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131 related items for PubMed ID: 8251385

  • 1. Contrasting interspecies efficacy and toxicology of 1,2-diethyl-3-hydroxypyridin-4-one, CP94, relates to differing metabolism of the iron chelating site.
    Porter JB, Abeysinghe RD, Hoyes KP, Barra C, Huehns ER, Brooks PN, Blackwell MP, Araneta M, Brittenham G, Singh S.
    Br J Haematol; 1993 Sep; 85(1):159-68. PubMed ID: 8251385
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  • 2. Effect of iron overload on the metabolism and urinary recovery of 3-hydroxypyridin-4-one chelating agents in the rat.
    Choudhury R, Singh S.
    Drug Metab Dispos; 1995 Mar; 23(3):314-20. PubMed ID: 7628295
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  • 3. Characterization of two isomeric beta-d-glucosiduronic acids derived from 1,2-diethyl-3-hydroxypyridin-4-one (CP94) in rat liver homogenate incubates.
    Liu DY, Liu ZD, Piyamongkol S, Lu SL, Hider RC.
    J Pharm Pharmacol; 2002 Jul; 54(7):951-7. PubMed ID: 12162714
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  • 4. Inhibition of iron toxicity in rat and human hepatocyte cultures by the hydroxypyridin-4-ones CP20 and CP94.
    Chenoufi N, Hubert N, Loréal O, Morel I, Pasdeloup N, Cillard J, Brissot P, Lescoat G.
    J Hepatol; 1995 Aug; 23(2):166-73. PubMed ID: 7499788
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  • 5. Biliary and urinary metabolic profiles of 1,2-diethyl-3-hydroxypyridin-4-one (CP94) in the rat.
    Lu SL, Gosriwatana I, Liu DY, Liu ZD, Mallet AI, Hider RC.
    Drug Metab Dispos; 2000 Aug; 28(8):873-9. PubMed ID: 10901694
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  • 6. Lessons from preclinical and clinical studies with 1,2-diethyl-3-hydroxypyridin-4-one, CP94 and related compounds.
    Porter JB, Singh S, Hoyes KP, Epemolu O, Abeysinghe RD, Hider RC.
    Adv Exp Med Biol; 1994 Aug; 356():361-70. PubMed ID: 7887242
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  • 7. Urinary metabolic profiles in human and rat of 1,2-dimethyl- and 1,2-diethyl-substituted 3-hydroxypyridin-4-ones.
    Singh S, Epemolu RO, Dobbin PS, Tilbrook GS, Ellis BL, Damani LA, Hider RC.
    Drug Metab Dispos; 1992 Aug; 20(2):256-61. PubMed ID: 1352218
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  • 10. In vivo and in vitro effects of 3-hydroxypyridin-4-one chelators on murine hemopoiesis.
    Hoyes KP, Jones HM, Abeysinghe RD, Hider RC, Porter JB.
    Exp Hematol; 1993 Jan; 21(1):86-92. PubMed ID: 8417963
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  • 11. HPLC determination of 1,2-diethyl-3-hydroxypyridin-4-one (CP94), its iron complex [Fe(III) (CP94)3] and glucuronide conjugate [CP94-GLUC] in serum and urine of thalassaemic patients.
    Epemolu RO, Ackerman R, Porter JB, Hider RC, Damani LA, Singh S.
    J Pharm Biomed Anal; 1994 Jul; 12(7):923-30. PubMed ID: 7981322
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  • 12. Protoporphyria induced by the orally active iron chelator 1,2-diethyl-3-hydroxypyridin-4-one in C57BL/10ScSn mice.
    Smith AG, Clothier B, Francis JE, Gibbs AH, De Matteis F, Hider RC.
    Blood; 1997 Feb 01; 89(3):1045-51. PubMed ID: 9028337
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  • 14. Deferoxamine augments growth and pathogenicity of Rhizopus, while hydroxypyridinone chelators have no effect.
    Boelaert JR, Van Cutsem J, de Locht M, Schneider YJ, Crichton RR.
    Kidney Int; 1994 Mar 01; 45(3):667-71. PubMed ID: 8196268
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  • 16. Liver iron depletion and toxicity of the iron chelator deferiprone (L1, CP20) in the guinea pig.
    Wong A, Alder V, Robertson D, Papadimitriou J, Maserei J, Berdoukas V, Kontoghiorghes G, Taylor E, Baker E.
    Biometals; 1997 Oct 01; 10(4):247-56. PubMed ID: 9353871
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  • 17. Studies of in vivo iron mobilization by chelators in the ferrocene-loaded rat.
    Florence A, Ward RJ, Peters TJ, Crichton RR.
    Biochem Pharmacol; 1992 Sep 25; 44(6):1023-7. PubMed ID: 1417929
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