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130 related items for PubMed ID: 8313376

  • 1. The potent carcinogen dibenzo[a,l]pyrene is metabolically activated to fjord-region 11,12-diol 13,14-epoxides in human mammary carcinoma MCF-7 cell cultures.
    Ralston SL, Lau HH, Seidel A, Luch A, Platt KL, Baird WM.
    Cancer Res; 1994 Feb 15; 54(4):887-90. PubMed ID: 8313376
    [Abstract] [Full Text] [Related]

  • 2. Metabolic activation of racemic and enantiomeric trans-8, 9-dihydroxy-8,9-dihydrodibenzo[a,l]pyrene (dibenzo[def,p]chrysene) to dibenzo[a,l]pyrene-bis-dihydrodiols by induced rat liver microsomes and a recombinant human P450 1A1 system: the role of the K-region-derived metabolic intermediates in the formation of dibenzo[a,l]pyrene-DNA adducts.
    Nesnow S, Davis C, Padgett W, George M, Lambert G, Meyers F, Allison J, Adams L, King LC.
    Chem Res Toxicol; 1998 Dec 15; 11(12):1596-607. PubMed ID: 9860506
    [Abstract] [Full Text] [Related]

  • 3. Stereoselective activation of dibenzo[a,l]pyrene to (-)-anti (11R,12S,13S,14R)- and (+)-syn(11S,12R,13S,14R)-11,12-diol-13,14-epoxides which bind extensively to deoxyadenosine residues of DNA in the human mammary carcinoma cell line MCF-7.
    Ralston SL, Seidel A, Luch A, Platt KL, Baird WM.
    Carcinogenesis; 1995 Dec 15; 16(12):2899-907. PubMed ID: 8603462
    [Abstract] [Full Text] [Related]

  • 4. The K-region trans-8,9-diol does not significantly contribute as an intermediate in the metabolic activation of dibenzo[a,l]pyrene to DNA-binding metabolites by human cytochrome P450 1A1 or 1B1.
    Luch A, Kishiyama S, Seidel A, Doehmer J, Greim H, Baird WM.
    Cancer Res; 1999 Sep 15; 59(18):4603-9. PubMed ID: 10493514
    [Abstract] [Full Text] [Related]

  • 5. Stereoselective activation of dibenzo[a,l]pyrene and its trans-11,12-dihydrodiol to fjord region 11,12-diol 13,14-epoxides in a human mammary carcinoma MCF-7 cell-mediated V79 cell mutation assay.
    Ralston SL, Coffing SL, Seidel A, Luch A, Platt KL, Baird WM.
    Chem Res Toxicol; 1997 Jun 15; 10(6):687-93. PubMed ID: 9208176
    [Abstract] [Full Text] [Related]

  • 6. A quantitative comparison of dibenzo[a,l]pyrene-DNA adduct formation by recombinant human cytochrome P450 microsomes.
    King LC, Adams L, Allison J, Kohan MJ, Nelson G, Desai D, Amin S, Ross JA.
    Mol Carcinog; 1999 Oct 15; 26(2):74-82. PubMed ID: 10506751
    [Abstract] [Full Text] [Related]

  • 7. Formation of stable adducts and absence of depurinating DNA adducts in cells and DNA treated with the potent carcinogen dibenzo[a,l]pyrene or its diol epoxides.
    Melendez-Colon VJ, Smith CA, Seidel A, Luch A, Platt KL, Baird WM.
    Proc Natl Acad Sci U S A; 1997 Dec 09; 94(25):13542-7. PubMed ID: 9391062
    [Abstract] [Full Text] [Related]

  • 8. Formation of stable DNA adducts and apurinic sites upon metabolic activation of bay and fjord region polycyclic aromatic hydrocarbons in human cell cultures.
    Melendez-Colon VJ, Luch A, Seidel A, Baird WM.
    Chem Res Toxicol; 2000 Jan 09; 13(1):10-7. PubMed ID: 10649961
    [Abstract] [Full Text] [Related]

  • 9. A novel method for the isolation and identification of stable DNA adducts formed by Dibenzo[a,l]pyrene and Dibenzo[a,l]pyrene 11, 12-dihydrodiol 13,14-epoxides in vitro.
    Devanesan P, Ariese F, Jankowiak R, Small GJ, Rogan EG, Cavalieri EL.
    Chem Res Toxicol; 1999 Sep 09; 12(9):796-801. PubMed ID: 10490500
    [Abstract] [Full Text] [Related]

  • 10. Comparison of the morphological transforming activities of dibenzo[a,l]pyrene and benzo[a]pyrene in C3H10T1/2CL8 cells and characterization of the dibenzo[a,l]pyrene-DNA adducts.
    Nesnow S, Davis C, Nelson G, Ross JA, Allison J, Adams L, King LC.
    Carcinogenesis; 1997 Oct 09; 18(10):1973-8. PubMed ID: 9364008
    [Abstract] [Full Text] [Related]

