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Journal Abstract Search

126 related items for PubMed ID: 8145222

  • 1. Synthesis and antibacterial activity of new quinolones containing a 7-[3-(1-amino-1-methylethyl)-1-pyrrolidinyl] moiety. Gram-positive agents with excellent oral activity and low side-effect potential.
    Hagen SE, Domagala JM, Gracheck SJ, Sesnie JA, Stier MA, Suto MJ.
    J Med Chem; 1994 Mar 18; 37(6):733-8. PubMed ID: 8145222
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  • 2. Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1- pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy.
    Domagala JM, Hagen SE, Joannides T, Kiely JS, Laborde E, Schroeder MC, Sesnie JA, Shapiro MA, Suto MJ, Vanderroest S.
    J Med Chem; 1993 Apr 02; 36(7):871-82. PubMed ID: 8385225
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  • 3. Studies on quinolone antibacterials. IV. Structure-activity relationships of antibacterial activity and side effects for 5- or 8-substituted and 5,8-disubstituted-7-(3-amino-1-pyrrolidinyl)-1-cyclopropyl-1, 4-dihydro-4-oxoquinoline-3-carboxylic acids.
    Yoshida T, Yamamoto Y, Orita H, Kakiuchi M, Takahashi Y, Itakura M, Kado N, Mitani K, Yasuda S, Kato H, Itoh Y.
    Chem Pharm Bull (Tokyo); 1996 May 02; 44(5):1074-85. PubMed ID: 8689718
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  • 5. Synthesis and antibacterial activity of novel 7-(3-substituted-3 or 4-trifluoromethyl-1-pyrrolidinyl)-8-methoxyfluoroquinolones.
    Fukui H, Shibata T, Naito T, Nakano J, Maejima T, Senda H, Iwatani W, Tatsumi Y, Suda M, Arika T.
    Bioorg Med Chem Lett; 1998 Oct 20; 8(20):2833-8. PubMed ID: 9873632
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  • 7. Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids.
    Hagen SE, Domagala JM, Heifetz CL, Johnson J.
    J Med Chem; 1991 Mar 20; 34(3):1155-61. PubMed ID: 2002456
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  • 10. Novel fluoroquinolone antibacterial agents containing oxime-substituted (aminomethyl)pyrrolidines: synthesis and antibacterial activity of 7-(4-(aminomethyl)-3-(methoxyimino)pyrrolidin-1-yl)-1-cyclopropyl-6- fluoro-4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylic acid (LB20304).
    Hong CY, Kim YK, Chang JH, Kim SH, Choi H, Nam DH, Kim YZ, Kwak JH.
    J Med Chem; 1997 Oct 24; 40(22):3584-93. PubMed ID: 9357525
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  • 11. Pyridonecarboxylic acids as antibacterial agents. VIII. Synthesis and structure-activity relationship of 7-(1-aminocyclopropyl)-4-oxo-1,8-naphthyridine-3-carboxylic acids and 7-(1-aminocyclopropyl)-4-oxoquinoline-3-carboxylic acids.
    Todo Y, Nitta J, Miyajima M, Fukuoka Y, Yamashiro Y, Nishida N, Saikawa I, Narita H.
    Chem Pharm Bull (Tokyo); 1994 Oct 24; 42(10):2063-70. PubMed ID: 7805131
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  • 12. The synthesis and antibacterial activities of quinolones containing five- and six-membered heterocyclic substituents at the 7-position.
    Cooper CS, Klock PL, Chu DT, Fernandes PB.
    J Med Chem; 1990 Apr 24; 33(4):1246-52. PubMed ID: 2319566
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  • 13. 7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an azetidine moiety.
    Frigola J, Torrens A, Castrillo JA, Mas J, Vañó D, Berrocal JM, Calvet C, Salgado L, Redondo J, García-Granda S.
    J Med Chem; 1994 Nov 25; 37(24):4195-210. PubMed ID: 7990118
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  • 15. 7-(2-Aminomethyl-1-azetidinyl)-4-oxoquinoline-3-carboxylic acids as potent antibacterial agents: design, synthesis, and antibacterial activity.
    Fujita M, Chiba K, Tominaga Y, Hino K.
    Chem Pharm Bull (Tokyo); 1998 May 25; 46(5):787-96. PubMed ID: 9621413
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  • 16. Synthesis and antimicrobial evaluation of a series of 7-[3-amino (or aminomethyl)-4-aryl (or cyclopropyl)-1-pyrrolidinyl]-4-quinolone- and -1,8-naphthyridone-3-carboxylic acids.
    Bucsh RA, Domagala JM, Laborde E, Sesnie JC.
    J Med Chem; 1993 Dec 24; 36(26):4139-51. PubMed ID: 8277495
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  • 20. 5-Amino-7-(3-amino-1-pyrrolidinyl)-1-cyclopropyl-6,8-difluoro-1,4- dihydro-4-oxo-3-quinolinecarboxylic acid (PD 124,816). Synthesis and biological evaluation of a new class of quinolone antibacterials.
    Domagala JM, Hagen SE, Hutt MP, Sanchez JP, Sesnie J, Trehan AK.
    Drugs Exp Clin Res; 1988 Dec 24; 14(7):453-60. PubMed ID: 2853667
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