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Journal Abstract Search

150 related items for PubMed ID: 8155660

  • 1. Structural determinants of cytochrome P450 2B1 specificity: evidence for five substrate recognition sites.
    He Y, Luo Z, Klekotka PA, Burnett VL, Halpert JR.
    Biochemistry; 1994 Apr 12; 33(14):4419-24. PubMed ID: 8155660
    [Abstract] [Full Text] [Related]

  • 2. Engineering of cytochrome P450 2B1 specificity. Conversion of an androgen 16 beta-hydroxylase to a 15 alpha-hydroxylase.
    Halpert JR, He YA.
    J Biol Chem; 1993 Feb 25; 268(6):4453-7. PubMed ID: 8440727
    [Abstract] [Full Text] [Related]

  • 3. Role of residues 363 and 206 in conversion of cytochrome P450 2B1 from a steroid 16-hydroxylase to a 15 alpha-hydroxylase.
    Luo Z, He YA, Halpert JR.
    Arch Biochem Biophys; 1994 Feb 15; 309(1):52-7. PubMed ID: 8117113
    [Abstract] [Full Text] [Related]

  • 4. Escherichia coli expression of site-directed mutants of cytochrome P450 2B1 from six substrate recognition sites: substrate specificity and inhibitor selectivity studies.
    He YQ, He YA, Halpert JR.
    Chem Res Toxicol; 1995 Jun 15; 8(4):574-9. PubMed ID: 7548737
    [Abstract] [Full Text] [Related]

  • 5. Role of residue 478 as a determinant of the substrate specificity of cytochrome P450 2B1.
    He YA, Balfour CA, Kedzie KM, Halpert JR.
    Biochemistry; 1992 Sep 29; 31(38):9220-6. PubMed ID: 1390709
    [Abstract] [Full Text] [Related]

  • 6. Reassessment of cytochrome P450 2B2: catalytic specificity and identification of four active site residues.
    Strobel SM, Halpert JR.
    Biochemistry; 1997 Sep 30; 36(39):11697-706. PubMed ID: 9305959
    [Abstract] [Full Text] [Related]

  • 7. Site-directed mutagenesis of putative substrate recognition sites in cytochrome P450 2B11: importance of amino acid residues 114, 290, and 363 for substrate specificity.
    Hasler JA, Harlow GR, Szklarz GD, John GH, Kedzie KM, Burnett VL, He YA, Kaminsky LS, Halpert JR.
    Mol Pharmacol; 1994 Aug 30; 46(2):338-45. PubMed ID: 8078495
    [Abstract] [Full Text] [Related]

  • 8. Structural determinants of progesterone hydroxylation by cytochrome P450 2B5: the role of nonsubstrate recognition site residues.
    He YQ, Harlow GR, Szklarz GD, Halpert JR.
    Arch Biochem Biophys; 1998 Feb 15; 350(2):333-9. PubMed ID: 9473309
    [Abstract] [Full Text] [Related]

  • 9. Role of residue 480 in substrate specificity of cytochrome P450 2B5 and 2B11.
    Liu J, He YA, Halpert JR.
    Arch Biochem Biophys; 1996 Mar 01; 327(1):167-73. PubMed ID: 8615687
    [Abstract] [Full Text] [Related]

  • 10. Interconversion of the androstenedione hydroxylase specificities of cytochromes P450 2B4 and 2B5 upon simultaneous site-directed mutagenesis of four key substrate recognition residues.
    He YQ, Szklarz GD, Halpert JR.
    Arch Biochem Biophys; 1996 Nov 01; 335(1):152-60. PubMed ID: 8914846
    [Abstract] [Full Text] [Related]

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  • 12. The lithocholic acid 6 beta-hydroxylase cytochrome P-450, CYP 3A10, is an active catalyst of steroid-hormone 6 beta-hydroxylation.
    Chang TK, Teixeira J, Gil G, Waxman DJ.
    Biochem J; 1993 Apr 15; 291 ( Pt 2)(Pt 2):429-33. PubMed ID: 8484723
    [Abstract] [Full Text] [Related]

  • 13. Alterations of the regiospecificity of progesterone metabolism by the mutagenesis of two key amino acid residues in rabbit cytochrome P450 2C3v.
    Richardson TH, Johnson EF.
    J Biol Chem; 1994 Sep 30; 269(39):23937-43. PubMed ID: 7929041
    [Abstract] [Full Text] [Related]

  • 14. Elucidation of amino acid residues critical for unique activities of rabbit cytochrome P450 2B5 using hybrid enzymes and reciprocal site-directed mutagenesis with rabbit cytochrome P450 2B4.
    Szklarz GD, He YQ, Kedzie KM, Halpert JR, Burnett VL.
    Arch Biochem Biophys; 1996 Mar 15; 327(2):308-18. PubMed ID: 8619620
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  • 16. Site-directed mutagenesis of mouse steroid 7 alpha-hydroxylase (cytochrome P-450(7) alpha): role of residue-209 in determining steroid-cytochrome P-450 interaction.
    Iwasaki M, Lindberg RL, Juvonen RO, Negishi M.
    Biochem J; 1993 Apr 15; 291 ( Pt 2)(Pt 2):569-73. PubMed ID: 8484736
    [Abstract] [Full Text] [Related]

  • 17. Role of the alanine at position 363 of cytochrome P450 2B2 in influencing the NADPH- and hydroperoxide-supported activities.
    Hanna IH, Teiber JF, Kokones KL, Hollenberg PF.
    Arch Biochem Biophys; 1998 Feb 15; 350(2):324-32. PubMed ID: 9473308
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  • 19. Identification of residues 286 and 289 as critical for conferring substrate specificity of human CYP2C9 for diclofenac and ibuprofen.
    Klose TS, Ibeanu GC, Ghanayem BI, Pedersen LG, Li L, Hall SD, Goldstein JA.
    Arch Biochem Biophys; 1998 Sep 15; 357(2):240-8. PubMed ID: 9735164
    [Abstract] [Full Text] [Related]

  • 20. Activation of the anticancer prodrugs cyclophosphamide and ifosfamide: identification of cytochrome P450 2B enzymes and site-specific mutants with improved enzyme kinetics.
    Chen CS, Lin JT, Goss KA, He YA, Halpert JR, Waxman DJ.
    Mol Pharmacol; 2004 May 15; 65(5):1278-85. PubMed ID: 15102956
    [Abstract] [Full Text] [Related]

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