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Journal Abstract Search

531 related items for PubMed ID: 8215458

  • 1. Hydrophobic side chain requirements for lauric acid and progesterone hydroxylation at amino acid 113 in cytochrome P450 2C2, a potential determinant of substrate specificity.
    Straub P, Johnson EF, Kemper B.
    Arch Biochem Biophys; 1993 Nov 01; 306(2):521-7. PubMed ID: 8215458
    [Abstract] [Full Text] [Related]

  • 2. Differential effects of mutations in substrate recognition site 1 of cytochrome P450 2C2 on lauric acid and progesterone hydroxylation.
    Straub P, Lloyd M, Johnson EF, Kemper B.
    Biochemistry; 1994 Jul 05; 33(26):8029-34. PubMed ID: 8025107
    [Abstract] [Full Text] [Related]

  • 3. Identification by in vitro mutagenesis of the interaction of two segments of C2MstC1, a chimera of cytochromes P450 2C2 and P450 2C1.
    Ramarao MK, Straub P, Kemper B.
    J Biol Chem; 1995 Jan 27; 270(4):1873-80. PubMed ID: 7829524
    [Abstract] [Full Text] [Related]

  • 4. Substitution at residue 473 confers progesterone 21-hydroxylase activity to cytochrome P450 2C2.
    Ramarao M, Kemper B.
    Mol Pharmacol; 1995 Sep 27; 48(3):417-24. PubMed ID: 7565621
    [Abstract] [Full Text] [Related]

  • 5. Identification of three key residues in substrate recognition site 5 of human cytochrome P450 3A4 by cassette and site-directed mutagenesis.
    He YA, He YQ, Szklarz GD, Halpert JR.
    Biochemistry; 1997 Jul 22; 36(29):8831-9. PubMed ID: 9220969
    [Abstract] [Full Text] [Related]

  • 6. Enzymatic determinants of the substrate specificity of CYP2C9: role of B'-C loop residues in providing the pi-stacking anchor site for warfarin binding.
    Haining RL, Jones JP, Henne KR, Fisher MB, Koop DR, Trager WF, Rettie AE.
    Biochemistry; 1999 Mar 16; 38(11):3285-92. PubMed ID: 10079071
    [Abstract] [Full Text] [Related]

  • 7. Analysis of four residues within substrate recognition site 4 of human cytochrome P450 3A4: role in steroid hydroxylase activity and alpha-naphthoflavone stimulation.
    Domanski TL, Liu J, Harlow GR, Halpert JR.
    Arch Biochem Biophys; 1998 Feb 15; 350(2):223-32. PubMed ID: 9473295
    [Abstract] [Full Text] [Related]

  • 8. Identification of rabbit cytochromes P450 2C1 and 2C2 as arachidonic acid epoxygenases.
    Laethem RM, Koop DR.
    Mol Pharmacol; 1992 Dec 15; 42(6):958-63. PubMed ID: 1480136
    [Abstract] [Full Text] [Related]

  • 9. Site-directed mutagenesis of the putative distal helix of peroxygenase cytochrome P450.
    Matsunaga I, Ueda A, Sumimoto T, Ichihara K, Ayata M, Ogura H.
    Arch Biochem Biophys; 2001 Oct 01; 394(1):45-53. PubMed ID: 11566026
    [Abstract] [Full Text] [Related]

  • 10. Elucidation of amino acid residues critical for unique activities of rabbit cytochrome P450 2B5 using hybrid enzymes and reciprocal site-directed mutagenesis with rabbit cytochrome P450 2B4.
    Szklarz GD, He YQ, Kedzie KM, Halpert JR, Burnett VL.
    Arch Biochem Biophys; 1996 Mar 15; 327(2):308-18. PubMed ID: 8619620
    [Abstract] [Full Text] [Related]

  • 11. Interconversion of the androstenedione hydroxylase specificities of cytochromes P450 2B4 and 2B5 upon simultaneous site-directed mutagenesis of four key substrate recognition residues.
    He YQ, Szklarz GD, Halpert JR.
    Arch Biochem Biophys; 1996 Nov 01; 335(1):152-60. PubMed ID: 8914846
    [Abstract] [Full Text] [Related]

  • 12. Cassette mutagenesis of a potential substrate recognition region of cytochrome P450 2C2.
    Straub P, Lloyd M, Johnson EF, Kemper B.
    J Biol Chem; 1993 Oct 15; 268(29):21997-2003. PubMed ID: 8408056
    [Abstract] [Full Text] [Related]

  • 13. Dual role of human cytochrome P450 3A4 residue Phe-304 in substrate specificity and cooperativity.
    Domanski TL, He YA, Harlow GR, Halpert JR.
    J Pharmacol Exp Ther; 2000 May 15; 293(2):585-91. PubMed ID: 10773032
    [Abstract] [Full Text] [Related]

  • 14. Role of residue 480 in substrate specificity of cytochrome P450 2B5 and 2B11.
    Liu J, He YA, Halpert JR.
    Arch Biochem Biophys; 1996 Mar 01; 327(1):167-73. PubMed ID: 8615687
    [Abstract] [Full Text] [Related]

  • 15. A conserved proline-rich sequence between the N-terminal signal-anchor and catalytic domains is required for assembly of functional cytochrome P450 2C2.
    Chen CD, Doray B, Kemper B.
    Arch Biochem Biophys; 1998 Feb 15; 350(2):233-8. PubMed ID: 9473296
    [Abstract] [Full Text] [Related]

  • 16. Preference for aromatic substitutions at tryptophan-120, which is highly conserved and a potential mediator of electron transfer in cytochrome P450 2C2.
    Straub P, Ramarao MK, Kemper B.
    Biochem Biophys Res Commun; 1993 Dec 15; 197(2):433-9. PubMed ID: 8267578
    [Abstract] [Full Text] [Related]

  • 17. Alterations of the regiospecificity of progesterone metabolism by the mutagenesis of two key amino acid residues in rabbit cytochrome P450 2C3v.
    Richardson TH, Johnson EF.
    J Biol Chem; 1994 Sep 30; 269(39):23937-43. PubMed ID: 7929041
    [Abstract] [Full Text] [Related]

  • 18. Nonsubstrate recognition site residues are involved in testosterone hydroxylation by cytochrome P450 CYP 2C11.
    Biagini CP, Philpot RM, Célier CM.
    Arch Biochem Biophys; 1999 Jan 15; 361(2):309-14. PubMed ID: 9882461
    [Abstract] [Full Text] [Related]

  • 19. Importance of amino acid residue 474 for substrate specificity of canine and human cytochrome p450 3A enzymes.
    He YQ, Roussel F, Halpert JR.
    Arch Biochem Biophys; 2001 May 15; 389(2):264-70. PubMed ID: 11339816
    [Abstract] [Full Text] [Related]

  • 20. Purification and characterization of recombinant-expressed cytochrome P450 2C3 from Escherichia coli: 2C3 encodes the 6 beta-hydroxylase deficient form of P450 3b.
    Richardson TH, Hsu MH, Kronbach T, Barnes HJ, Chan G, Waterman MR, Kemper B, Johnson EF.
    Arch Biochem Biophys; 1993 Jan 15; 300(1):510-6. PubMed ID: 8380971
    [Abstract] [Full Text] [Related]

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