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115 related items for PubMed ID: 8072378

  • 1. Microdialysis sampling in tumor and muscle: study of the disposition of 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide (SR 4233).
    Palsmeier RK, Lunte CE.
    Life Sci; 1994; 55(10):815-25. PubMed ID: 8072378
    [Abstract] [Full Text] [Related]

  • 2. Pharmacokinetics and bioreductive metabolism of the novel benzotriazine di-N-oxide hypoxic cell cytotoxin tirapazamine (WIN 59075; SR 4233; NSC 130181) in mice.
    Walton MI, Workman P.
    J Pharmacol Exp Ther; 1993 May; 265(2):938-47. PubMed ID: 8496834
    [Abstract] [Full Text] [Related]

  • 3. Microdialysis sampling with on-line microbore HPLC for the determination of tirapazamine and its reduced metabolites in rats.
    McLaughlin KJ, Faibushevich AA, Lunte CE.
    Analyst; 2000 Jan; 125(1):105-10. PubMed ID: 10885067
    [Abstract] [Full Text] [Related]

  • 4. Pharmacokinetics of the hypoxic cell cytotoxic agent tirapazamine and its major bioreductive metabolites in mice and humans: retrospective analysis of a pharmacokinetically guided dose-escalation strategy in a phase I trial.
    Graham MA, Senan S, Robin H, Eckhardt N, Lendrem D, Hincks J, Greenslade D, Rampling R, Kaye SB, von Roemeling R, Workman P.
    Cancer Chemother Pharmacol; 1997 Jan; 40(1):1-10. PubMed ID: 9137522
    [Abstract] [Full Text] [Related]

  • 5. Second-generation 1,2,4-benzotriazine 1,4-di-N-oxide bioreductive anti-tumor agents: pharmacology and activity in vitro and in vivo.
    Minchinton AI, Lemmon MJ, Tracy M, Pollart DJ, Martinez AP, Tosto LM, Brown JM.
    Int J Radiat Oncol Biol Phys; 1992 Jan; 22(4):701-5. PubMed ID: 1544841
    [Abstract] [Full Text] [Related]

  • 6. 3-amino-1,2,4-benzotriazine 4-oxide: characterization of a new metabolite arising from bioreductive processing of the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
    Fuchs T, Chowdhury G, Barnes CL, Gates KS.
    J Org Chem; 2001 Jan 12; 66(1):107-14. PubMed ID: 11429885
    [Abstract] [Full Text] [Related]

  • 7. Measurement of delivery and metabolism of tirapazamine to tumour tissue using the multilayered cell culture model.
    Kyle AH, Minchinton AI.
    Cancer Chemother Pharmacol; 1999 Jan 12; 43(3):213-20. PubMed ID: 9923551
    [Abstract] [Full Text] [Related]

  • 8. Phase I and pharmacokinetic study of tirapazamine (SR 4233) administered every three weeks.
    Senan S, Rampling R, Graham MA, Wilson P, Robin H, Eckardt N, Lawson N, McDonald A, von Roemeling R, Workman P, Kaye SB.
    Clin Cancer Res; 1997 Jan 12; 3(1):31-8. PubMed ID: 9815534
    [Abstract] [Full Text] [Related]

  • 9. Development and validation of a sensitive solid-phase-extraction and high-performance liquid chromatography assay for the bioreductive agent tirapazamine and its major metabolites in mouse and human plasma for pharmacokinetically guided dose escalation.
    Robin H, Senan S, Workman P, Graham MA.
    Cancer Chemother Pharmacol; 1995 Jan 12; 36(3):266-70. PubMed ID: 7781150
    [Abstract] [Full Text] [Related]

  • 10. Initial characterization of the major mouse cytochrome P450 enzymes involved in the reductive metabolism of the hypoxic cytotoxin 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide (tirapazamine, SR 4233, WIN 59075).
    Riley RJ, Hemingway SA, Graham MA, Workman P.
    Biochem Pharmacol; 1993 Mar 09; 45(5):1065-77. PubMed ID: 8461036
    [Abstract] [Full Text] [Related]

  • 11. Use of microdialysis to study platinum anticancer agent pharmacokinetics in preclinical models.
    Johansen MJ, Thapar N, Newman RA, Madden T.
    J Exp Ther Oncol; 2002 Mar 09; 2(3):163-73. PubMed ID: 12415633
    [Abstract] [Full Text] [Related]

  • 12. On-line coupling of in vivo microdialysis sampling with capillary electrophoresis.
    Hogan BL, Lunte SM, Stobaugh JF, Lunte CE.
    Anal Chem; 1994 Mar 01; 66(5):596-602. PubMed ID: 8154588
    [Abstract] [Full Text] [Related]

  • 13. Enzymology of the reductive bioactivation of SR 4233. A novel benzotriazine di-N-oxide hypoxic cell cytotoxin.
    Walton MI, Workman P.
    Biochem Pharmacol; 1990 Jun 01; 39(11):1735-42. PubMed ID: 2344370
    [Abstract] [Full Text] [Related]

  • 14. SR 4233 (tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours.
    Brown JM.
    Br J Cancer; 1993 Jun 01; 67(6):1163-70. PubMed ID: 8512801
    [Abstract] [Full Text] [Related]

  • 15. Intravenous microdialysis sampling in awake, freely-moving rats.
    Telting-Diaz M, Scott DO, Lunte CE.
    Anal Chem; 1992 Apr 01; 64(7):806-10. PubMed ID: 1524225
    [Abstract] [Full Text] [Related]

  • 16. Reduction of 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide (tirapazamine, WIN 59075, SR 4233) to a DNA-damaging species: a direct role for NADPH:cytochrome P450 oxidoreductase.
    Fitzsimmons SA, Lewis AD, Riley RJ, Workman P.
    Carcinogenesis; 1994 Aug 01; 15(8):1503-10. PubMed ID: 8055626
    [Abstract] [Full Text] [Related]

  • 17. Genotoxic effects of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) and nitrogen mustard-N-oxide (nitromin) in Walker carcinoma cells under aerobic and hypoxic conditions.
    Cahill A, Jenkins TC, Pickering P, White IN.
    Chem Biol Interact; 1995 Mar 30; 95(1-2):97-107. PubMed ID: 7697757
    [Abstract] [Full Text] [Related]

  • 18. The role of cytochrome P450 and cytochrome P450 reductase in the reductive bioactivation of the novel benzotriazine di-N-oxide hypoxic cytotoxin 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233, WIN 59075) by mouse liver.
    Walton MI, Wolf CR, Workman P.
    Biochem Pharmacol; 1992 Jul 22; 44(2):251-9. PubMed ID: 1642640
    [Abstract] [Full Text] [Related]

  • 19. Dual-electrode amperometric detection for the determination of SR4233 and its metabolites with microbore liquid chromatography.
    Liang XZ, Palsmeier RK, Lunte CE.
    J Pharm Biomed Anal; 1995 Dec 22; 14(1-2):113-9. PubMed ID: 8833973
    [Abstract] [Full Text] [Related]

  • 20. Reductive metabolism of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) and the induction of unscheduled DNA synthesis in rat and human derived cell lines.
    Cahill A, White IN.
    Carcinogenesis; 1990 Aug 22; 11(8):1407-11. PubMed ID: 2117504
    [Abstract] [Full Text] [Related]

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