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337 related items for PubMed ID: 8070328

  • 1. N-hydroxylation of the antiprotozoal drug pentamidine catalyzed by rabbit liver cytochrome P-450 2C3 or human liver microsomes, microsomal retroreduction, and further oxidative transformation of the formed amidoximes. Possible relationship to the biological oxidation of arginine to NG-hydroxyarginine, citrulline, and nitric oxide.
    Clement B, Jung F.
    Drug Metab Dispos; 1994; 22(3):486-97. PubMed ID: 8070328
    [Abstract] [Full Text] [Related]

  • 2. Cytochrome P450 dependent N-hydroxylation of a guanidine (debrisoquine), microsomal catalysed reduction and further oxidation of the N-hydroxy-guanidine metabolite to the urea derivative. Similarity with the oxidation of arginine to citrulline and nitric oxide.
    Clement B, Schultze-Mosgau MH, Wohlers H.
    Biochem Pharmacol; 1993 Dec 14; 46(12):2249-67. PubMed ID: 8274159
    [Abstract] [Full Text] [Related]

  • 3. N(delta)-Methylated L-arginine derivatives and their effects on the nitric oxide generating system.
    Kotthaus J, Schade D, Töpker-Lehmann K, Beitz E, Clement B.
    Bioorg Med Chem; 2008 Mar 01; 16(5):2305-12. PubMed ID: 18083522
    [Abstract] [Full Text] [Related]

  • 4. Microsomal cytochrome P450 dependent oxidation of N-hydroxyguanidines, amidoximes, and ketoximes: mechanism of the oxidative cleavage of their C=N(OH) bond with formation of nitrogen oxides.
    Jousserandot A, Boucher JL, Henry Y, Niklaus B, Clement B, Mansuy D.
    Biochemistry; 1998 Dec 08; 37(49):17179-91. PubMed ID: 9860831
    [Abstract] [Full Text] [Related]

  • 5. Cytochrome P450-dependent N-hydroxylation of an aminoguanidine (amidinohydrazone) and microsomal retroreduction of the N-hydroxylated product.
    Clement B, Schultze-Mosgau MH, Richter PH, Besch A.
    Xenobiotica; 1994 Jul 08; 24(7):671-88. PubMed ID: 7975731
    [Abstract] [Full Text] [Related]

  • 6. Roles of cytochrome b5 in the oxidation of testosterone and nifedipine by recombinant cytochrome P450 3A4 and by human liver microsomes.
    Yamazaki H, Nakano M, Imai Y, Ueng YF, Guengerich FP, Shimada T.
    Arch Biochem Biophys; 1996 Jan 15; 325(2):174-82. PubMed ID: 8561495
    [Abstract] [Full Text] [Related]

  • 7. N-hydroxylation and N-dealkylation by P4502C3 of N-methylbenzamidine: N-oxygenation and N-oxidative dealkylation of one functional group.
    Clement B, Jung F.
    Xenobiotica; 1995 May 15; 25(5):443-55. PubMed ID: 7571718
    [Abstract] [Full Text] [Related]

  • 8. Microsomal catalyzed N-hydroxylation of guanabenz and reduction of the N-hydroxylated metabolite: characterization of the two reactions and genotoxic potential of guanoxabenz.
    Clement B, Demesmaeker M, Linne S.
    Chem Res Toxicol; 1996 Jun 15; 9(4):682-8. PubMed ID: 8831810
    [Abstract] [Full Text] [Related]

  • 9. Metabolism of the antimammary cancer antiestrogenic agent tamoxifen. I. Cytochrome P-450-catalyzed N-demethylation and 4-hydroxylation.
    Mani C, Gelboin HV, Park SS, Pearce R, Parkinson A, Kupfer D.
    Drug Metab Dispos; 1993 Jun 15; 21(4):645-56. PubMed ID: 8104124
    [Abstract] [Full Text] [Related]

