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562 related items for PubMed ID: 8246174

  • 1. Selective expression of methotrexate-resistant dihydrofolate reductase (DHFR) activity in mice transduced with DHFR retrovirus and administered methotrexate.
    Vinh DB, McIvor RS.
    J Pharmacol Exp Ther; 1993 Nov; 267(2):989-96. PubMed ID: 8246174
    [Abstract] [Full Text] [Related]

  • 2. Comparison of methotrexate resistance conferred by a mutated dihydrofolate reductase (DHFR) cDNA in two different retroviral vectors.
    Takebe N, Nakahara S, Zhao SC, Adhikari D, Ural AU, Iwamoto M, Banerjee D, Bertino JR.
    Cancer Gene Ther; 2000 Jun; 7(6):910-9. PubMed ID: 10880023
    [Abstract] [Full Text] [Related]

  • 3. Generation of dual resistance to 4-hydroperoxycyclophosphamide and methotrexate by retroviral transfer of the human aldehyde dehydrogenase class 1 gene and a mutated dihydrofolate reductase gene.
    Takebe N, Zhao SC, Adhikari D, Mineishi S, Sadelain M, Hilton J, Colvin M, Banerjee D, Bertino JR.
    Mol Ther; 2001 Jan; 3(1):88-96. PubMed ID: 11162315
    [Abstract] [Full Text] [Related]

  • 4. Transgenic mice expressing the tyr22 variant of murine DHFR: protection of transgenic marrow transplant recipients from lethal doses of methotrexate.
    James RI, May C, Vagt MD, Studebaker R, McIvor RS.
    Exp Hematol; 1997 Nov; 25(12):1286-95. PubMed ID: 9357973
    [Abstract] [Full Text] [Related]

  • 5. Methotrexate accumulates to similar levels in animals transplanted with normal versus drug-resistant transgenic marrow.
    Belur LR, Boelk-Galvan D, Diers MD, McIvor RS, Zimmerman CL.
    Cancer Res; 2001 Feb 15; 61(4):1522-6. PubMed ID: 11245460
    [Abstract] [Full Text] [Related]

  • 6. Long-term protection of recipient mice from lethal doses of methotrexate by marrow infected with a double-copy vector retrovirus containing a mutant dihydrofolate reductase.
    Zhao SC, Li MX, Banerjee D, Schweitzer BI, Mineishi S, Gilboa E, Bertino JR.
    Cancer Gene Ther; 1994 Mar 15; 1(1):27-33. PubMed ID: 7621235
    [Abstract] [Full Text] [Related]

  • 7. Methotrexate preconditioning allows sufficient engraftment to confer drug resistance in mice transplanted with marrow expressing drug-resistant dihydrofolate reductase activity.
    Belur LR, James RI, May C, Diers MD, Swanson D, Gunther R, McIvor RS.
    J Pharmacol Exp Ther; 2005 Aug 15; 314(2):668-74. PubMed ID: 15857949
    [Abstract] [Full Text] [Related]

  • 8. Methotrexate selection of long-term culture initiating cells following transduction of CD34(+) cells with a retrovirus containing a mutated human dihydrofolate reductase gene.
    Takebe N, Xu LC, MacKenzie KL, Bertino JR, Moore MA.
    Cancer Gene Ther; 2002 Mar 15; 9(3):308-20. PubMed ID: 11896448
    [Abstract] [Full Text] [Related]

  • 9. [Mice transduced with double-mutant dihydrofolate reductase-cytidine deaminase fusion gene attained protection from high dose chemotherapy].
    Lu P, Lu Y, Pang K, Wang SB, Chen JQ, Xu HM, Wang JK, Zhao SC.
    Zhonghua Wai Ke Za Zhi; 2005 Aug 01; 43(15):998-1001. PubMed ID: 16194358
    [Abstract] [Full Text] [Related]

  • 10. Drug-resistant dihydrofolate reductases: generation, expression and therapeutic application.
    McIvor RS.
    Bone Marrow Transplant; 1996 Dec 01; 18 Suppl 3():S50-4. PubMed ID: 8971409
    [Abstract] [Full Text] [Related]