  • 11. DNA damage, repair, and mutation induction by (+)-Syn and (-)-anti-dibenzo[a,l]pyrene-11,12-diol-13,14-epoxides in mouse cells.
    Yoon JH, Besaratinia A, Feng Z, Tang MS, Amin S, Luch A, Pfeifer GP.
    Cancer Res; 2004 Oct 15; 64(20):7321-8. PubMed ID: 15492252
    [Abstract] [Full Text] [Related]

  • 12. The level of DNA modification by (+)-syn-(11S,12R,13S,14R)- and (-)-anti-(11R,12S,13S,14R)-dihydrodiol epoxides of dibenzo[a,l]pyrene determined the effect on the proteins p53 and p21WAF1 in the human mammary carcinoma cell line MCF-7.
    Luch A, Kudla K, Seidel A, Doehmer J, Greim H, Baird WM.
    Carcinogenesis; 1999 May 15; 20(5):859-65. PubMed ID: 10334204
    [Abstract] [Full Text] [Related]

  • 13. Spectral and conformational analysis of deoxyadenosine adducts derived from syn- and anti-Dibenzo[a,l]pyrene diol epoxides: fluorescence studies.
    Jankowiak R, Lin CH, Zamzow D, Roberts KP, Li KM, Small GJ.
    Chem Res Toxicol; 1999 Sep 15; 12(9):768-77. PubMed ID: 10490497
    [Abstract] [Full Text] [Related]

  • 14. Comparison of cytochrome P450- and peroxidase-dependent metabolic activation of the potent carcinogen dibenzo[a,l]pyrene in human cell lines: formation of stable DNA adducts and absence of a detectable increase in apurinic sites.
    Melendez-Colon VJ, Luch A, Seidel A, Baird WM.
    Cancer Res; 1999 Apr 01; 59(7):1412-6. PubMed ID: 10197604
    [Abstract] [Full Text] [Related]

  • 15. Stable expression of human cytochrome P450 1B1 in V79 Chinese hamster cells and metabolically catalyzed DNA adduct formation of dibenzo[a,l]pyrene.
    Luch A, Coffing SL, Tang YM, Schneider A, Soballa V, Greim H, Jefcoate CR, Seidel A, Greenlee WF, Baird WM, Doehmer J.
    Chem Res Toxicol; 1998 Jun 01; 11(6):686-95. PubMed ID: 9625737
    [Abstract] [Full Text] [Related]

  • 16. Synthesis and characterization of site-specific and stereoisomeric fjord dibenzo[a,l]pyrene diol epoxide-N(6)-adenine adducts: unusual thermal stabilization of modified DNA duplexes.
    Ruan Q, Kolbanovskiy A, Zhuang P, Chen J, Krzeminski J, Amin S, Geacintov NE.
    Chem Res Toxicol; 2002 Feb 01; 15(2):249-61. PubMed ID: 11849052
    [Abstract] [Full Text] [Related]

  • 17. Metabolic activation of dibenzo[a,l]pyrene by human cytochrome P450 1A1 and P450 1B1 expressed in V79 Chinese hamster cells.
    Luch A, Schober W, Soballa VJ, Raab G, Greim H, Jacob J, Doehmer J, Seidel A.
    Chem Res Toxicol; 1999 Apr 01; 12(4):353-64. PubMed ID: 10207125
    [Abstract] [Full Text] [Related]

  • 18. Cytochrome P450 1B1 determines susceptibility to dibenzo[a,l]pyrene-induced tumor formation.
    Buters JT, Mahadevan B, Quintanilla-Martinez L, Gonzalez FJ, Greim H, Baird WM, Luch A.
    Chem Res Toxicol; 2002 Sep 01; 15(9):1127-35. PubMed ID: 12230405
    [Abstract] [Full Text] [Related]

  • 19. Preparation, isolation, and characterization of Dibenzo[a,l]pyrene diol epoxide-deoxyribonucleoside monophosphate adducts by HPLC and fluorescence line-narrowing spectroscopy.
    Devanesan P, Ariese F, Jankowiak R, Small GJ, Rogan EG, Cavalieri EL.
    Chem Res Toxicol; 1999 Sep 01; 12(9):789-95. PubMed ID: 10490499
    [Abstract] [Full Text] [Related]

  • 20. Conformational studies of stereoisomeric tetrols derived from syn- and anti-dibenzo[a,l]pyrene diol epoxides.
    Jankowiak R, Ariese F, Zamzow D, Luch A, Kroth H, Seidel A, Small GJ.
    Chem Res Toxicol; 1997 Jun 01; 10(6):677-86. PubMed ID: 9208175
    [Abstract] [Full Text] [Related]

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