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171 related items for PubMed ID: 8394082

  • 1. A cytochrome P450 isozyme having aldehyde oxygenase activity plays a major role in metabolizing cannabinoids by mouse hepatic microsomes.
    Watanabe K, Narimatsu S, Matsunaga T, Yamamoto I, Yoshimura H.
    Biochem Pharmacol; 1993 Aug 03; 46(3):405-11. PubMed ID: 8394082
    [Abstract] [Full Text] [Related]

  • 2. Catalytic activity of cytochrome P450 isozymes purified from rat liver in converting 11-oxo-delta 8-tetrahydrocannabinol to delta 8-tetrahydrocannabinol-11-oic acid.
    Watanabe K, Matsunaga T, Narimatsu S, Yamamoto I, Imaoka S, Funae Y, Yoshimura H.
    Biochem Pharmacol; 1991 Aug 22; 42(6):1255-9. PubMed ID: 1653566
    [Abstract] [Full Text] [Related]

  • 3. Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes.
    Watanabe K, Yamaori S, Funahashi T, Kimura T, Yamamoto I.
    Life Sci; 2007 Mar 20; 80(15):1415-9. PubMed ID: 17303175
    [Abstract] [Full Text] [Related]

  • 4. Immunochemical characterization of a cytochrome P450 isozyme and a protein purified from liver microsomes of male guinea pigs and their roles in the oxidative metabolism of delta 9-tetrahydrocannabinol by guinea pig liver microsomes.
    Narimatsu S, Akutsu Y, Matsunaga T, Watanabe K, Yamamoto I, Yoshimura H.
    Biochem Pharmacol; 1992 Apr 15; 43(8):1729-36. PubMed ID: 1315542
    [Abstract] [Full Text] [Related]

  • 5. Recent advances in the metabolism of cannabinoids.
    Yamamoto I, Watanabe K, Narimatsu S, Yoshimura H.
    Int J Biochem Cell Biol; 1995 Aug 15; 27(8):741-6. PubMed ID: 7584607
    [Abstract] [Full Text] [Related]

  • 6. Involvement of CYP2C in the metabolism of cannabinoids by human hepatic microsomes from an old woman.
    Watanabe K, Matsunaga T, Yamamoto I, Funae Y, Yoshimura H.
    Biol Pharm Bull; 1995 Aug 15; 18(8):1138-41. PubMed ID: 8535411
    [Abstract] [Full Text] [Related]

  • 7. In vitro and in vivo interactions of delta 8-tetra-hydrocannabinol and its metabolites with hepatic microsomal drug metabolizing enzyme systems of mice.
    Watanabe K, Yamamoto I, Oguri K, Yoshimura H.
    J Pharmacobiodyn; 1981 Aug 15; 4(8):604-11. PubMed ID: 6271944
    [Abstract] [Full Text] [Related]

  • 8. Microsomal alcohol oxygenase: purification and characterization of a cytochrome P450 responsible for oxidation of 7-hydroxy-delta 8-tetrahydrocannabinol to 7-oxo-delta 8-tetrahydrocannabinol in guinea pig liver.
    Matsunaga T, Tanaka H, Komura A, Watanabe K, Yamamoto I, Yoshimura H.
    Arch Biochem Biophys; 1997 Dec 01; 348(1):56-64. PubMed ID: 9390174
    [Abstract] [Full Text] [Related]

  • 9. Characterization of microsomal alcohol oxygenase catalyzing the oxidation of 7-hydroxy-delta 8-tetrahydrocannabinol to 7-oxo-delta 8-tetrahydrocannabinol in rat liver.
    Matsunaga T, Shibayama K, Higuchi S, Tanaka H, Watanabe K, Yamamoto I.
    Biol Pharm Bull; 2000 Jan 01; 23(1):43-6. PubMed ID: 10706409
    [Abstract] [Full Text] [Related]

  • 10. Monkey hepatic microsomal alcohol oxygenase: purification and characterization of a cytochrome P450 enzyme catalyzing the stereoselective oxidation of 7alpha- and 7beta-hydroxy-delta8-tetrahydrocannabinol to 7-oxo-delta8-tetrahydrocannabinol.
    Matsunaga T, Iwawaki Y, Komura A, Watanabe K, Kageyama T, Yamamoto I.
    Biol Pharm Bull; 2002 Jan 01; 25(1):42-7. PubMed ID: 11824554
    [Abstract] [Full Text] [Related]

