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310 related items for PubMed ID: 8255099

  • 1. Cross-resistance studies of folylpolyglutamate synthetase-deficient, methotrexate-resistant CCRF-CEM human leukemia sublines.
    McGuire JJ, Heitzman KJ, Haile WH, Russell CA, McCloskey DE, Piper JR.
    Leukemia; 1993 Dec; 7(12):1996-2003. PubMed ID: 8255099
    [Abstract] [Full Text] [Related]

  • 2. Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines.
    Liani E, Rothem L, Bunni MA, Smith CA, Jansen G, Assaraf YG.
    Int J Cancer; 2003 Feb 20; 103(5):587-99. PubMed ID: 12494465
    [Abstract] [Full Text] [Related]

  • 3. Decreased folylpolyglutamate synthetase activity as a mechanism of methotrexate resistance in CCRF-CEM human leukemia sublines.
    McCloskey DE, McGuire JJ, Russell CA, Rowan BG, Bertino JR, Pizzorno G, Mini E.
    J Biol Chem; 1991 Apr 05; 266(10):6181-7. PubMed ID: 2007575
    [Abstract] [Full Text] [Related]

  • 4. Impact of polyglutamation on sensitivity to raltitrexed and methotrexate in relation to drug-induced inhibition of de novo thymidylate and purine biosynthesis in CCRF-CEM cell lines.
    Barnes MJ, Estlin EJ, Taylor GA, Aherne GW, Hardcastle A, McGuire JJ, Calvete JA, Lunec J, Pearson AD, Newell DR.
    Clin Cancer Res; 1999 Sep 05; 5(9):2548-58. PubMed ID: 10499632
    [Abstract] [Full Text] [Related]

  • 5. Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.
    Mauritz R, Peters GJ, Priest DG, Assaraf YG, Drori S, Kathmann I, Noordhuis P, Bunni MA, Rosowsky A, Schornagel JH, Pinedo HM, Jansen G.
    Biochem Pharmacol; 2002 Jan 15; 63(2):105-15. PubMed ID: 11841783
    [Abstract] [Full Text] [Related]

  • 6. Folylpolyglutamate synthetase expression in antifolate-sensitive and -resistant human cell lines.
    McGuire JJ, Russell CA.
    Oncol Res; 1998 Jan 15; 10(4):193-200. PubMed ID: 9778690
    [Abstract] [Full Text] [Related]

  • 7. Effect of bridge region variation on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines.
    Gangjee A, Devraj R, McGuire JJ, Kisliuk RL.
    J Med Chem; 1995 Sep 15; 38(19):3798-805. PubMed ID: 7562910
    [Abstract] [Full Text] [Related]

  • 8. Thymidylate synthase as a target for growth inhibition in methotrexate-sensitive and -resistant human head and neck cancer and leukemia cell lines.
    McGuire JJ, Magee KJ, Russell CA, Canestrari JM.
    Oncol Res; 1997 Sep 15; 9(3):139-47. PubMed ID: 9220499
    [Abstract] [Full Text] [Related]

  • 9. The influence of drug-exposure conditions on the development of resistance to methotrexate or ZD1694 in cultured human leukaemia cells.
    Takemura Y, Kobayashi H, Gibson W, Kimbell R, Miyachi H, Jackman AL.
    Int J Cancer; 1996 Mar 28; 66(1):29-36. PubMed ID: 8608962
    [Abstract] [Full Text] [Related]

  • 10. Cytotoxicity of trimetrexate against antifolate-resistant human T-cell leukemia cell lines developed in oxidized or reduced folate.
    Miyachi H, Takemura Y, Kobayashi H, Ando Y.
    Jpn J Cancer Res; 1997 Sep 28; 88(9):900-6. PubMed ID: 9369939
    [Abstract] [Full Text] [Related]

  • 11. Biochemical and growth inhibition studies of methotrexate and aminopterin analogues containing a tetrazole ring in place of the gamma-carboxyl group.
    McGuire JJ, Russell CA, Bolanowska WE, Freitag CM, Jones CS, Kalman TI.
    Cancer Res; 1990 Mar 15; 50(6):1726-31. PubMed ID: 2306727
    [Abstract] [Full Text] [Related]

  • 12. Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.
    Diddens H, Niethammer D, Jackson RC.
    Cancer Res; 1983 Nov 15; 43(11):5286-92. PubMed ID: 6225514
    [Abstract] [Full Text] [Related]

  • 13. Multifactorial resistance to 5,10-dideazatetrahydrofolic acid in cell lines derived from human lymphoblastic leukemia CCRF-CEM.
    Pizzorno G, Moroson BA, Cashmore AR, Russello O, Mayer JR, Galivan J, Bunni MA, Priest DG, Beardsley GP.
    Cancer Res; 1995 Feb 01; 55(3):566-73. PubMed ID: 7834626
    [Abstract] [Full Text] [Related]

  • 14. Studies on the cross resistance of folylpolyglutamate synthetase-deficient, methotrexate-resistant CCRF-CEM human leukemia sublines.
    McGuire JJ, Heitzman KJ, Haile WH, Russell CA, McCloskey DE, Piper JR.
    Adv Exp Med Biol; 1993 Feb 01; 338():667-70. PubMed ID: 8304203
    [No Abstract] [Full Text] [Related]

  • 15. Regulation of carrier-mediated transport of folates and antifolates in methotrexate-sensitive and-resistant leukemia cells.
    Jansen G, Mauritz RM, Assaraf YG, Sprecher H, Drori S, Kathmann I, Westerhof GR, Priest DG, Bunni M, Pinedo HM, Schornagel JH, Peters GJ.
    Adv Enzyme Regul; 1997 Feb 01; 37():59-76. PubMed ID: 9381986
    [Abstract] [Full Text] [Related]

  • 16. Determinants of the disparate antitumor activities of (6R)-5,10-dideaza-5,6,7,8-tetrahydrofolate and methotrexate toward human lymphoblastic leukemia cells, characterized by severely impaired antifolate membrane transport.
    Matherly LH, Angeles SM, McGuire JJ.
    Biochem Pharmacol; 1993 Dec 14; 46(12):2185-95. PubMed ID: 7506026
    [Abstract] [Full Text] [Related]

  • 17. Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia.
    Stark M, Wichman C, Avivi I, Assaraf YG.
    Blood; 2009 Apr 30; 113(18):4362-9. PubMed ID: 19131550
    [Abstract] [Full Text] [Related]

  • 18. Large diversity in transport-mediated methotrexate resistance in human leukemia cell line CCRF-CEM established in a high concentration of leucovorin.
    Asai S, Miyachi H, Kobayashi H, Takemura Y, Ando Y.
    Cancer Sci; 2003 Feb 30; 94(2):210-4. PubMed ID: 12708499
    [Abstract] [Full Text] [Related]

  • 19. Evaluation of methotrexate sensitivity in human leukemia cell lines by an adenosine triphosphate bioluminescence assay.
    Pinzani P, Carotti S, Gerli A, Pazzagli M, Mazzei T, Mini E.
    Anticancer Drugs; 1997 Sep 30; 8(8):767-77. PubMed ID: 9396621
    [Abstract] [Full Text] [Related]

  • 20. N10-propargyl-5,8-dideazafolic acid (CB3717): inhibitory effects on human leukemia cell lines resistant to methotrexate or trimetrexate.
    Takemura Y, Ohnuma T.
    Mt Sinai J Med; 1992 Oct 30; 59(5):419-24. PubMed ID: 1435841
    [Abstract] [Full Text] [Related]

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