  • 11. Co-expression of the herpes simplex virus thymidine kinase gene potentiates methotrexate resistance conferred by transfer of a mutated dihydrofolate reductase gene.
    Mineishi S, Nakahara S, Takebe N, Banerjee D, Zhao SC, Bertino JR.
    Gene Ther; 1997 Jun 01; 4(6):570-6. PubMed ID: 9231073
    [Abstract] [Full Text] [Related]

  • 12. [Double-mutant dihydrofolate reductase gene transfection into bone marrow cells protects mice from chemotherapy].
    Gao HD, Lu P, Lu Y, Pang K, Xu HM, Wang SB, Chen JQ, Zhao SC.
    Zhonghua Zhong Liu Za Zhi; 2006 Aug 01; 28(8):583-5. PubMed ID: 17236551
    [Abstract] [Full Text] [Related]

  • 13. [Insertion of the bacterial gene for dihydrofolate reductase into colony-forming cells of mouse bone marrow].
    Titomirov AV, Pereverzev AE, Stepan'ian LI, Podgornaia OI, Aprelikova ON.
    Tsitologiia; 1985 Oct 01; 27(10):1183-8. PubMed ID: 3000033
    [Abstract] [Full Text] [Related]

  • 14. Protection of mice from methotrexate toxicity by ex vivo transduction using lentivirus vectors expressing drug-resistant dihydrofolate reductase.
    Gori JL, Podetz-Pedersen K, Swanson D, Karlen AD, Gunther R, Somia NV, McIvor RS.
    J Pharmacol Exp Ther; 2007 Sep 01; 322(3):989-97. PubMed ID: 17586722
    [Abstract] [Full Text] [Related]

  • 15. In vivo methotrexate selection of murine hemopoietic cells transduced with a retroviral vector for Gaucher disease.
    Havenga M, Valerio D, Hoogerbrugge P, Es H.
    Gene Ther; 1999 Oct 01; 6(10):1661-9. PubMed ID: 10516714
    [Abstract] [Full Text] [Related]

  • 16. Methotrexate resistance conferred by transplantation of drug-resistant transgenic marrow cells fractionated bycounterflow elutriation.
    James R, May C, Diers M, Wagner J, McIvor R.
    Bone Marrow Transplant; 1999 Oct 01; 24(8):815-21. PubMed ID: 10516690
    [Abstract] [Full Text] [Related]

  • 17. Methotrexate dose-escalation studies in transgenic mice and marrow transplant recipients expressing drug-resistant dihydrofolate reductase activity.
    May C, James RI, Gunther R, McIvor RS.
    J Pharmacol Exp Ther; 1996 Sep 01; 278(3):1444-51. PubMed ID: 8819532
    [Abstract] [Full Text] [Related]

  • 18. Retrovirally mediated gene transfer of Arg22 and Tyr22 forms of dihydrofolate reductase into the hematopoietic cell line K562: a comparison of methotrexate resistance.
    Braun SE, McIvor RS, Davidson AS, Hanna M, Traycoff CM, Berebetsky DA, Gonin R, Broxmeyer HE, Cornetta K.
    Cancer Gene Ther; 1997 Sep 01; 4(1):26-32. PubMed ID: 9012448
    [Abstract] [Full Text] [Related]

  • 19. Transfection of a nonactive site mutant murine DHFR cDNA (the tryptophan 15 mutant) into Chinese hamster ovary and mouse marrow progenitor cells imparts MTX resistance in vitro.
    Banerjee D, Zhao SC, Tong Y, Steinherz J, Gritsman K, Bertino JR.
    Cancer Gene Ther; 1994 Sep 01; 1(3):181-4. PubMed ID: 7621249
    [Abstract] [Full Text] [Related]

  • 20. Myeloproliferative sarcoma virus directed expression of beta-galactosidase following retroviral transduction of murine hematopoietic cells.
    Clapp DW, Freie B, Srour E, Yoder MC, Fortney K, Gerson SL.
    Exp Hematol; 1995 Jul 01; 23(7):630-8. PubMed ID: 7601255
    [Abstract] [Full Text] [Related]

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