  • 11. Cannabinoid Metabolites as Inhibitors of Major Hepatic CYP450 Enzymes, with Implications for Cannabis-Drug Interactions.
    Nasrin S, Watson CJW, Perez-Paramo YX, Lazarus P.
    Drug Metab Dispos; 2021 Dec 01; 49(12):1070-1080. PubMed ID: 34493602
    [Abstract] [Full Text] [Related]

  • 12. CYP3A4 is a major isoform responsible for oxidation of 7-hydroxy-Delta(8)-tetrahydrocannabinol to 7-oxo-delta(8)-tetrahydrocannabinol in human liver microsomes.
    Matsunaga T, Kishi N, Higuchi S, Watanabe K, Ohshima T, Yamamoto I.
    Drug Metab Dispos; 2000 Nov 01; 28(11):1291-6. PubMed ID: 11038155
    [Abstract] [Full Text] [Related]

  • 13. [MALDO (microsomal aldehyde oxygenase): a cytochrome P-450 isozyme purified from mouse hepatic microsomes that catalyzes the oxygenation of aldehyde to carboxylic acid].
    Yamamoto I, Watanabe K.
    Seikagaku; 1991 Jul 01; 63(7):504-7. PubMed ID: 1655922
    [No Abstract] [Full Text] [Related]

  • 14. Metabolism of delta 9-tetrahydrocannabinol by cytochrome P450 isozymes purified from hepatic microsomes of monkeys.
    Matsunaga T, Iwawaki Y, Watanabe K, Yamamoto I, Kageyama T, Yoshimura H.
    Life Sci; 1995 Jul 01; 56(23-24):2089-95. PubMed ID: 7776836
    [Abstract] [Full Text] [Related]

  • 15. Mouse hepatic microsomal enzyme that catalyzes oxidation of 11-oxo-delta 8-tetrahydrocannabinol to delta 8-tetrahydrocannabinol-11-oic acid.
    Watanabe K, Hirahashi N, Narimatsu S, Yamamoto I, Yoshimura H.
    Drug Metab Dispos; 1991 Jul 01; 19(1):218-21. PubMed ID: 1673402
    [Abstract] [Full Text] [Related]

  • 16. Effect of repeated administration of 11-hydroxy-delta 8-tetrahydrocannabinol, an active metabolite of delta 8-tetrahydrocannabinol, on the hepatic microsomal drug-metabolizing enzyme system of mice.
    Watanabe K, Arai M, Narimatsu S, Yamamoto I, Yoshimura H.
    Biochem Pharmacol; 1986 Jun 01; 35(11):1861-5. PubMed ID: 3013200
    [Abstract] [Full Text] [Related]

  • 17. Mechanism of hepatic microsomal oxidation of 11-hydroxy-delta 8-tetrahydrocannabinol to 11-oxo-delta 8-tetrahydrocannabinol. Evidence for hydration of the aldehyde formed.
    Watanabe K, Matsunaga T, Narimatsu S, Yamamoto I, Yoshimura H.
    J Pharmacobiodyn; 1992 Jun 01; 15(6):311-7. PubMed ID: 1331394
    [Abstract] [Full Text] [Related]

  • 18. Characterization of human hepatic and extrahepatic UDP-glucuronosyltransferase enzymes involved in the metabolism of classic cannabinoids.
    Mazur A, Lichti CF, Prather PL, Zielinska AK, Bratton SM, Gallus-Zawada A, Finel M, Miller GP, Radomińska-Pandya A, Moran JH.
    Drug Metab Dispos; 2009 Jul 01; 37(7):1496-504. PubMed ID: 19339377
    [Abstract] [Full Text] [Related]

  • 19. Oxidation mechanism of 7-hydroxy-delta 8-tetrahydrocannabinol and 8-hydroxy-delta 9-tetrahydrocannabinol to the corresponding ketones by CYP3A11.
    Matsunaga T, Tanaka H, Higuchi S, Shibayama K, Kishi N, Watanabe K, Yamamoto I.
    Drug Metab Dispos; 2001 Nov 01; 29(11):1485-91. PubMed ID: 11602526
    [Abstract] [Full Text] [Related]

  • 20. Major cytochrome P450 enzymes responsible for microsomal aldehyde oxygenation of 11-oxo-Delta8-tetrahydrocannabinol and 9-anthraldehyde in human liver.
    Watanabe K, Matsunaga T, Kimura T, Funahashi T, Funae Y, Ohshima T, Yamamoto I.
    Drug Metab Pharmacokinet; 2002 Nov 01; 17(6):516-21. PubMed ID: 15618706
    [Abstract] [Full Text] [Related]

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