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Journal Abstract Search

133 related items for PubMed ID: 8292591

  • 1. The role of lysine 166 in the mechanism of mandelate racemase from Pseudomonas putida: mechanistic and crystallographic evidence for stereospecific alkylation by (R)-alpha-phenylglycidate.
    Landro JA, Gerlt JA, Kozarich JW, Koo CW, Shah VJ, Kenyon GL, Neidhart DJ, Fujita S, Petsko GA.
    Biochemistry; 1994 Jan 25; 33(3):635-43. PubMed ID: 8292591
    [Abstract] [Full Text] [Related]

  • 2. Mechanism of the reaction catalyzed by mandelate racemase: structure and mechanistic properties of the D270N mutant.
    Schafer SL, Barrett WC, Kallarakal AT, Mitra B, Kozarich JW, Gerlt JA, Clifton JG, Petsko GA, Kenyon GL.
    Biochemistry; 1996 May 07; 35(18):5662-9. PubMed ID: 8639525
    [Abstract] [Full Text] [Related]

  • 3. Mechanism of the reaction catalyzed by mandelate racemase: structure and mechanistic properties of the K166R mutant.
    Kallarakal AT, Mitra B, Kozarich JW, Gerlt JA, Clifton JG, Petsko GA, Kenyon GL.
    Biochemistry; 1995 Mar 07; 34(9):2788-97. PubMed ID: 7893690
    [Abstract] [Full Text] [Related]

  • 4. Mechanism of the reaction catalyzed by mandelate racemase: importance of electrophilic catalysis by glutamic acid 317.
    Mitra B, Kallarakal AT, Kozarich JW, Gerlt JA, Clifton JG, Petsko GA, Kenyon GL.
    Biochemistry; 1995 Mar 07; 34(9):2777-87. PubMed ID: 7893689
    [Abstract] [Full Text] [Related]

  • 5. Potent inhibition of mandelate racemase by a fluorinated substrate-product analogue with a novel binding mode.
    Nagar M, Lietzan AD, St Maurice M, Bearne SL.
    Biochemistry; 2014 Feb 25; 53(7):1169-78. PubMed ID: 24472022
    [Abstract] [Full Text] [Related]

  • 6. Selection and characterization of a mutant of the cloned gene for mandelate racemase that confers resistance to an affinity label by greatly enhanced production of enzyme.
    Tsou AY, Ransom SC, Gerlt JA, Powers VM, Kenyon GL.
    Biochemistry; 1989 Feb 07; 28(3):969-75. PubMed ID: 2496759
    [Abstract] [Full Text] [Related]

  • 7. Perturbing the hydrophobic pocket of mandelate racemase to probe phenyl motion during catalysis.
    Siddiqi F, Bourque JR, Jiang H, Gardner M, St Maurice M, Blouin C, Bearne SL.
    Biochemistry; 2005 Jun 28; 44(25):9013-21. PubMed ID: 15966725
    [Abstract] [Full Text] [Related]

  • 8. An additional role for the Brønsted acid-base catalysts of mandelate racemase in transition state stabilization.
    Nagar M, Bearne SL.
    Biochemistry; 2015 Nov 10; 54(44):6743-52. PubMed ID: 26480244
    [Abstract] [Full Text] [Related]

  • 9. Reaction intermediate analogues for mandelate racemase: interaction between Asn 197 and the alpha-hydroxyl of the substrate promotes catalysis.
    St Maurice M, Bearne SL.
    Biochemistry; 2000 Nov 07; 39(44):13324-35. PubMed ID: 11063568
    [Abstract] [Full Text] [Related]

  • 10. A Paradigm for CH Bond Cleavage: Structural and Functional Aspects of Transition State Stabilization by Mandelate Racemase.
    Bearne SL, St Maurice M.
    Adv Protein Chem Struct Biol; 2017 Nov 07; 109():113-160. PubMed ID: 28683916
    [Abstract] [Full Text] [Related]

  • 11. Structure of mandelate racemase with bound intermediate analogues benzohydroxamate and cupferron.
    Lietzan AD, Nagar M, Pellmann EA, Bourque JR, Bearne SL, St Maurice M.
    Biochemistry; 2012 Feb 14; 51(6):1160-70. PubMed ID: 22264153
    [Abstract] [Full Text] [Related]

  • 12. Hydrophobic nature of the active site of mandelate racemase.
    St Maurice M, Bearne SL.
    Biochemistry; 2004 Mar 09; 43(9):2524-32. PubMed ID: 14992589
    [Abstract] [Full Text] [Related]

  • 13. Intermediate analogue inhibitors of mandelate racemase: N-Hydroxyformanilide and cupferron.
    Bourque JR, Burley RK, Bearne SL.
    Bioorg Med Chem Lett; 2007 Jan 01; 17(1):105-8. PubMed ID: 17055725
    [Abstract] [Full Text] [Related]

  • 14. Mechanism of the reaction catalyzed by mandelate racemase. 2. Crystal structure of mandelate racemase at 2.5-A resolution: identification of the active site and possible catalytic residues.
    Neidhart DJ, Howell PL, Petsko GA, Powers VM, Li RS, Kenyon GL, Gerlt JA.
    Biochemistry; 1991 Sep 24; 30(38):9264-73. PubMed ID: 1892834
    [Abstract] [Full Text] [Related]

  • 15. Redefining the minimal substrate tolerance of mandelate racemase. Racemization of trifluorolactate.
    Nagar M, Narmandakh A, Khalak Y, Bearne SL.
    Biochemistry; 2011 Oct 18; 50(41):8846-52. PubMed ID: 21894901
    [Abstract] [Full Text] [Related]

  • 16. Altering the Y137-K164-K166 triad of mandelate racemase and its effect on the observed pKa of the Brønsted base catalysts.
    Fetter CM, Morrison ZA, Nagar M, Douglas CD, Bearne SL.
    Arch Biochem Biophys; 2019 May 15; 666():116-126. PubMed ID: 30935886
    [Abstract] [Full Text] [Related]

  • 17. Inhibition of mandelate racemase by alpha-fluorobenzylphosphonates.
    St Maurice M, Bearne SL, Lu W, Taylor SD.
    Bioorg Med Chem Lett; 2003 Jun 16; 13(12):2041-4. PubMed ID: 12781191
    [Abstract] [Full Text] [Related]

  • 18. Mutational analysis of the active site flap (20s loop) of mandelate racemase.
    Bourque JR, Bearne SL.
    Biochemistry; 2008 Jan 15; 47(2):566-78. PubMed ID: 18092808
    [Abstract] [Full Text] [Related]

  • 19. The role of residue S139 of mandelate racemase: synergistic effect of S139 and E317 on transition state stabilization.
    Gu J, Yu H.
    J Biomol Struct Dyn; 2012 Jan 15; 30(5):585-93. PubMed ID: 22731931
    [Abstract] [Full Text] [Related]

  • 20. Mechanism of the reaction catalyzed by mandelate racemase. 3. Asymmetry in reactions catalyzed by the H297N mutant.
    Landro JA, Kallarakal AT, Ransom SC, Gerlt JA, Kozarich JW, Neidhart DJ, Kenyon GL.
    Biochemistry; 1991 Sep 24; 30(38):9274-81. PubMed ID: 1909893
    [Abstract] [Full Text] [Related]

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