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Journal Abstract Search

386 related items for PubMed ID: 8242617

  • 1. Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes.
    Chang TK, Weber GF, Crespi CL, Waxman DJ.
    Cancer Res; 1993 Dec 01; 53(23):5629-37. PubMed ID: 8242617
    [Abstract] [Full Text] [Related]

  • 2. Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles.
    Roy P, Yu LJ, Crespi CL, Waxman DJ.
    Drug Metab Dispos; 1999 Jun 01; 27(6):655-66. PubMed ID: 10348794
    [Abstract] [Full Text] [Related]

  • 3. Role of cytochrome P450 in oxazaphosphorine metabolism. Deactivation via N-dechloroethylation and activation via 4-hydroxylation catalyzed by distinct subsets of rat liver cytochromes P450.
    Yu L, Waxman DJ.
    Drug Metab Dispos; 1996 Nov 01; 24(11):1254-62. PubMed ID: 8937861
    [Abstract] [Full Text] [Related]

  • 4. Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines.
    Chang TK, Yu L, Maurel P, Waxman DJ.
    Cancer Res; 1997 May 15; 57(10):1946-54. PubMed ID: 9157990
    [Abstract] [Full Text] [Related]

  • 5. Activation of the anti-cancer drug ifosphamide by rat liver microsomal P450 enzymes.
    Weber GF, Waxman DJ.
    Biochem Pharmacol; 1993 Apr 22; 45(8):1685-94. PubMed ID: 8484807
    [Abstract] [Full Text] [Related]

  • 6. Identification of human cytochrome P450 isoforms involved in the 3-hydroxylation of quinine by human live microsomes and nine recombinant human cytochromes P450.
    Zhao XJ, Yokoyama H, Chiba K, Wanwimolruk S, Ishizaki T.
    J Pharmacol Exp Ther; 1996 Dec 22; 279(3):1327-34. PubMed ID: 8968357
    [Abstract] [Full Text] [Related]

  • 7. Eight inhibitory monoclonal antibodies define the role of individual P-450s in human liver microsomal diazepam, 7-ethoxycoumarin, and imipramine metabolism.
    Yang TJ, Krausz KW, Sai Y, Gonzalez FJ, Gelboin HV.
    Drug Metab Dispos; 1999 Jan 22; 27(1):102-9. PubMed ID: 9884317
    [Abstract] [Full Text] [Related]

  • 8. Intratumoral activation and enhanced chemotherapeutic effect of oxazaphosphorines following cytochrome P-450 gene transfer: development of a combined chemotherapy/cancer gene therapy strategy.
    Chen L, Waxman DJ.
    Cancer Res; 1995 Feb 01; 55(3):581-9. PubMed ID: 7834628
    [Abstract] [Full Text] [Related]

  • 9. Roles of cytochromes P450 1A2 and 3A4 in the oxidation of estradiol and estrone in human liver microsomes.
    Yamazaki H, Shaw PM, Guengerich FP, Shimada T.
    Chem Res Toxicol; 1998 Jun 01; 11(6):659-65. PubMed ID: 9625734
    [Abstract] [Full Text] [Related]

  • 10. 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) modulates rat liver microsomal cyclophosphamide and ifosphamide activation by suppressing cytochrome P450 2C11 messenger RNA levels.
    Chang TK, Chen H, Waxman DJ.
    Drug Metab Dispos; 1994 Jun 01; 22(5):673-9. PubMed ID: 7835216
    [Abstract] [Full Text] [Related]

  • 11. Activation of amino-alpha-carboline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and a copper phthalocyanine cellulose extract of cigarette smoke condensate by cytochrome P-450 enzymes in rat and human liver microsomes.
    Shimada T, Guengerich FP.
    Cancer Res; 1991 Oct 01; 51(19):5284-91. PubMed ID: 1913651
    [Abstract] [Full Text] [Related]

  • 12. Cyclophosphamide modulates rat hepatic cytochrome P450 2C11 and steroid 5 alpha-reductase activity and messenger RNA levels through the combined action of acrolein and phosphoramide mustard.
    Chang TK, Waxman DJ.
    Cancer Res; 1993 Jun 01; 53(11):2490-7. PubMed ID: 8495410
    [Abstract] [Full Text] [Related]

  • 13. Catalytic role of cytochrome P4502B6 in the N-demethylation of S-mephenytoin.
    Heyn H, White RB, Stevens JC.
    Drug Metab Dispos; 1996 Sep 01; 24(9):948-54. PubMed ID: 8886603
    [Abstract] [Full Text] [Related]

  • 14. Both cytochromes P450 2E1 and 3A are involved in the O-hydroxylation of p-nitrophenol, a catalytic activity known to be specific for P450 2E1.
    Zerilli A, Ratanasavanh D, Lucas D, Goasduff T, Dréano Y, Menard C, Picart D, Berthou F.
    Chem Res Toxicol; 1997 Oct 01; 10(10):1205-12. PubMed ID: 9348445
    [Abstract] [Full Text] [Related]

  • 15. Identification of human cytochrome P450 isoforms involved in the stereoselective metabolism of mianserin enantiomers.
    Koyama E, Chiba K, Tani M, Ishizaki T.
    J Pharmacol Exp Ther; 1996 Jul 01; 278(1):21-30. PubMed ID: 8764331
    [Abstract] [Full Text] [Related]

  • 16. Prediction of human liver microsomal oxidations of 7-ethoxycoumarin and chlorzoxazone with kinetic parameters of recombinant cytochrome P-450 enzymes.
    Shimada T, Tsumura F, Yamazaki H.
    Drug Metab Dispos; 1999 Nov 01; 27(11):1274-80. PubMed ID: 10534312
    [Abstract] [Full Text] [Related]

  • 17. Role of human microsomal and human complementary DNA-expressed cytochromes P4501A2 and P4503A4 in the bioactivation of aflatoxin B1.
    Gallagher EP, Wienkers LC, Stapleton PL, Kunze KL, Eaton DL.
    Cancer Res; 1994 Jan 01; 54(1):101-8. PubMed ID: 8261428
    [Abstract] [Full Text] [Related]

  • 18. Major pathway of imipramine metabolism is catalyzed by cytochromes P-450 1A2 and P-450 3A4 in human liver.
    Lemoine A, Gautier JC, Azoulay D, Kiffel L, Belloc C, Guengerich FP, Maurel P, Beaune P, Leroux JP.
    Mol Pharmacol; 1993 May 01; 43(5):827-32. PubMed ID: 8502233
    [Abstract] [Full Text] [Related]

  • 19. CYP2D6 catalyzes tamoxifen 4-hydroxylation in human liver.
    Dehal SS, Kupfer D.
    Cancer Res; 1997 Aug 15; 57(16):3402-6. PubMed ID: 9270005
    [Abstract] [Full Text] [Related]

  • 20. Orphenadrine and methimazole inhibit multiple cytochrome P450 enzymes in human liver microsomes.
    Guo Z, Raeissi S, White RB, Stevens JC.
    Drug Metab Dispos; 1997 Mar 15; 25(3):390-3. PubMed ID: 9172960
    [Abstract] [Full Text] [Related]

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