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PUBMED FOR HANDHELDS

Journal Abstract Search


268 related items for PubMed ID: 8161350

  • 1. Saturation mutagenesis at dihydrofolate reductase codons 22 and 31. A variety of amino acid substitutions conferring methotrexate resistance.
    Morris JA, McIvor RS.
    Biochem Pharmacol; 1994 Mar 29; 47(7):1207-20. PubMed ID: 8161350
    [Abstract] [Full Text] [Related]

  • 2. Isolation and characterization of a variant dihydrofolate reductase cDNA from methotrexate-resistant murine L5178Y cells.
    McIvor RS, Simonsen CC.
    Nucleic Acids Res; 1990 Dec 11; 18(23):7025-32. PubMed ID: 2263462
    [Abstract] [Full Text] [Related]

  • 3. Transfection with a cDNA encoding a Ser31 or Ser34 mutant human dihydrofolate reductase into Chinese hamster ovary and mouse marrow progenitor cells confers methotrexate resistance.
    Banerjee D, Schweitzer BI, Volkenandt M, Li MX, Waltham M, Mineishi S, Zhao SC, Bertino JR.
    Gene; 1994 Feb 25; 139(2):269-74. PubMed ID: 8112617
    [Abstract] [Full Text] [Related]

  • 4. Transfection of a nonactive site mutant murine DHFR cDNA (the tryptophan 15 mutant) into Chinese hamster ovary and mouse marrow progenitor cells imparts MTX resistance in vitro.
    Banerjee D, Zhao SC, Tong Y, Steinherz J, Gritsman K, Bertino JR.
    Cancer Gene Ther; 1994 Sep 25; 1(3):181-4. PubMed ID: 7621249
    [Abstract] [Full Text] [Related]

  • 5. Transfection of DHFR- and DHFR+ mammalian cells using methotrexate-resistant mutants of mouse dihydrofolate reductase.
    Thillet J, Pictet R.
    FEBS Lett; 1990 Sep 03; 269(2):450-3. PubMed ID: 2401371
    [Abstract] [Full Text] [Related]

  • 6. Allelic variation in the dihydrofolate reductase gene at amino acid position 95 contributes to antifolate resistance in Chinese hamster cells.
    Yu M, Melera PW.
    Cancer Res; 1993 Dec 15; 53(24):6031-5. PubMed ID: 8261418
    [Abstract] [Full Text] [Related]

  • 7. A single point mutation in Drosophila dihydrofolate reductase confers methotrexate resistance to a transgenic CHO cell line.
    Neumann K, Al-Batayneh KM, Kuiper MJ, Parsons-Sheldrake J, Tyshenko MG, Flintoff WF, Cole SP, Walker VK.
    Genome; 2003 Aug 15; 46(4):707-15. PubMed ID: 12897877
    [Abstract] [Full Text] [Related]

  • 8. Drug-resistant dihydrofolate reductases: generation, expression and therapeutic application.
    McIvor RS.
    Bone Marrow Transplant; 1996 Dec 15; 18 Suppl 3():S50-4. PubMed ID: 8971409
    [Abstract] [Full Text] [Related]

  • 9. Selection for the expression of one form of Chinese hamster dihydrofolate reductase over another during growth in methotrexate.
    Hussain A, Yang H, Protzman J, Melera PW.
    Gene; 1994 Jul 08; 144(2):277-82. PubMed ID: 8039714
    [Abstract] [Full Text] [Related]

  • 10. Plasmid amplification-promoting sequences from the origin region of Chinese hamster dihydrofolate reductase gene do not promote position-independent chromosomal gene amplification.
    Brinton BT, Heintz NH.
    Chromosoma; 1995 Nov 08; 104(2):143-51. PubMed ID: 8585992
    [Abstract] [Full Text] [Related]

  • 11. Mutations in the gene for human dihydrofolate reductase: an unlikely cause of clinical relapse in pediatric leukemia after therapy with methotrexate.
    Spencer HT, Sorrentino BP, Pui CH, Chunduru SK, Sleep SE, Blakley RL.
    Leukemia; 1996 Mar 08; 10(3):439-46. PubMed ID: 8642859
    [Abstract] [Full Text] [Related]

  • 12. Construction of a dominant selectable marker using a novel dihydrofolate reductase.
    Hussain A, Lewis D, Yu M, Melera PW.
    Gene; 1992 Mar 15; 112(2):179-88. PubMed ID: 1555767
    [Abstract] [Full Text] [Related]

  • 13. An amplified insect dihydrofolate reductase gene contains a single intron.
    Shotkoski FA, Fallon AM.
    Eur J Biochem; 1991 Oct 01; 201(1):157-60. PubMed ID: 1915358
    [Abstract] [Full Text] [Related]

  • 14. Selection for methotrexate resistance in mammalian cells bearing a Drosophila dihydrofolate reductase transgene: Methotrexate resistance in transgenic mammalian cells.
    Affleck JG, Nowickyj SM, Walker VK.
    Cell Biol Toxicol; 2010 Apr 01; 26(2):117-26. PubMed ID: 19337845
    [Abstract] [Full Text] [Related]

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  • 17. Increasing methotrexate resistance by combination of active-site mutations in human dihydrofolate reductase.
    Volpato JP, Fossati E, Pelletier JN.
    J Mol Biol; 2007 Oct 26; 373(3):599-611. PubMed ID: 17868689
    [Abstract] [Full Text] [Related]

  • 18. Assay for expression of methotrexate-resistant dihydrofolate reductase activity in the presence of drug-sensitive enzyme.
    Thompson K, Vinh DB, McIvor RS.
    J Pharmacol Toxicol Methods; 1992 Nov 26; 28(3):167-73. PubMed ID: 1489988
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  • 20. A comparison of the propensity for gene amplification between near-tetraploid and near-diploid V79 clones resistant to 150 nM methotrexate.
    Hashimoto MW, Nikaido O, Kobayashi N, Chang CC, Trosko JE, Mori T.
    Carcinogenesis; 1996 Mar 26; 17(3):389-94. PubMed ID: 8631121
    [Abstract] [Full Text] [Related]


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