  • 10. Hydroxylation of pentamidine by rat liver microsomes.
    Berger BJ, Reddy VV, Le ST, Lombardy RJ, Hall JE, Tidwell RR.
    J Pharmacol Exp Ther; 1991 Mar 15; 256(3):883-9. PubMed ID: 2005586
    [Abstract] [Full Text] [Related]

  • 11. Particular ability of liver P450s3A to catalyze the oxidation of N omega-hydroxyarginine to citrulline and nitrogen oxides and occurrence in no synthases of a sequence very similar to the heme-binding sequence in P450s.
    Renaud JP, Boucher JL, Vadon S, Delaforge M, Mansuy D.
    Biochem Biophys Res Commun; 1993 Apr 15; 192(1):53-60. PubMed ID: 7682811
    [Abstract] [Full Text] [Related]

  • 12. Metabolism of N-nitroso-2,6-dimethylmorpholine by isozymes of rabbit liver microsomal cytochrome P-450.
    Kokkinakis DM, Koop DR, Scarpelli DG, Coon MJ, Hollenberg PF.
    Cancer Res; 1985 Feb 15; 45(2):619-24. PubMed ID: 3967237
    [Abstract] [Full Text] [Related]

  • 13. Metabolism of all-trans, 9-cis, and 13-cis isomers of retinal by purified isozymes of microsomal cytochrome P450 and mechanism-based inhibition of retinoid oxidation by citral.
    Raner GM, Vaz AD, Coon MJ.
    Mol Pharmacol; 1996 Mar 15; 49(3):515-22. PubMed ID: 8643091
    [Abstract] [Full Text] [Related]

  • 14. Oxidation of quinidine by human liver cytochrome P-450.
    Guengerich FP, Müller-Enoch D, Blair IA.
    Mol Pharmacol; 1986 Sep 15; 30(3):287-95. PubMed ID: 3748010
    [Abstract] [Full Text] [Related]

  • 15. Oxidation of 1,8-cineole, the monoterpene cyclic ether originated from eucalyptus polybractea, by cytochrome P450 3A enzymes in rat and human liver microsomes.
    Miyazawa M, Shindo M, Shimada T.
    Drug Metab Dispos; 2001 Feb 15; 29(2):200-5. PubMed ID: 11159812
    [Abstract] [Full Text] [Related]

  • 16. Reconstitution of rabbit liver microsomal N-nitrosopyrrolidine alpha-hydroxylase activity.
    McCoy GD, Koop DR.
    Cancer Res; 1988 Jul 15; 48(14):3987-92. PubMed ID: 3383193
    [Abstract] [Full Text] [Related]

  • 17. Oxygen-insensitive enzymatic reduction of oximes to imines.
    Heberling S, Girreser U, Wolf S, Clement B.
    Biochem Pharmacol; 2006 Jan 12; 71(3):354-65. PubMed ID: 16324684
    [Abstract] [Full Text] [Related]

  • 18. Purification and characterization of recombinant-expressed cytochrome P450 2C3 from Escherichia coli: 2C3 encodes the 6 beta-hydroxylase deficient form of P450 3b.
    Richardson TH, Hsu MH, Kronbach T, Barnes HJ, Chan G, Waterman MR, Kemper B, Johnson EF.
    Arch Biochem Biophys; 1993 Jan 12; 300(1):510-6. PubMed ID: 8380971
    [Abstract] [Full Text] [Related]

  • 19. Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation.
    Yun CH, Okerholm RA, Guengerich FP.
    Drug Metab Dispos; 1993 Jan 12; 21(3):403-9. PubMed ID: 8100494
    [Abstract] [Full Text] [Related]

  • 20. Analysis of neuronal NO synthase under single-turnover conditions: conversion of Nomega-hydroxyarginine to nitric oxide and citrulline.
    Abu-Soud HM, Presta A, Mayer B, Stuehr DJ.
    Biochemistry; 1997 Sep 09; 36(36):10811-6. PubMed ID: 9312270
    [Abstract] [Full Text] [Related]

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