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Journal Abstract Search

103 related items for PubMed ID: 8246244

  • 1. Synthesis and biological activity of some methoctramine-related tetraamines bearing a 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-one moiety as antimuscarinics: a second generation of highly selective M2 muscarinic receptor antagonists.
    Melchiorre C, Bolognesi ML, Chiarini A, Minarini A, Spampinato S.
    J Med Chem; 1993 Nov 12; 36(23):3734-7. PubMed ID: 8246244
    [No Abstract] [Full Text] [Related]

  • 2. Design, synthesis, and biological activity of methoctramine-related tetraamines bearing an 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4] benzodiazepin-6-one moiety: structural requirements for optimum occupancy of muscarinic receptor subtypes as revealed by symmetrical and unsymmetrical polyamines.
    Minarini A, Bolognesi ML, Budriesi R, Canossa M, Chiarini A, Spampinato S, Melchiorre C.
    J Med Chem; 1994 Sep 30; 37(20):3363-72. PubMed ID: 7932564
    [Abstract] [Full Text] [Related]

  • 3. The design of novel methoctramine-related tetraamines as muscarinic receptor subtype selective antagonists.
    Melchiorre C, Minarini A, Budriesi R, Chiarini A, Spampinato S, Tumiatti V.
    Life Sci; 1995 Sep 30; 56(11-12):837-44. PubMed ID: 10188783
    [Abstract] [Full Text] [Related]

  • 4. Synthesis of novel succinamide derivatives having the 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one skeleton as potent and selective M2 muscarinic receptor antagonists. I.
    Watanabe T, Kinoyama I, Kakefuda A, Okazaki T, Takizawa K, Hirano S, Shibata H, Yanagisawa I.
    Chem Pharm Bull (Tokyo); 1997 Jun 30; 45(6):996-1007. PubMed ID: 9214706
    [Abstract] [Full Text] [Related]

  • 5. Selective blockade of muscarinic M2 receptors in vivo by the new antagonist tripitramine.
    Angeli P, Cantalamessa F, Gulini U, Melchiorre C.
    Naunyn Schmiedebergs Arch Pharmacol; 1995 Sep 30; 352(3):304-7. PubMed ID: 8584046
    [Abstract] [Full Text] [Related]

  • 6. Methoctramine-related polymethylene tetraamines. 4. Chirality effect on M2 muscarinic receptor blocking activity.
    Giardinà D, Marrazzo A, Marucci G, Piloni MG, Quaglia W.
    Farmaco; 1991 Sep 30; 46(7-8):861-72. PubMed ID: 1793471
    [Abstract] [Full Text] [Related]

  • 7. Further investigation on methoctramine-related tetraamines: effects of terminal N-substitution and of chain length separating the four nitrogens on M2 muscarinic receptor blocking activity.
    Minarini A, Budriesi R, Chiarini A, Melchiorre C, Tumiatti V.
    Farmaco; 1991 Oct 30; 46(10):1167-78. PubMed ID: 1815579
    [Abstract] [Full Text] [Related]

  • 8. Structure-activity relationships among methoctramine-related polymethylene tetraamines. 3. Effect of the four nitrogens on M2 muscarinic blocking activity as revealed by symmetrical and unsymmetrical polyamines.
    Quaglia W, Giardinà D, Marucci G, Melchiorre C, Minarini A, Tumiatti V.
    Farmaco; 1991 Mar 30; 46(3):417-34. PubMed ID: 1892500
    [Abstract] [Full Text] [Related]

  • 9. Universal template approach to drug design: polyamines as selective muscarinic receptor antagonists.
    Bolognesi ML, Minarini A, Budriesi R, Cacciaguerra S, Chiarini A, Spampinato S, Tumiatti V, Melchiorre C.
    J Med Chem; 1998 Oct 08; 41(21):4150-60. PubMed ID: 9767650
    [Abstract] [Full Text] [Related]

  • 10. Prejunctional muscarinic receptors on cholinergic nerves in guinea pig airways are of the M2 subtype.
    Doelman CJ, Sprong RC, Nagtegaal JE, Rodrigues de Miranda JF, Bast A.
    Eur J Pharmacol; 1991 Jan 25; 193(1):117-9. PubMed ID: 2050188
    [Abstract] [Full Text] [Related]

  • 11. Design, synthesis, and biological evaluation of symmetrically and unsymmetrically substituted methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists.
    Rosini M, Budriesi R, Bixel MG, Bolognesi ML, Chiarini A, Hucho F, Krogsgaard-Larsen P, Mellor IR, Minarini A, Tumiatti V, Usherwood PN, Melchiorre C.
    J Med Chem; 1999 Dec 16; 42(25):5212-23. PubMed ID: 10602706
    [Abstract] [Full Text] [Related]

  • 12. In vitro characterization of tripitramine, a polymethylene tetraamine displaying high selectivity and affinity for muscarinic M2 receptors.
    Chiarini A, Budriesi R, Bolognesi ML, Minarini A, Melchiorre C.
    Br J Pharmacol; 1995 Apr 16; 114(7):1507-17. PubMed ID: 7606355
    [Abstract] [Full Text] [Related]

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  • 14. Synthesis of novel succinamide derivatives having a 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one skeleton as potent and selective M2 muscarinic receptor antagonists. II.
    Watanabe T, Kakefuda A, Kinoyama I, Takizawa K, Hirano S, Shibata H, Yanagisawa I.
    Chem Pharm Bull (Tokyo); 1997 Sep 16; 45(9):1458-69. PubMed ID: 9331998
    [Abstract] [Full Text] [Related]

  • 15. Methoctramine induces nonspecific airway hyperresponsiveness in vivo.
    Howell RE, Kovalsky MP, Laemont KD.
    Eur J Pharmacol; 1994 Nov 14; 265(1-2):67-75. PubMed ID: 7883031
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  • 17. Regional differences in the binding of selective muscarinic receptor antagonists in rat brain: comparison with minimum-energy conformations.
    Messer WS, Ellerbrock BR, Smith DA, Hoss W.
    J Med Chem; 1989 Jun 14; 32(6):1164-72. PubMed ID: 2724292
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  • 19. Inhibition of GTPase activity of Gi proteins and decreased agonist affinity at M2 muscarinic acetylcholine receptors by spermine and methoctramine.
    Daeffler L, Chahdi A, Gies JP, Landry Y.
    Br J Pharmacol; 1999 Jun 14; 127(4):1021-9. PubMed ID: 10433511
    [Abstract] [Full Text] [Related]

  • 20. Muscarinic receptor subtypes in guinea pig airways.
    Haddad EB, Landry Y, Gies JP.
    Am J Physiol; 1991 Oct 14; 261(4 Pt 1):L327-33. PubMed ID: 1928368
    [Abstract] [Full Text] [Related]

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