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153 related items for PubMed ID: 8243474

  • 1. Phenotype of recombinant Leishmania donovani and Trypanosoma cruzi which over-express trypanothione reductase. Sensitivity towards agents that are thought to induce oxidative stress.
    Kelly JM, Taylor MC, Smith K, Hunter KJ, Fairlamb AH.
    Eur J Biochem; 1993 Nov 15; 218(1):29-37. PubMed ID: 8243474
    [Abstract] [Full Text] [Related]

  • 2. An approach to functional complementation by introduction of large DNA fragments into Trypanosoma cruzi and Leishmania donovani using a cosmid shuttle vector.
    Kelly JM, Das P, Tomás AM.
    Mol Biochem Parasitol; 1994 May 15; 65(1):51-62. PubMed ID: 7935628
    [Abstract] [Full Text] [Related]

  • 3. Down-regulation of Leishmania donovani trypanothione reductase by heterologous expression of a trans-dominant mutant homologue: effect on parasite intracellular survival.
    Tovar J, Cunningham ML, Smith AC, Croft SL, Fairlamb AH.
    Proc Natl Acad Sci U S A; 1998 Apr 28; 95(9):5311-6. PubMed ID: 9560272
    [Abstract] [Full Text] [Related]

  • 4. The structure, organization, and expression of the Leishmania donovani gene encoding trypanothione reductase.
    Taylor MC, Kelly JM, Chapman CJ, Fairlamb AH, Miles MA.
    Mol Biochem Parasitol; 1994 Apr 28; 64(2):293-301. PubMed ID: 7935607
    [Abstract] [Full Text] [Related]

  • 5. Inhibition of Trypanosoma cruzi trypanothione reductase by crystal violet.
    Moreno SN, Carnieri EG, Docampo R.
    Mol Biochem Parasitol; 1994 Oct 28; 67(2):313-20. PubMed ID: 7870135
    [Abstract] [Full Text] [Related]

  • 6. Ovothiol and trypanothione as antioxidants in trypanosomatids.
    Ariyanayagam MR, Fairlamb AH.
    Mol Biochem Parasitol; 2001 Jul 28; 115(2):189-98. PubMed ID: 11420105
    [Abstract] [Full Text] [Related]

  • 7. Site-directed mutagenesis of the redox-active cysteines of Trypanosoma cruzi trypanothione reductase.
    Borges A, Cunningham ML, Tovar J, Fairlamb AH.
    Eur J Biochem; 1995 Mar 15; 228(3):745-52. PubMed ID: 7737173
    [Abstract] [Full Text] [Related]

  • 8. Trypanothione reductase from Leishmania donovani. Purification, characterisation and inhibition by trivalent antimonials.
    Cunningham ML, Fairlamb AH.
    Eur J Biochem; 1995 Jun 01; 230(2):460-8. PubMed ID: 7607216
    [Abstract] [Full Text] [Related]

  • 9. Synthesis and evaluation of 9,9-dimethylxanthene tricyclics against trypanothione reductase, Trypanosoma brucei, Trypanosoma cruzi and Leishmania donovani.
    Chibale K, Visser M, Yardley V, Croft SL, Fairlamb AH.
    Bioorg Med Chem Lett; 2000 Jun 05; 10(11):1147-50. PubMed ID: 10866368
    [Abstract] [Full Text] [Related]

  • 10. Glutathione and the redox control system trypanothione/trypanothione reductase are involved in the protection of Leishmania spp. against nitrosothiol-induced cytotoxicity.
    Romão PR, Tovar J, Fonseca SG, Moraes RH, Cruz AK, Hothersall JS, Noronha-Dutra AA, Ferreira SH, Cunha FQ.
    Braz J Med Biol Res; 2006 Mar 05; 39(3):355-63. PubMed ID: 16501815
    [Abstract] [Full Text] [Related]

  • 11. The trypanothione reductase gene of Leishmania donovani.
    Taylor MC, Kelly JM, Fairlamb AH, Miles MA.
    Biochem Soc Trans; 1990 Oct 05; 18(5):869-70. PubMed ID: 2083703
    [No Abstract] [Full Text] [Related]

  • 12. Phenothiazine inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs.
    Chan C, Yin H, Garforth J, McKie JH, Jaouhari R, Speers P, Douglas KT, Rock PJ, Yardley V, Croft SL, Fairlamb AH.
    J Med Chem; 1998 Jan 15; 41(2):148-56. PubMed ID: 9457238
    [Abstract] [Full Text] [Related]

  • 13. Entamoeba histolytica lacks trypanothione metabolism.
    Ariyanayagam MR, Fairlamb AH.
    Mol Biochem Parasitol; 1999 Sep 20; 103(1):61-9. PubMed ID: 10514081
    [Abstract] [Full Text] [Related]

  • 14. Gamma-glutamylcysteine synthetase and tryparedoxin 1 exert high control on the antioxidant system in Trypanosoma cruzi contributing to drug resistance and infectivity.
    González-Chávez Z, Vázquez C, Mejia-Tlachi M, Márquez-Dueñas C, Manning-Cela R, Encalada R, Rodríguez-Enríquez S, Michels PAM, Moreno-Sánchez R, Saavedra E.
    Redox Biol; 2019 Sep 20; 26():101231. PubMed ID: 31203195
    [Abstract] [Full Text] [Related]

  • 15. Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages.
    Dumas C, Ouellette M, Tovar J, Cunningham ML, Fairlamb AH, Tamar S, Olivier M, Papadopoulou B.
    EMBO J; 1997 May 15; 16(10):2590-8. PubMed ID: 9184206
    [Abstract] [Full Text] [Related]

  • 16. Expression, purification, and characterization of Leishmania donovani trypanothione reductase in Escherichia coli.
    Mittal MK, Misra S, Owais M, Goyal N.
    Protein Expr Purif; 2005 Apr 15; 40(2):279-86. PubMed ID: 15766869
    [Abstract] [Full Text] [Related]

  • 17. Rational design of nitrofuran derivatives: Synthesis and valuation as inhibitors of Trypanosoma cruzi trypanothione reductase.
    Arias DG, Herrera FE, Garay AS, Rodrigues D, Forastieri PS, Luna LE, Bürgi MD, Prieto C, Iglesias AA, Cravero RM, Guerrero SA.
    Eur J Med Chem; 2017 Jan 05; 125():1088-1097. PubMed ID: 27810595
    [Abstract] [Full Text] [Related]

  • 18. Stage-dependent expression and up-regulation of trypanothione synthetase in amphotericin B resistant Leishmania donovani.
    Equbal A, Suman SS, Anwar S, Singh KP, Zaidi A, Sardar AH, Das P, Ali V.
    PLoS One; 2014 Jan 05; 9(6):e97600. PubMed ID: 24901644
    [Abstract] [Full Text] [Related]

  • 19. Peptoid inhibition of trypanothione reductase as a potential antitrypanosomal and antileishmanial drug lead.
    Chan C, Yin H, McKie JH, Fairlamb AH, Douglas KT.
    Amino Acids; 2002 Jun 05; 22(4):297-308. PubMed ID: 12107758
    [Abstract] [Full Text] [Related]

  • 20. Leishmania subtilisin is a maturase for the trypanothione reductase system and contributes to disease pathology.
    Swenerton RK, Knudsen GM, Sajid M, Kelly BL, McKerrow JH.
    J Biol Chem; 2010 Oct 08; 285(41):31120-9. PubMed ID: 20675366
    [Abstract] [Full Text] [Related]

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