai LH, Pastan I.
    Int J Cancer; 1995 Jul 28; 62(3):351-5. PubMed ID: 7628878
    [Abstract] [Full Text] [Related]

  • 14. B3(Fv)-PE38KDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in mice.
    Brinkmann U, Pai LH, FitzGerald DJ, Willingham M, Pastan I.
    Proc Natl Acad Sci U S A; 1991 Oct 01; 88(19):8616-20. PubMed ID: 1924323
    [Abstract] [Full Text] [Related]

  • 15. Novel anti-CD30 recombinant immunotoxins containing disulfide-stabilized Fv fragments.
    Nagata S, Onda M, Numata Y, Santora K, Beers R, Kreitman RJ, Pastan I.
    Clin Cancer Res; 2002 Jul 01; 8(7):2345-55. PubMed ID: 12114439
    [Abstract] [Full Text] [Related]

  • 16. Recombinant single-chain and disulfide-stabilized Fv-immunotoxins that cause complete regression of a human colon cancer xenograft in nude mice.
    Reiter Y, Wright AF, Tonge DW, Pastan I.
    Int J Cancer; 1996 Jul 03; 67(1):113-23. PubMed ID: 8690511
    [Abstract] [Full Text] [Related]

  • 17. Cytotoxic and antitumor activity of a recombinant immunotoxin composed of disulfide-stabilized anti-Tac Fv fragment and truncated Pseudomonas exotoxin.
    Reiter Y, Kreitman RJ, Brinkmann U, Pastan I.
    Int J Cancer; 1994 Jul 01; 58(1):142-9. PubMed ID: 8014011
    [Abstract] [Full Text] [Related]

  • 18. Cloning, expression and characterization of the Fv fragments of the anti-carbohydrate mAbs B1 and B5 as single-chain immunotoxins.
    Benhar I, Pastan I.
    Protein Eng; 1994 Dec 01; 7(12):1509-15. PubMed ID: 7716163
    [Abstract] [Full Text] [Related]

  • 19. Improved binding and antitumor activity of a recombinant anti-erbB2 immunotoxin by disulfide stabilization of the Fv fragment.
    Reiter Y, Brinkmann U, Jung SH, Lee B, Kasprzyk PG, King CR, Pastan I.
    J Biol Chem; 1994 Jul 15; 269(28):18327-31. PubMed ID: 7913461
    [Abstract] [Full Text] [Related]

  • 20. Independent domain folding of Pseudomonas exotoxin and single-chain immunotoxins: influence of interdomain connections.
    Brinkmann U, Buchner J, Pastan I.
    Proc Natl Acad Sci U S A; 1992 Apr 01; 89(7):3075-9. PubMed ID: 1557415
    [Abstract] [Full Text] [Related]

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